DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ssrp and Ssrp1

DIOPT Version :9

Sequence 1:	NP_523830.2	Gene:	Ssrp / 37767	FlyBaseID:	FBgn0010278	Length:	723	Species:	Drosophila melanogaster
Sequence 2:	NP_001129553.1	Gene:	Ssrp1 / 20833	MGIID:	107912	Length:	708	Species:	Mus musculus

Alignment Length:	747	Identity:	371/747 - (49%)
Similarity:	501/747 - (67%)	Gaps:	71/747 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTDSLEYNDINAEVRGVLCSGRLKMTEQNIIFKNTKTGKVEQISAEDIDLINSQKFVGTW----- 60
            |.::||:|||..||:|.:..|||:::.|.|||||:|||||:.|.|.::.       .|.|
Mouse     1 MAETLEFNDIFQEVKGSMNDGRLRLSRQGIIFKNSKTGKVDNIQAGELT-------EGIWRRVAL 58

  Fly    61 --GLRVFTKGGVLHRFTGFRDSEHEKLGKFIKAAYSQEMVEKEMCVKGWNWGTARFMGSVLSFDK 123
              ||::.||.|.::::.|||:||.|||..|.|..|..|::||::|||||||||.:|.|.:||||.
Mouse    59 GHGLKLLTKNGHVYKYDGFRESEFEKLSDFFKTHYRLELMEKDLCVKGWNWGTVKFGGQLLSFDI 123

  Fly   124 ESKTIFEVPLSHVSQCVTGKNEVTLEFHQNDDAPVGLLEMRFHIPAVESAEEDPVDKFHQNVMSK 188
            ..:.:||:|||:||||.||||||||||||||||.|.|:|:||::|..:....|||:.|.|||:||
Mouse   124 GDQPVFEIPLSNVSQCTTGKNEVTLEFHQNDDAEVSLMEVRFYVPPTQEDGVDPVEAFAQNVLSK 188

  Fly   189 ASVISASGESIAIFREIQILTPRGRYDIKIFSTFFQLHGKTFDYKIPMDSVLRLFMLPHKDSRQM 253
            |.||.|:|::|.||||:|.|||||||||:|:.||..|||||||||||..:|||||:|||||.|||
Mouse   189 ADVIQATGDAICIFRELQCLTPRGRYDIRIYPTFLHLHGKTFDYKIPYTTVLRLFLLPHKDQRQM 253

  Fly   254 FFVLSLDPPIKQGQTRYHYLVLLFAPDEETTIELPFSEAELRDKYEGKLEKEISGPVYEVMGKVM 318
            |||:||||||||||||||:|:|||:.||:.::.|..:|.|:..::||:|.|.:||.:||::.:||
Mouse   254 FFVISLDPPIKQGQTRYHFLILLFSKDEDISLTLNMNEEEVEKRFEGRLTKNMSGSLYEMVSRVM 318

  Fly   319 KVLIGRKITGPGNFIGHSGTAAVGCSFKAAAGYLYPLERGFIYIHKPPLHIRFEEISSVNFARSG 383
            |.|:.||||.||||.||||...:.||:||::|.||||||||||:||||:||||:|||.|||||..
Mouse   319 KALVNRKITVPGNFQGHSGAQCITCSYKASSGLLYPLERGFIYVHKPPVHIRFDEISFVNFARGT 383

  Fly   384 GSTRSFDFEVTLKNGTVHIFSSIEKEEYAKLFDYITQKKLHVSNMGKDKS---GYKDVDFGDSDN 445
            .:|||||||:..|.||.:.|||||:|||.||||::..|||::.|.|..:.   ||.  |:.|||
Mouse   384 TTTRSFDFEIETKQGTQYTFSSIEREEYGKLFDFVNAKKLNIKNRGLKEGINPGYD--DYADSD- 445

  Fly   446 ENEPDAYLARLKAEAREKEED-DDDGDSDEESTDEDFKPNENESDVAEEYDSNVESDSDDDSDAS 509
            |::.||||.|:|.|.:.:||: :|..|...|.|||.|.|.|.|.|||||:|||..:.|      |
Mouse   446 EDQHDAYLERMKEEGKIREENANDSSDDSGEETDESFNPGEEEEDVAEEFDSNASASS------S 504

  Fly   510 GGGGDSDGAKKKKEKKSEKKEKKEKKHKEKERTKKPSKKKKDSGKPKRATTAFMLWLNDTRESIK 574
            ...||||..:||:|:....|..|::|.:.|   ...:||.||...|||..:|:|||||.:||.||
Mouse   505 SNEGDSDREEKKREQLKRAKMAKDRKSRRK---SSEAKKGKDPNAPKRPMSAYMLWLNASREKIK 566

  Fly   575 RENPGIKVTEIAKKGGEMWKEL--KDKSKWEDAAAKDKQRYHDEMRNYKPEAGGDSDNEKGGKSS 637
            .::|||.:|:::||.||:||.:  :.|.:|:..|...::.|...|:.|:   ||..|:.|..||.
Mouse   567 SDHPGISITDLSKKAGEIWKGMSKEKKEEWDRKAEDARREYEKAMKEYE---GGRGDSSKRDKSK 628

  Fly   638 KKRKTEPSPSKKANTS-GS-----------GFKSKEYISDDDSTSSDDEKDNEPAKKKSKPPSDG 690
            ||:|.:....||:..| ||           .|||||::|.|:|:|.:::
Mouse   629 KKKKVKAKMEKKSTPSRGSSSKSSSRQLSDSFKSKEFVSSDESSSGENK---------------- 677

  Fly   691 DAKKKKAKSE-------SEPEESEEDSNASDE 715
             :|||:.:||       |.|..||:.::.|||
Mouse   678 -SKKKRRRSEDSEEELASTPPSSEDSASGSDE 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssrp	NP_523830.2	POB3	20..499	CDD:227494	281/489 (57%)
		SSrecog	75..284	CDD:281523	139/208 (67%)
		PH2_SSRP1-like	332..427	CDD:270051	61/94 (65%)
		HMG_box	557..620	CDD:278906	26/64 (41%)
Ssrp1	NP_001129553.1	POB3	21..480	CDD:227494	267/468 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..708		100/278 (36%)
		HMG_box	547..614	CDD:366139	28/66 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2451
eggNOG	1	0.900	-	-		E1_COG5165
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H110735
Inparanoid	1	1.050	714	1.000	Inparanoid score	I635
Isobase	1	0.950	-	0	Normalized mean entropy	S1176
OMA	1	1.010	-	-		QHG54838
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003358
OrthoInspector	1	1.000	-	-		oto94860
orthoMCL	1	0.900	-	-		OOG6_101807
Panther	1	1.100	-	-	LDO	PTHR45849
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R946
SonicParanoid	1	1.000	-	-		X2245
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.810