DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ssrp and SSRP1

DIOPT Version :9

Sequence 1:	NP_523830.2	Gene:	Ssrp / 37767	FlyBaseID:	FBgn0010278	Length:	723	Species:	Drosophila melanogaster
Sequence 2:	XP_024304432.1	Gene:	SSRP1 / 6749	HGNCID:	11327	Length:	938	Species:	Homo sapiens

Alignment Length:	842	Identity:	374/842 - (44%)
Similarity:	505/842 - (59%)	Gaps:	165/842 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTDSLEYNDINAEVRGVLCSGRLKMTEQNIIFKNTKTGKVEQISAEDIDLINSQKFVGTW----- 60
            |.::||:||:..||:|.:..|||:::.|.|||||:|||||:.|.|.::.       .|.|
Human   135 MAETLEFNDVYQEVKGSMNDGRLRLSRQGIIFKNSKTGKVDNIQAGELT-------EGIWRRVAL 192

  Fly    61 --GLRVFTKGGVLHRFTGFRDSEHEKLGKFIKAAYSQEMVEKEMCVKGWNWGTARF--------- 114
              ||::.||.|.::::.|||:||.|||..|.|..|..|::||::|||||||||.:|
Human   193 GHGLKLLTKNGHVYKYDGFRESEFEKLSDFFKTHYRLELMEKDLCVKGWNWGTVKFGGESWGRLR 257

  Fly   115 ----------------------------------------------------------------- 114

Human   258 FGEEDRVKGFSLLLVLLFSLCHCLWFPIYLHVHHVFIEYLQYTAWGWGYSLNRLTAVSCLCGTQF 322

  Fly   115 ---------------------MGSVLSFDKESKTIFEVPLSHVSQCVTGKNEVTLEFHQNDDAPV 158
                                 .|.:||||...:.:||:|||:||||.||||||||||||||||.|
Human   323 GGNIAYADLRGGACGWISPFLTGQLLSFDIGDQPVFEIPLSNVSQCTTGKNEVTLEFHQNDDAEV 387

  Fly   159 GLLEMRFHIPAVESAEEDPVDKFHQNVMSKASVISASGESIAIFREIQILTPRGRYDIKIFSTFF 223
            .|:|:||::|..:....|||:.|.|||:|||.||.|:|::|.||||:|.|||||||||:|:.||.
Human   388 SLMEVRFYVPPTQEDGVDPVEAFAQNVLSKADVIQATGDAICIFRELQCLTPRGRYDIRIYPTFL 452

  Fly   224 QLHGKTFDYKIPMDSVLRLFMLPHKDSRQMFFVLSLDPPIKQGQTRYHYLVLLFAPDEETTIELP 288
            .|||||||||||..:|||||:|||||.||||||:||||||||||||||:|:|||:.||:.::.|.
Human   453 HLHGKTFDYKIPYTTVLRLFLLPHKDQRQMFFVISLDPPIKQGQTRYHFLILLFSKDEDISLTLN 517

  Fly   289 FSEAELRDKYEGKLEKEISGPVYEVMGKVMKVLIGRKITGPGNFIGHSGTAAVGCSFKAAAGYLY 353
            .:|.|:..::||:|.|.:||.:||::.:|||.|:.||||.||||.||||...:.||:||::|.||
Human   518 MNEEEVEKRFEGRLTKNMSGSLYEMVSRVMKALVNRKITVPGNFQGHSGAQCITCSYKASSGLLY 582

  Fly   354 PLERGFIYIHKPPLHIRFEEISSVNFARSGGSTRSFDFEVTLKNGTVHIFSSIEKEEYAKLFDYI 418
            ||||||||:||||:||||:|||.|||||...:|||||||:..|.||.:.|||||:|||.||||::
Human   583 PLERGFIYVHKPPVHIRFDEISFVNFARGTTTTRSFDFEIETKQGTQYTFSSIEREEYGKLFDFV 647

  Fly   419 TQKKLHVSNMG-KDKSGYKDVDFGDSDNENEPDAYLARLKAEAREKEED-DDDGDSDEESTDEDF 481
            ..|||::.|.| |:.......::.||| |::.||||.|:|.|.:.:||: :|..|...|.|||.|
Human   648 NAKKLNIKNRGLKEGMNPSYDEYADSD-EDQHDAYLERMKEEGKIREENANDSSDDSGEETDESF 711

  Fly   482 KPNENESDVAEEYDSNVESDSDDDSDASGGGGDSDGAKKKKEKKSEKKEKKEKKHKEKERTKKP- 545
            .|.|.|.|||||:|||..:.|      |...||||     :::|..|:.||.|..|:::..|||
Human   712 NPGEEEEDVAEEFDSNASASS------SSNEGDSD-----RDEKKRKQLKKAKMAKDRKSRKKPV 765

  Fly   546 -SKKKKDSGKPKRATTAFMLWLNDTRESIKRENPGIKVTEIAKKGGEMWKEL-KDKSKWEDAAAK 608
             .||.||...|||..:|:|||||.:||.||.::|||.:|:::||.||:||.: |:|.:..|..|:
Human   766 EVKKGKDPNAPKRPMSAYMLWLNASREKIKSDHPGISITDLSKKAGEIWKGMSKEKKEEWDRKAE 830

  Fly   609 DKQR-YHDEMRNYKPEAGGDSDNEKGGKSSKKRKTEPSPSKKANTS-GS-----------GFKSK 660
            |.:| |...|:.|:   ||..::.|..||.||:|.:....||:..| ||           .||||
Human   831 DARRDYEKAMKEYE---GGRGESSKRDKSKKKKKVKVKMEKKSTPSRGSSSKSSSRQLSESFKSK 892

  Fly   661 EYISDDDSTSSDDEKDNEPAKKKSKPPSDGDAKKKKAKSESEPEE-------SEEDSNASDE 715
            |::|.|:|:|.::         |||       ||::...:||.||       ||:.::.|||
Human   893 EFVSSDESSSGEN---------KSK-------KKRRRSEDSEEEELASTPPSSEDSASGSDE 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssrp	NP_523830.2	POB3	20..499	CDD:227494	279/582 (48%)
		SSrecog	75..284	CDD:281523	139/303 (46%)
		PH2_SSRP1-like	332..427	CDD:270051	61/94 (65%)
		HMG_box	557..620	CDD:278906	29/64 (45%)
SSRP1	XP_024304432.1	POB3	155..709	CDD:227494	265/561 (47%)
		SSrecog	209..513	CDD:308895	139/303 (46%)
		HMG_box	776..843	CDD:278906	31/66 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2465
eggNOG	1	0.900	-	-		E1_COG5165
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H110735
Inparanoid	1	1.050	713	1.000	Inparanoid score	I645
Isobase	1	0.950	-	0	Normalized mean entropy	S1176
OMA	1	1.010	-	-		QHG54838
OrthoDB	1	1.010	-	-		D244836at33208
OrthoFinder	1	1.000	-	-		FOG0003358
OrthoInspector	1	1.000	-	-		oto91280
orthoMCL	1	0.900	-	-		OOG6_101807
Panther	1	1.100	-	-	LDO	PTHR45849
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2245
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790