DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5543 and AgaP_AGAP006042

DIOPT Version :9

Sequence 1:	NP_611832.1	Gene:	CG5543 / 37768	FlyBaseID:	FBgn0034908	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_316089.4	Gene:	AgaP_AGAP006042 / 1276713	VectorBaseID:	AGAP006042	Length:	1030	Species:	Anopheles gambiae

Alignment Length:	640	Identity:	113/640 - (17%)
Similarity:	188/640 - (29%)	Gaps:	234/640 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 NVNVPPAEPRSNETEAEDAKEST-EASGNGGGFK---------------KMDKEQMIRQIEDVAE 62
            |.|..|||..:....:.:...:. ||.|.|||..               |:|     |..:|:..
Mosquito   372 NSNNNPAENDNGMGNSSNGLTTNGEAGGGGGGGSGSGGSSRPSPAHRTVKLD-----RTNQDIVR 431

  Fly    63 DLESQHLKEVMGISGFGRKAAKVFDINEQIEKARVTRPGMDKKREESKPKEDDQKDEEEEDVIGP 127
             |..||||::    |..|.|..:.    |.....:..|...|.|..
Mosquito   432 -LIGQHLKDI----GLERSAEMLM----QEAGCCLEHPAASKFRIH------------------- 468

  Fly   128 LPPAVTTDKEKATKESSKDEDSDD----DDYSSDEDSDDEQSL----AKRIPYTHE--------- 175
               .::.|..||      |.|..:    .|..||..|.:|...    .|.:.|..|
Mosquito   469 ---VLSGDWNKA------DHDLQELQSLVDIRSDRASLNEMKFLLLEQKYLEYLEEGRPIDALHV 524

  Fly   176 -----VQMQHGSRAVLALAGDPSGARLVSGSIDYDMCF----------WDFAGMDSSMRSFRQLQ 225
                 ..:||.:..|..|:             .|.||.          |:..|..|..|...:||
Mosquito   525 LRNELTPLQHKTPRVHQLS-------------SYMMCTNNAELYARAGWEGKGPKSRTRLMDRLQ 576

  Fly   226 P---------------------------CENHPIRSLQYSVTGDMI-LVISGNAQAKVLDRDGF- 261
            .                           |:.|   .:.:|.:.|.: |::..|..|     |||
Mosquito   577 SYLPATVMLPPRRLRSLLVQAVELQNDRCQCH---DMTWSTSIDSVSLLVDHNCSA-----DGFP 633

  Fly   262 -----------EKLECCK----------GDQ--------------YISDMSRTKGHVAQLTSGCW 291
                       :::..||          |.:              .:.:....:||...::...|
Mosquito   634 LQPLQVLNDHSDEVWFCKFSPDGRRLATGSKDNSVIVWEVDPVKLLLRNKRSFEGHTYGVSYIAW 698

  Fly   292 HPFNREQFLTAALDGTLRIWQGLKSKEQLQVIKTRAQGGLRTNAASCNFNRDATLIAAGCVDGSI 356
            .| :.:.|:....|....:|.....:|:|....:.:.....|.||   ||||.|....|...|..
Mosquito   699 SP-DSKHFIACGPDDCPDLWIWDVEQEKLVTKFSHSTDDSLTCAA---FNRDGTRFVTGGTRGQF 759

  Fly   357 ----------QTWDTRKM----FV--NTTHCVRDAH------------------QKGSEITSIVF 387
                      ..|:..::    |:  |.|....|.|                  |:...|.:...
Mosquito   760 YLVDLDGILHDNWEGVRVNGLSFLSDNKTVLAADTHYRIRGYSFDNPRTDYGIVQEQCPIMTFSV 824

  Fly   388 SYMGQQLATRSNDETMKLWDL------RQFKQPLHTWTNLFSRYDTTDCCFSPDDRLLVTGESLP 446
            :...:......:.:.:.||||      |:|:........::|       ||..     |....:.
Mosquito   825 NSADRLALLNISSQGLHLWDLQDKCLVRRFQGVTQGNYTIYS-------CFGG-----VNESFVA 877

  Fly   447 KGQAEANLYFYSTKSYEEVQRIPVSNAHVVKTL-WHPKLNQLFVSCG-NGTIKCY 499
            .|..:..:|.:..:..|.:..: :.:...|..: |:|....|..|.. :||::.:
Mosquito   878 SGSEDNKVYIWHIRREEPLATL-IGHTRTVNCVSWNPVYPALLASASDDGTVRIW 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5543	NP_611832.1	WD40	<172..519	CDD:225201	75/458 (16%)
		WD40	180..497	CDD:295369	72/432 (17%)
		WD40 repeat	185..227	CDD:293791	11/78 (14%)
		WD40 repeat	233..268	CDD:293791	8/47 (17%)
		WD40 repeat	273..329	CDD:293791	9/55 (16%)
		WD40 repeat	337..374	CDD:293791	11/52 (21%)
		WD40 repeat	382..419	CDD:293791	7/42 (17%)
		WD40 repeat	427..469	CDD:293791	6/41 (15%)
		WD40 repeat	475..497	CDD:293791	7/23 (30%)
AgaP_AGAP006042	XP_316089.4	LisH	426..455	CDD:128913	10/37 (27%)
		CTLH	464..518	CDD:128914	15/81 (19%)
		WD40	<633..931	CDD:225201	50/314 (16%)
		WD40	636..931	CDD:238121	50/311 (16%)
		WD40 repeat	648..688	CDD:293791	3/39 (8%)
		WD40 repeat	693..731	CDD:293791	7/38 (18%)
		WD40 repeat	739..773	CDD:293791	10/36 (28%)
		WD40 repeat	777..855	CDD:293791	12/77 (16%)
		WD40 repeat	864..900	CDD:293791	7/48 (15%)
		WD40 repeat	906..931	CDD:293791	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910