DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ssrp and ssrp1a

DIOPT Version :9

Sequence 1:	NP_523830.2	Gene:	Ssrp / 37767	FlyBaseID:	FBgn0010278	Length:	723	Species:	Drosophila melanogaster
Sequence 2:	NP_997967.2	Gene:	ssrp1a / 386844	ZFINID:	ZDB-GENE-031118-9	Length:	705	Species:	Danio rerio

Alignment Length:	723	Identity:	374/723 - (51%)
Similarity:	504/723 - (69%)	Gaps:	30/723 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTDSLEYNDINAEVRGVLCSGRLKMTEQNIIFKNTKTGKVEQISAEDIDLINSQKFVGTWGLRVF 65
            |.|:||:|||:.||:|....|||:.::|.:::|:.|||||:.|.|.|:.....::.....||::.
Zfish     1 MGDTLEFNDIHQEVKGSWNDGRLRFSKQTVVYKSHKTGKVDSIPAPDLSEAQWRRVCLGHGLKLA 65

  Fly    66 TKGGVLHRFTGFRDSEHEKLGKFIKAAYSQEMVEKEMCVKGWNWGTARFMGSVLSFDKESKTIFE 130
            |..|.::::.||:::::||:..|.||.|..|:.||:|||||||||||:|.||:||||.....:||
Zfish    66 TSTGHIYKYDGFKETDYEKISAFFKANYKVELEEKDMCVKGWNWGTAKFAGSLLSFDVSDSPVFE 130

  Fly   131 VPLSHVSQCVTGKNEVTLEFHQNDDAPVGLLEMRFHIPAVESAE-EDPVDKFHQNVMSKASVISA 194
            :|||.||||.|||||||:||||||||.|.|:|:||::|.....: .|||:.|.||::|||.||.|
Zfish   131 IPLSSVSQCATGKNEVTVEFHQNDDAEVSLMEVRFYVPPNTGDDGSDPVEAFAQNILSKADVIQA 195

  Fly   195 SGESIAIFREIQILTPRGRYDIKIFSTFFQLHGKTFDYKIPMDSVLRLFMLPHKDSRQMFFVLSL 259
            :|:::.||:|:|.|||||||||:|:.||..|||||||||||..:|||||:|||||.||||||:||
Zfish   196 TGDAVCIFKELQCLTPRGRYDIRIYPTFLHLHGKTFDYKIPYTTVLRLFLLPHKDQRQMFFVISL 260

  Fly   260 DPPIKQGQTRYHYLVLLFAPDEETTIELPFSEAELRDKYEGKLEKEISGPVYEVMGKVMKVLIGR 324
            ||||||||||||:|:|||:.||:.::.|..||.|:..:|||||.|.:|||:||::.:|||.|:.|
Zfish   261 DPPIKQGQTRYHFLILLFSKDEDISLALNMSEDEVEKRYEGKLSKNMSGPLYEIVSRVMKALVNR 325

  Fly   325 KITGPGNFIGHSGTAAVGCSFKAAAGYLYPLERGFIYIHKPPLHIRFEEISSVNFARSGGSTRSF 389
            |||.||||.||||:..:.|::||::|.||||||||||:||||:|:||||||.|||||...:||||
Zfish   326 KITVPGNFQGHSGSQCITCAYKASSGLLYPLERGFIYVHKPPVHLRFEEISCVNFARGTTTTRSF 390

  Fly   390 DFEVTLKNGTVHIFSSIEKEEYAKLFDYITQKKLHVSNMGKDKSGYKDV-DFGDSDNENEPDAYL 453
            |||:..|......||:||:|||.||||::..|||.:.|.| .|.|.|.. |:.||| |::.||||
Zfish   391 DFEIETKQNNQFTFSNIEREEYGKLFDFVNAKKLTIKNRG-FKEGMKGAEDYSDSD-EDQHDAYL 453

  Fly   454 ARLKAEAREKEEDDDDGDSDEESTDEDFKPNENESDVAEEYDSNVESDSDDDSDASGGGGDSDGA 518
            .|:|.|.:.:||.|...||:.:| ||.|.|.|.:.||.||||||.   |..||:...|..:.:|.
Zfish   454 ERMKEEGKIREEGDGSDDSEGDS-DESFNPGEEDDDVPEEYDSNA---SVSDSEGDDGDSEDEGK 514

  Fly   519 KKKKEKKSEK--KEKKEKKHKEKERTKKPSKKKKDSGKPKRATTAFMLWLNDTRESIKRENPGIK 581
            |||.|||.:|  |||||:|.:::       ||.||:..|||..:|:|||||..||.||.|||||.
Zfish   515 KKKVEKKPKKVVKEKKERKPRKE-------KKVKDAAAPKRPMSAYMLWLNGNRERIKSENPGIS 572

  Fly   582 VTEIAKKGGEMWKEL-KD-KSKWEDAAAKDKQRYHDEMRNYKPEAGG-----DSDNEKGGKSSKK 639
            :|||:||.|||||:| || |.:|:..|.:.|::|...|:.||...||     ....:||||...|
Zfish   573 ITEISKKAGEMWKQLGKDKKEEWDKKAEEAKRQYEKAMKEYKESGGGAAAATKEKKKKGGKVEAK 637

  Fly   640 RKTEPSPSKKANTSGSGFKSKEYISDDDSTSSDDEKDNEPAKKKSKPPSDGDAKKKKAKSESEPE 704
            :|:.....||.......|||||:||.::|:|..|.  :..:|:|:   ||.|.::::| :.|.|.
Zfish   638 KKSGGEKEKKKEGGNDSFKSKEFISSEESSSESDH--DRGSKRKA---SDDDDEEEEA-AASTPA 696

  Fly   705 ESEEDSNA 712
            .|||:|.:
Zfish   697 SSEEESGS 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssrp	NP_523830.2	POB3	20..499	CDD:227494	271/480 (56%)
		SSrecog	75..284	CDD:281523	135/209 (65%)
		PH2_SSRP1-like	332..427	CDD:270051	57/94 (61%)
		HMG_box	557..620	CDD:278906	35/64 (55%)
ssrp1a	NP_997967.2	POB3	21..512	CDD:227494	275/496 (55%)
		SSrecog	75..285	CDD:281523	135/209 (65%)
		PH2_SSRP1-like	333..428	CDD:270051	57/94 (61%)
		HMG_box	546..613	CDD:278906	37/66 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	237	1.000	Domainoid score	I2254
eggNOG	1	0.900	-	-		E1_COG5165
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	707	1.000	Inparanoid score	I639
OMA	1	1.010	-	-		QHG54838
OrthoDB	1	1.010	-	-		D244836at33208
OrthoFinder	1	1.000	-	-		FOG0003358
OrthoInspector	1	1.000	-	-		otm24768
orthoMCL	1	0.900	-	-		OOG6_101807
Panther	1	1.100	-	-	O	PTHR45849
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R946
SonicParanoid	1	1.000	-	-		X2245
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870