DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5543 and WDR3

DIOPT Version :9

Sequence 1:	NP_611832.1	Gene:	CG5543 / 37768	FlyBaseID:	FBgn0034908	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_006775.1	Gene:	WDR3 / 10885	HGNCID:	12755	Length:	943	Species:	Homo sapiens

Alignment Length:	728	Identity:	139/728 - (19%)
Similarity:	250/728 - (34%)	Gaps:	247/728 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 DLESQHL--------KEVMG----------ISGFGRKAAKVFDIN--EQIEKARVTRPGMDKKRE 107
            ||::||.        .||.|          |:|......:|:||.  ::||......|   ||.:
Human   177 DLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEIEDPEEPDP---KKIK 238

  Fly   108 ESKPKEDD---------QKDEEEEDVI-------------------------GPLPPAVTTD--- 135
            .|.|...|         :.||..||.|                         |.:.....||
Human   239 GSSPGIQDTLEAEDGAFETDEAPEDRILSCRKAGSIMREGRDRVVNLAVDKTGRILACHGTDSVL 303

  Fly   136 ----------------------KEKATKESSKDEDSDDDDYSSDEDSDDEQSLAKRIPYTHEVQ- 177
                                  ::||...|||.|: :|.:.:.:....||......|..:.:::
Human   304 ELFCILSKKEIQKKMDKKMKKARKKAKLHSSKGEE-EDPEVNVEMSLQDEIQRVTNIKTSAKIKS 367

  Fly   178 -----MQHGS-RAVLALAGDPSGARLVSGSIDYDMCFWDFAGMDSSMRSFRQLQPCENHPIRSLQ 236
                 ..||. :||..|..:......::.|:.          ....:|:.|.........:|:|.
Human   368 FDLIHSPHGELKAVFLLQNNLVELYSLNPSLP----------TPQPVRTSRITIGGHRSDVRTLS 422

  Fly   237 YSVTGDMILVISGNAQA-KVLDRDGFEKLECCK--------------GDQYISDMSRT-KGHVAQ 285
            :|  .|.|.|:|..|.: |:.:|   ..|:|.:              ||:.:...::| |..:..
Human   423 FS--SDNIAVLSAAADSIKIWNR---STLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYD 482

  Fly   286 LTSG------------CW----HPFNREQFLTAALDGTLRIW------QGLKSKEQLQVIKTRAQ 328
            |.||            .|    .| ::..|:|...|.:::.|      ....::::|.|.:||..
Human   483 LASGNLLETIDAHDGALWSMSLSP-DQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTL 546

  Fly   329 GGLRTNAASCNFNRDATLIAAGCVDGSIQTW--DTRKMFVNTTHCVRDAHQKGSEITSIV--FSY 389
             .|..:....:::.:..|:|...:|.:::.:  ||.|.|::.         .|.::..|.  .|:
Human   547 -QLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSL---------YGHKLPVICMDISH 601

  Fly   390 MGQQLATRSNDETMKLWDLRQFKQPLHTWTNLFSRYDTTDC---CFSPDDRLLVTGESLPKGQAE 451
            .|..:||.|.|..:|:|.|                 |..||   .|:.||.::.. :.:||
Human   602 DGALIATGSADRNVKIWGL-----------------DFGDCHKSLFAHDDSVMYL-QFVPK---- 644

  Fly   452 ANLYFYSTKSYEEVQRIPVSNAHVVKTL--WHPKLNQLFVS-CGNGTIKCYYDEHRSIRGAKLCV 513
            ::|:|.:.|.: ::::........::||  .|.::..|.|| .|:..:...:|  :|:|
Human   645 SHLFFTAGKDH-KIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHD--KSLR------ 700

  Fly   514 VKTHRKRQPMEMVGVSQIITPHALPLFRQEKSRTSRKRMEKARMDPVKSQRPDLPITSGQGGRVA 578
             ...|.|:|:               :..:|:........|::   ..|..:|.:|      |...
Human   701 -LWERTREPL---------------ILEEEREMEREAEYEES---VAKEDQPAVP------GETQ 740

  Fly   579 SSGGTLSSYVIRNLGLSKRVDDDQDPREAILKYAKDAAE-------------------NPYWIAP 624
            ..........|..:..::|:      .|||..|.::.|:                   ||  |..
Human   741 GDSYFTGKKTIETVKAAERI------MEAIELYREETAKMKEHKAICKAAGKEVPLPSNP--ILM 797

  Fly   625 AYKQTQPKAIFSE 637
            ||....|.|...|
Human   798 AYGSISPSAYVLE 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5543	NP_611832.1	WD40	<172..519	CDD:225201	77/401 (19%)
		WD40	180..497	CDD:295369	74/365 (20%)
		WD40 repeat	185..227	CDD:293791	5/41 (12%)
		WD40 repeat	233..268	CDD:293791	12/35 (34%)
		WD40 repeat	273..329	CDD:293791	15/78 (19%)
		WD40 repeat	337..374	CDD:293791	7/38 (18%)
		WD40 repeat	382..419	CDD:293791	10/38 (26%)
		WD40 repeat	427..469	CDD:293791	10/44 (23%)
		WD40 repeat	475..497	CDD:293791	7/24 (29%)
WDR3	NP_006775.1	WD40	<21..104	CDD:225201
		WD 1	21..60
		WD40	47..>226	CDD:295369	12/48 (25%)
		WD 2	63..102
		WD40 repeat	68..104	CDD:293791
		WD40	85..698	CDD:225201	113/575 (20%)
		WD 3	105..144
		WD40 repeat	111..146	CDD:293791
		WD 4	147..186		4/8 (50%)
		WD40 repeat	152..188	CDD:293791	4/10 (40%)
		WD 5	189..228		9/38 (24%)
		WD40 repeat	194..220	CDD:293791	5/25 (20%)
		WD 6	277..316		3/38 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	326..345		7/19 (37%)
		WD40	407..703	CDD:238121	70/343 (20%)
		WD 7	413..451		12/42 (29%)
		WD40 repeat	420..454	CDD:293791	11/38 (29%)
		WD 8	453..493		7/39 (18%)
		WD40 repeat	462..494	CDD:293791	7/31 (23%)
		WD 9	494..533		6/39 (15%)
		WD40 repeat	500..548	CDD:293791	10/49 (20%)
		WD 10	547..586		8/38 (21%)
		WD40 repeat	552..588	CDD:293791	7/44 (16%)
		WD 11	589..630		14/57 (25%)
		WD40 repeat	595..630	CDD:293791	13/51 (25%)
		WD 12	631..670		7/44 (16%)
		WD40 repeat	636..672	CDD:293791	6/41 (15%)
		WD 13	673..712		11/62 (18%)
		Utp12	804..905	CDD:281932	3/7 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910