DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ssrp and POB3

DIOPT Version :9

Sequence 1:	NP_523830.2	Gene:	Ssrp / 37767	FlyBaseID:	FBgn0010278	Length:	723	Species:	Drosophila melanogaster
Sequence 2:	NP_013642.1	Gene:	POB3 / 854933	SGDID:	S000004534	Length:	552	Species:	Saccharomyces cerevisiae

Alignment Length:	559	Identity:	171/559 - (30%)
Similarity:	280/559 - (50%)	Gaps:	80/559 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SGRLKMTEQNIIFKNTKTG--------KVEQISAEDIDLINSQKFVGTWGLRVFTKGGVLHRFTG 76
            |||.::.:..:.:|.:.:|        |...:.|.::..:...:....:.|::.||...:.:..|
Yeast    16 SGRFRIADSGLGWKISTSGGSAANQARKPFLLPATELSTVQWSRGCRGYDLKINTKNQGVIQLDG 80

  Fly    77 FRDSEHEKLGKFIKAAYSQEMVEKEMCVKGWNWGTARFMGSVLSFDKESKTIFEVPLSHVSQC-V 140
            |...::..:.......::.::.::|..::|||||......:.:.|....|..||:|.:.::.. :
Yeast    81 FSQDDYNLIKNDFHRRFNIQVEQREHSLRGWNWGKTDLARNEMVFALNGKPTFEIPYARINNTNL 145

  Fly   141 TGKNEVTLEFHQNDD--APVG--LLEMRFHIPAV-------------ESA--------------- 173
            |.||||.:||:..|:  .|.|  |:||||:||.|             ||:
Yeast   146 TSKNEVGIEFNIQDEEYQPAGDELVEMRFYIPGVIQTNVDENMTKKEESSNEVVPKKEDGAEGED 210

  Fly   174 ------EEDPVDKFHQNVMSKASVISASGESIAIFREIQILTPRGRYDIKIFSTFFQLHGKTFDY 232
                  |:...:.|::.:..||.:...:|::|..|:::...||||||||.|:....:|.|||::|
Yeast   211 VQMAVEEKSMAEAFYEELKEKADIGEVAGDAIVSFQDVFFTTPRGRYDIDIYKNSIRLRGKTYEY 275

  Fly   233 KIPMDSVLRLFMLPHKDSRQMFFVLSLDPPIKQGQTRYHYLVLLFAPDEETTIELPFSEAELRDK 297
            |:....:.|:..||..|......||:::||::||||.|.:|||.|..||||.::|...:.:..:.
Yeast   276 KLQHRQIQRIVSLPKADDIHHLLVLAIEPPLRQGQTTYPFLVLQFQKDEETEVQLNLEDEDYEEN 340

  Fly   298 YEGKLEKEISGPVYEVMGKVMKVLIGRKITGPGNFIGHSGTAAVGCSFKAAAGYLYPLERGFIYI 362
            |:.||:|:.....:.|:..|:|.|..|::..||.:.......||.|||||..||||||:..|.::
Yeast   341 YKDKLKKQYDAKTHIVLSHVLKGLTDRRVIVPGEYKSKYDQCAVSCSFKANEGYLYPLDNAFFFL 405

  Fly   363 HKPPLHIRFEEISSVNFARSG---GSTRSFDFEVTLK-NGTVHIFSSIEKEEYAKLFDYITQKKL 423
            .||.|:|.|.::|.||.:|:|   .|:|:||.||.|: |.....|::|.|||...|..::..|.|
Yeast   406 TKPTLYIPFSDVSMVNISRAGQTSTSSRTFDLEVVLRSNRGSTTFANISKEEQQLLEQFLKSKNL 470

  Fly   424 HVSNMGKDKSGYKDVDFG-DSDNENEPDAYLARLKAEAREKEEDDDDGDS--DEESTDEDFK-PN 484
            .|.|..::.........| |||                   |||.:.|.:  |:||.||||: .:
Yeast   471 RVKNEDREVQERLQTALGSDSD-------------------EEDINMGSAGEDDESVDEDFQVSS 516

  Fly   485 ENESD-VAEEYDSNVESDSDDDSDASGGGGDSDGAKKKK 522
            :|::| ||||:||:...     |||.||..:...:||.|
Yeast   517 DNDADEVAEEFDSDAAL-----SDAEGGSDEERPSKKPK 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssrp	NP_523830.2	POB3	20..499	CDD:227494	163/534 (31%)
		SSrecog	75..284	CDD:281523	75/247 (30%)
		PH2_SSRP1-like	332..427	CDD:270051	41/98 (42%)
		HMG_box	557..620	CDD:278906
POB3	NP_013642.1	POB3	1..546	CDD:227494	168/553 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	122	1.000	Domainoid score	I1245
eggNOG	1	0.900	-	-		E1_COG5165
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	259	1.000	Inparanoid score	I635
Isobase	1	0.950	-	0	Normalized mean entropy	S1176
OMA	1	1.010	-	-		QHG54838
OrthoFinder	1	1.000	-	-		FOG0003358
OrthoInspector	1	1.000	-	-		oto100161
orthoMCL	1	0.900	-	-		OOG6_101807
Panther	1	1.100	-	-	LDO	PTHR45849
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R946
SonicParanoid	1	1.000	-	-		X2245
TreeFam	1	0.960	-	-
	14	13.810