DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ssrp and Ssrp1

DIOPT Version :9

Sequence 1:	NP_523830.2	Gene:	Ssrp / 37767	FlyBaseID:	FBgn0010278	Length:	723	Species:	Drosophila melanogaster
Sequence 2:	XP_038961847.1	Gene:	Ssrp1 / 81785	RGDID:	621143	Length:	805	Species:	Rattus norvegicus

Alignment Length:	745	Identity:	375/745 - (50%)
Similarity:	506/745 - (67%)	Gaps:	63/745 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTDSLEYNDINAEVRGVLCSGRLKMTEQNIIFKNTKTGKVEQISAEDIDLINSQKFVGTW----- 60
            |.::||:|||..||:|.:..|||:::.|.|||||:|||||:.|.|.::.       .|.|
  Rat    94 MAETLEFNDIFQEVKGSMNDGRLRLSRQGIIFKNSKTGKVDNIQAGELT-------EGIWRRVAL 151

  Fly    61 --GLRVFTKGGVLHRFTGFRDSEHEKLGKFIKAAYSQEMVEKEMCVKGWNWGTARFMGSVLSFDK 123
              ||::.||.|.::::.|||:||.|||..|.|..|..|::||::|||||||||.:|.|.:||||.
  Rat   152 GHGLKLLTKNGHVYKYDGFRESEFEKLSDFFKTHYRLELMEKDLCVKGWNWGTVKFGGQLLSFDI 216

  Fly   124 ESKTIFEVPLSHVSQCVTGKNEVTLEFHQNDDAPVGLLEMRFHIPAVESAEEDPVDKFHQNVMSK 188
            ..:.:||:|||:||||.||||||||||||||||.|.|:|:||::|..:....|||:.|.|||:||
  Rat   217 GDQPVFEIPLSNVSQCTTGKNEVTLEFHQNDDAEVSLMEVRFYVPPTQEDGVDPVEAFAQNVLSK 281

  Fly   189 ASVISASGESIAIFREIQILTPRGRYDIKIFSTFFQLHGKTFDYKIPMDSVLRLFMLPHKDSRQM 253
            |.||.|:|::|.||||:|.|||||||||:|:.||..|||||||||||..:|||||:|||||.|||
  Rat   282 ADVIQATGDAICIFRELQCLTPRGRYDIRIYPTFLHLHGKTFDYKIPYTTVLRLFLLPHKDQRQM 346

  Fly   254 FFVLSLDPPIKQGQTRYHYLVLLFAPDEETTIELPFSEAELRDKYEGKLEKEISGPVYEVMGKVM 318
            |||:||||||||||||||:|:|||:.||:.::.|..:|.|:..::||:|.|.:||.:||::.:||
  Rat   347 FFVISLDPPIKQGQTRYHFLILLFSKDEDISLTLNMNEEEVEKRFEGRLTKNMSGSLYEMVSRVM 411

  Fly   319 KVLIGRKITGPGNFIGHSGTAAVGCSFKAAAGYLYPLERGFIYIHKPPLHIRFEEISSVNFARSG 383
            |.|:.||||.||||.||||...:.||:||::|.||||||||||:||||:||||:|||.|||||..
  Rat   412 KALVNRKITVPGNFQGHSGAQCITCSYKASSGLLYPLERGFIYVHKPPVHIRFDEISFVNFARGT 476

  Fly   384 GSTRSFDFEVTLKNGTVHIFSSIEKEEYAKLFDYITQKKLHVSNMG-KDKS-----GYKDVDFGD 442
            .:|||||||:..|.||.:.|||||:|||.||||::..|||::.|.| |:|.     ||.  |:.|
  Rat   477 TTTRSFDFEIETKQGTQYTFSSIEREEYGKLFDFVNAKKLNIKNRGLKEKKEGINPGYD--DYAD 539

  Fly   443 SDNENEPDAYLARLKAEAREKEED-DDDGDSDEESTDEDFKPNENESDVAEEYDSNVESDSDDDS 506
            || |::.||||.|:|.|.:.:||: :|..|...|.|||.|.|.|.|.|||||:|||..:.|
  Rat   540 SD-EDQHDAYLERMKEEGKIREENANDSSDDSGEETDESFNPGEEEEDVAEEFDSNASASS---- 599

  Fly   507 DASGGGGDSDGAKKKKEKKSEKKEKKEKKHKEKERTKKPS--KKKKDSGKPKRATTAFMLWLNDT 569
              |...||||     :|:|..|:.|:.|..|:::..||.|  ||.||...|||..:|:|||||.:
  Rat   600 --SSNEGDSD-----REEKKRKQLKRAKMAKDRKSRKKSSEGKKGKDPNAPKRPMSAYMLWLNAS 657

  Fly   570 RESIKRENPGIKVTEIAKKGGEMWKEL--KDKSKWEDAAAKDKQRYHDEMRNYKPEAGGDSDNEK 632
            ||.||.::|||.:|:::||.||:||.:  :.|.:|:..|...::.|...|:.|:   ||..|:.|
  Rat   658 REKIKSDHPGISITDLSKKAGEIWKGMSKEKKEEWDRKAEDARREYEKAMKEYE---GGRGDSSK 719

  Fly   633 GGKSSKKRKTEPSPSKKANTS-GS-----------GFKSKEYISDDDSTSSDDEKDNEPAKKKSK 685
            ..||.||:|.:....||:..| ||           .|||||::|.|:|:|.:::     :|||.:
  Rat   720 RDKSKKKKKVKAKLEKKSTPSRGSSSKSSSRQLSDSFKSKEFVSSDESSSGENK-----SKKKRR 779

  Fly   686 PPSDGDAKKKKAKSESEPEESEEDSNASDE 715
            ...|.|    :.:..|.|..||:.::.|||
  Rat   780 RSEDSD----EEELASTPPSSEDSASGSDE 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssrp	NP_523830.2	POB3	20..499	CDD:227494	283/492 (58%)
		SSrecog	75..284	CDD:281523	139/208 (67%)
		PH2_SSRP1-like	332..427	CDD:270051	61/94 (65%)
		HMG_box	557..620	CDD:278906	26/64 (41%)
Ssrp1	XP_038961847.1	POB3	114..576	CDD:227494	269/471 (57%)
Ssrp1	XP_038961847.1	HMG_box	643..710	CDD:395407	28/66 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	229	1.000	Domainoid score	I2381
eggNOG	1	0.900	-	-		E1_COG5165
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H110735
Inparanoid	1	1.050	718	1.000	Inparanoid score	I608
OMA	1	1.010	-	-		QHG54838
OrthoDB	1	1.010	-	-		D244836at33208
OrthoFinder	1	1.000	-	-		FOG0003358
OrthoInspector	1	1.000	-	-		oto98363
orthoMCL	1	0.900	-	-		OOG6_101807
Panther	1	1.100	-	-	LDO	PTHR45849
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2245
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.880