DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5543 and AgaP_AGAP005911

DIOPT Version :9

Sequence 1:	NP_611832.1	Gene:	CG5543 / 37768	FlyBaseID:	FBgn0034908	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_315941.1	Gene:	AgaP_AGAP005911 / 1276578	VectorBaseID:	AGAP005911	Length:	340	Species:	Anopheles gambiae

Alignment Length:	276	Identity:	55/276 - (19%)
Similarity:	98/276 - (35%)	Gaps:	63/276 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 VLALAGDPSGARLVSGSIDYDMCFWDFAGMDSSMRSFRQLQPCENHPIRSLQYSVTGDMILVISG 249
            :.|:........|||.|.|..:..|     ||...:.....|..:..:.:..|:.:|:.:
Mosquito    58 IYAMHWGSDSRNLVSASQDGKLIVW-----DSHTTNKVHAIPLRSSWVMTCAYAPSGNFV----- 112

  Fly   250 NAQAKVLDRDGFEKLECCKGDQYISDMSRTK-------------GHVAQLTSGCWHPFNREQFLT 301
                            .|.|...|..:...|             ||...|:  |....:..|.:|
Mosquito   113 ----------------ACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLS--CCRFLDDNQIVT 159

  Fly   302 AALDGTLRIWQGLKSKEQLQVIKTRAQG----GLRTNAASCNFNRDATLIAAGCVDGSIQTWDTR 362
            ::.|.:..:|.          |:|..|.    |...:..:.:.:....:..:|..|.|.:.||.|
Mosquito   160 SSGDMSCGLWD----------IETGQQCTSFLGHTGDVMALSLSPQCRVFVSGACDASAKLWDIR 214

  Fly   363 KMFVNTTHCVRDAHQKGSEITSIVFSYMGQQLATRSNDETMKLWDLRQFKQ-PLHTWTNLFSRYD 426
            :     ..|.:......|:|.::.|...|...||.|:|.|.:|:|:|..:: .:::..|:..  .
Mosquito   215 E-----GQCKQTFPGHESDINAVTFFPNGHAFATGSDDATCRLFDIRADQELAMYSHDNIIC--G 272

  Fly   427 TTDCCFSPDDRLLVTG 442
            .|...||...|||:.|
Mosquito   273 ITSVAFSKSGRLLLAG 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5543	NP_611832.1	WD40	<172..519	CDD:225201	55/276 (20%)
		WD40	180..497	CDD:295369	55/276 (20%)
		WD40 repeat	185..227	CDD:293791	9/41 (22%)
		WD40 repeat	233..268	CDD:293791	2/34 (6%)
		WD40 repeat	273..329	CDD:293791	12/68 (18%)
		WD40 repeat	337..374	CDD:293791	7/36 (19%)
		WD40 repeat	382..419	CDD:293791	11/37 (30%)
		WD40 repeat	427..469	CDD:293791	7/16 (44%)
		WD40 repeat	475..497	CDD:293791
AgaP_AGAP005911	XP_315941.1	WD40	48..340	CDD:238121	55/276 (20%)
		WD40	<49..340	CDD:225201	55/276 (20%)
		WD40 repeat	58..95	CDD:293791	9/41 (22%)
		WD40 repeat	101..141	CDD:293791	6/60 (10%)
		WD40 repeat	146..181	CDD:293791	9/46 (20%)
		WD40 repeat	188..223	CDD:293791	7/39 (18%)
		WD40 repeat	229..265	CDD:293791	11/35 (31%)
		WD40 repeat	273..309	CDD:293791	7/16 (44%)
		WD40 repeat	315..339	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910