DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5543 and wdr70

DIOPT Version :9

Sequence 1:	NP_611832.1	Gene:	CG5543 / 37768	FlyBaseID:	FBgn0034908	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_021334902.1	Gene:	wdr70 / 101884837	-ID:	-	Length:	637	Species:	Danio rerio

Alignment Length:	644	Identity:	313/644 - (48%)
Similarity:	421/644 - (65%)	Gaps:	54/644 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 MIRQIEDVAEDLESQHLKEVMGISGFGRKAAKVFDINEQIEKARVT-------------RPGMDK 104
            |..|..|...|.:   |..|||.|||||| |:.||:....|:.|.|             :..:::
Zfish     1 MADQSSDAGADGD---LSSVMGFSGFGRK-ARTFDLEAMFEQTRRTAIERSQRVLEDREKQELEE 61

  Fly   105 KREESKP----KEDDQKDEEEEDVIGPLPPAVTTDKEKATKE----------------------S 143
            .|::.||    |:....||.:.||||||||....|.|....:                      |
Zfish    62 SRQKEKPSTSRKQQPDSDESDSDVIGPLPPPAQADDEDDDDDDEDDDDDDDGVVGPPLPPGFMRS 126

  Fly   144 SKDEDSDDDDYSSDEDSDDEQSLAKRIPYTHEVQMQHGSRAVLALAGDPSGARLVSGSIDYDMCF 208
            :.|||.|:|....::|.||:.:..|:||.|||:.:|||::.|.|||.||||||||:|..|||:.|
Zfish   127 TADEDDDEDGNEDEDDDDDDDNPVKKIPDTHEITLQHGTKTVSALALDPSGARLVTGGYDYDVRF 191

  Fly   209 WDFAGMDSSMRSFRQLQPCENHPIRSLQYSVTGDMILVISGNAQAKVLDRDGFEKLECCKGDQYI 273
            |||||||:::.:||.|||||.|.|::||||:|||:|||::||:||||||||||:.|||.||||||
Zfish   192 WDFAGMDANLHAFRSLQPCECHQIKALQYSITGDVILVVAGNSQAKVLDRDGFQVLECIKGDQYI 256

  Fly   274 SDMSRTKGHVAQLTSGCWHPFNREQFLTAALDGTLRIWQGLKSKEQLQVIKTRAQGGLRTNAASC 338
            .||:.||||.|.|..|||||..:|:|||.:.|||:|.|.....|:...|.|.|:|.|.|.....|
Zfish   257 VDMANTKGHTAMLNDGCWHPKIKEEFLTCSNDGTVRTWDLTSEKKHKSVFKPRSQQGKRVTPTCC 321

  Fly   339 NFNRDATLIAAGCVDGSIQTWDTRKMFVNTT-HCVRDAHQKGSEITSIVFSYMGQQLATRSNDET 402
            .::||..||||||.||:||.|| |.:.|:|. || |.||..||:.:|:.|||.|..||:|..|:|
Zfish   322 TYSRDGKLIAAGCQDGTIQIWD-RNLSVHTKFHC-RQAHAPGSDTSSLCFSYDGVTLASRGGDDT 384

  Fly   403 MKLWDLRQFKQPLHTWTNLFSRYDTTDCCFSPDDRLLVTGESLPKGQAEANLYFYSTKSYEEVQR 467
            :|.||:|.|:.||:..|.|.|.:..|||||||||:|||||.|:.|.:.:..|.|:..::.:::..
Zfish   385 LKTWDIRSFRSPLNVATGLTSFFPMTDCCFSPDDKLLVTGTSVRKDEGQGKLLFFQRETLQKLYE 449

  Fly   468 IPVSNAHVVKTLWHPKLNQLFVSCGNGTIKCYYDEHRSIRGAKLCVVKTHRKRQPMEMVGVSQII 532
            |.|::|.||:.||||||||:.|..|||..|.|||..:|.|||.|||||:.||.:..|.:....||
Zfish   450 IEVADASVVRCLWHPKLNQIMVGTGNGLAKVYYDPVKSQRGAILCVVKSKRKEKHAETLTQDYII 514

  Fly   533 TPHALPLFRQEKSRTSRKRMEKARMDPVKSQRPDLPITS-GQGGRVASSGGTLSSYVIRNLGLSK 596
            ||||||:||:.:.|::||::||.|:||:||.:|:.|::. |:|||||:.||||||::::|:.|.|
Zfish   515 TPHALPMFREARQRSTRKQLEKDRLDPLKSHKPEPPVSGPGRGGRVAAHGGTLSSFIVKNIALDK 579

  Fly   597 RVDDDQDPREAILKYAKDAAENPYWIAPAYKQTQPKAIFSEKL-----PADEPATKKPK 650
              .||.:||||||::||:||:||||:|||||:||||.:|:|:.     ..|||..||.|
Zfish   580 --TDDSNPREAILRHAKEAADNPYWVAPAYKKTQPKPLFAEEEEEEEDDKDEPEWKKRK 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5543	NP_611832.1	WD40	<172..519	CDD:225201	192/347 (55%)
		WD40	180..497	CDD:295369	175/317 (55%)
		WD40 repeat	185..227	CDD:293791	28/41 (68%)
		WD40 repeat	233..268	CDD:293791	25/34 (74%)
		WD40 repeat	273..329	CDD:293791	27/55 (49%)
		WD40 repeat	337..374	CDD:293791	20/37 (54%)
		WD40 repeat	382..419	CDD:293791	17/36 (47%)
		WD40 repeat	427..469	CDD:293791	18/41 (44%)
		WD40 repeat	475..497	CDD:293791	14/21 (67%)
wdr70	XP_021334902.1	U79_P34	<12..84	CDD:281109	22/75 (29%)
		WD40	160..481	CDD:330360	177/322 (55%)
		WD40 repeat	168..212	CDD:293791	30/43 (70%)
		WD40 repeat	216..264	CDD:293791	34/47 (72%)
		WD40 repeat	269..307	CDD:293791	17/37 (46%)
		WD40 repeat	317..351	CDD:293791	17/34 (50%)
		WD40 repeat	364..401	CDD:293791	17/36 (47%)
		WD40 repeat	409..451	CDD:293791	18/41 (44%)
		WD40 repeat	458..481	CDD:293791	14/22 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H9972
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177718at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010