Protein Alignment Ssrp and Hmgb1

DIOPT Version :10

• Sequence 1: NP_523830.2
• Gene: Ssrp / 37767
• FlyBaseID: FBgn0010278
• Length: 723
• Species: Drosophila melanogaster
• Sequence 2: NP_034569.1
• Gene: Hmgb1 / 15289
• MGIID: 96113
• Length: 215
• Species: Mus musculus
• Alignment Length: 212
• Identity: 65/212 - (30%)
• Similarity: 92/212 - (43%)
• Gaps: 63/212 - (29%)

  Fly   521 KKEKKSEKKEKKEKKHKEKE-RTKKP-----SKKKKDSGKPKRATTAFMLWLNDTRESIKRENPG 579
            |::.|.|...|.:|...|:| :|..|     .||.||...|||..:||.|:.::.|..||.|:||
Mouse    55 KEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPG 119

  Fly   580 IKVTEIAKKGGEMWKE--LKDKSKWEDAAAKDKQRYHDEMRNYKPEAGGDSDNEKGG----KSSK 638
            :.:.::|||.||||..  ..||..:|..|||.|::|..::..|:  |.|..|..|.|    :.||
Mouse   120 LSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYR--AKGKPDAAKKGVVKAEKSK 182

  Fly   639 KRKTEPSPSKKANTSGSGFKSKEYISDDDSTSSDDEKDNEPAKKKSKPPSDGDAKKKKAKSESEP 703
            |:|.|                           .|||:|                      .|.|.
Mouse   183 KKKEE---------------------------EDDEED----------------------EEDEE 198

  Fly   704 EESEEDSNASDEDEEDE 720
            ||.||:....:||::||
Mouse   199 EEEEEEDEDEEEDDDDE 215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ssrp	NP_523830.2	POB3	20..499	CDD:227494
		HMG-box_SSRP1-like	557..621	CDD:438810	25/65 (38%)
Hmgb1	NP_034569.1	Sufficient for interaction with HAVCR2. /evidence=ECO:0000269|PubMed:22842346	1..97		14/41 (34%)
		LPS binding (delipidated). /evidence=ECO:0000250|UniProtKB:P09429	3..15
		HMG-box_HMGB_rpt1	8..76	CDD:438794	7/20 (35%)
		NLS 1. /evidence=ECO:0000250|UniProtKB:P63159	27..43
		Nuclear localization signal (NLS) 1. /evidence=ECO:0000250|UniProtKB:P63159	27..43
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	76..95		6/18 (33%)
		LPS binding (Lipid A). /evidence=ECO:0000250|UniProtKB:P09429	80..96		5/15 (33%)
		Cytokine-stimulating activity. /evidence=ECO:0000250|UniProtKB:P09429	89..108		8/18 (44%)
		HMG-box_HMGB_rpt2	93..163	CDD:438795	27/69 (39%)
		Binding to AGER/RAGE. /evidence=ECO:0000250|UniProtKB:P63159	150..183		10/34 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..215		23/104 (22%)
		NLS 2. /evidence=ECO:0000250|UniProtKB:P63159	178..184		2/5 (40%)
		Nuclear localization signal (NLS) 2. /evidence=ECO:0000250|UniProtKB:P63159	178..184		2/5 (40%)