DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ssrp and HMGB2

DIOPT Version :9

Sequence 1:	NP_523830.2	Gene:	Ssrp / 37767	FlyBaseID:	FBgn0010278	Length:	723	Species:	Drosophila melanogaster
Sequence 2:	NP_001124160.1	Gene:	HMGB2 / 3148	HGNCID:	5000	Length:	209	Species:	Homo sapiens

Alignment Length:	211	Identity:	64/211 - (30%)
Similarity:	90/211 - (42%)	Gaps:	66/211 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   521 KKEKKSEKKEKKEKKHKEKE-RTKKPSK-----KKKDSGKPKRATTAFMLWLNDTRESIKRENPG 579
            |::.|.|...|.:|...::| :...|.|     ||||...|||..:||.|:.::.|..||.|:||
Human    55 KEKSKFEDMAKSDKARYDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPG 119

  Fly   580 IKVTEIAKKGGEMWKE--LKDKSKWEDAAAKDKQRYHDEMRNYKPEAGGDSDNEKGGKSSKKRKT 642
            :.:.:.|||.||||.|  .|||..:|..|||.|::|..::..|:  |.|.|:      :.||...
Human   120 LSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYR--AKGKSE------AGKKGPG 176

  Fly   643 EPSPSKKANTSGSGFKSKEYISDDDSTSSDDEKDNEPAKKKSKPPSDGDAKKKKAKSESEPEESE 707
            .|:.|||.|                                                  |||:.|
Human   177 RPTGSKKKN--------------------------------------------------EPEDEE 191

  Fly   708 EDSNASDEDEEDEASD 723
            |:....|||||:|..|
Human   192 EEEEEEDEDEEEEDED 207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssrp	NP_523830.2	POB3	20..499	CDD:227494
		SSrecog	75..284	CDD:281523
		PH2_SSRP1-like	332..427	CDD:270051
		HMG_box	557..620	CDD:278906	27/64 (42%)
HMGB2	NP_001124160.1	HMG_box_2	6..78	CDD:401091	6/22 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	52..150		37/94 (39%)
		HMG_box	95..162	CDD:395407	29/66 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..209		23/104 (22%)
		Required for chemotactic activity. /evidence=ECO:0000269\|PubMed:19811285	165..180		5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910