DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5543 and AgaP_AGAP012029

DIOPT Version :9

Sequence 1:	NP_611832.1	Gene:	CG5543 / 37768	FlyBaseID:	FBgn0034908	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_320491.4	Gene:	AgaP_AGAP012029 / 1280633	VectorBaseID:	AGAP012029	Length:	378	Species:	Anopheles gambiae

Alignment Length:	424	Identity:	90/424 - (21%)
Similarity:	157/424 - (37%)	Gaps:	119/424 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   280 KGHVAQLTSGCWHPFNREQFLTAALDGTLRIWQGLKSKEQLQVIKTRAQGGLRTNAASCNFNRDA 344
            |||..:||...::| ...:|:|::.|.:..:|   .:.||::.::..|...:..:..   ::.|.
Mosquito    11 KGHRGKLTGLSFNP-EGTRFVTSSTDHSAIVW---TNNEQVRCMRFEAHTDVVNDVC---WSPDG 68

  Fly   345 TLIAAGCVDGSIQTWDTRKMFVNTTHCVRDAHQKGSEITSIVFSYMGQQLATRSNDETMKLWDLR 409
            .:|:....|.|::.| ...|..|:.    :.....|.:.|:.|...|::|.|.|:|:|:|||.:.
Mosquito    69 RIISTVSKDRSVKIW-VPSMLGNSD----EFRGHTSNVRSVDFDPTGKKLLTASDDKTVKLWKVS 128

  Fly   410 QFKQPLHTWTNLFSRYDTTDCC-FSP---------DDRLL-----VTGESLPKGQAEANLYFYST 459
            : ||.|.::|   ...:...|. |||         |||.|     .||:.:..        ||..
Mosquito   129 R-KQFLSSFT---GHTNWVRCARFSPNGKLIASCGDDRTLKLFDPATGQCVHS--------FYDQ 181

  Fly   460 KSYEEVQRIPVSNAHVVKTLWHPKLNQLFVSCGNGTIKC----------YY----------DEHR 504
            |...            .|..|||....:.::..|..:|.          ||          |.|.
Mosquito   182 KGAG------------CKVAWHPDSTLVAIALDNCRVKIFDINIRKLIQYYRIYDGPVNSLDFHP 234

  Fly   505 S----IRGAKLCVVKTHRKRQPMEMVGVSQI--ITPHALPLFRQEKSRTSR----------KRME 553
            |    |.|:...|.|.      ::::...||  :|.|..|:...:.|:..:          ..:.
Mosquito   235 SGNYLITGSDDGVTKI------IDLLEGRQIFTLTGHRGPVTTVKFSKDGQLFATGSDDCHVMLW 293

  Fly   554 KARMDPVKSQRPDLPITSGQGGRVASSGGTLSSYVIRNLGLSKRVDDDQDPREAILKYAKDAAEN 618
            ||.:|...:|.   .:.:.:|....|:....|.        .:::..::|..||   :|.|..|:
Mosquito   294 KANLDNDSAQN---SLYTPEGSSCESTHPAASD--------QRKLSFNRDVSEA---HADDDDES 344

  Fly   619 PYWIAPAYKQTQPKAIFSEKLPADEPATKKPKTE 652
            .|            :...|.||.........|||
Mosquito   345 AY------------SCNKENLPDTSIFVDATKTE 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5543	NP_611832.1	WD40	<172..519	CDD:225201	64/277 (23%)
		WD40	180..497	CDD:295369	54/231 (23%)
		WD40 repeat	185..227	CDD:293791
		WD40 repeat	233..268	CDD:293791
		WD40 repeat	273..329	CDD:293791	13/48 (27%)
		WD40 repeat	337..374	CDD:293791	7/36 (19%)
		WD40 repeat	382..419	CDD:293791	14/36 (39%)
		WD40 repeat	427..469	CDD:293791	13/56 (23%)
		WD40 repeat	475..497	CDD:293791	5/21 (24%)
AgaP_AGAP012029	XP_320491.4	WD40	8..294	CDD:238121	70/324 (22%)
		WD40	10..312	CDD:225201	74/345 (21%)
		WD40 repeat	17..54	CDD:293791	9/40 (23%)
		WD40 repeat	60..96	CDD:293791	7/43 (16%)
		WD40 repeat	101..137	CDD:293791	14/36 (39%)
		WD40 repeat	144..179	CDD:293791	10/42 (24%)
		WD40 repeat	186..219	CDD:293791	6/32 (19%)
		WD40 repeat	227..263	CDD:293791	9/41 (22%)
		WD40 repeat	269..293	CDD:293791	1/23 (4%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910