Protein Alignment CG5539 and REEP1

DIOPT Version :10

• Sequence 1: NP_611831.2
• Gene: CG5539 / 37766
• FlyBaseID: FBgn0034907
• Length: 296
• Species: Drosophila melanogaster
• Sequence 2: NP_001358208.1
• Gene: REEP1 / 65055
• HGNCID: 25786
• Length: 284
• Species: Homo sapiens
• Alignment Length: 290
• Identity: 70/290 - (24%)
• Similarity: 117/290 - (40%)
• Gaps: 59/290 - (20%)

  Fly     6 LVSQFLFFVYGTMGPAWQTYKTLNSGD-EEFLAWAKYWIVYAFLVTFEVLADVFLSWLPLYMPTK 69
            ::|:.:..::||:.||:.:||.:.|.| :|::.|..|||::|...|.|...|:||.|.|.|...|
Human     5 IISRLVVLIFGTLYPAYYSYKAVKSKDIKEYVKWMMYWIIFALFTTAETFTDIFLCWFPFYYELK 69

  Fly    70 LLLVVWIVLSAPAANVWIFDAILRPVLAKRQEEIDHFLHRGKEKLLIDALASMTQLVAQTQISVL 134
            :..|.|::......:..::...:.|.|:.:::|||..|.:.|:: ..|||....:.......:..
Human    70 IAFVAWLLSPYTKGSSLLYRKFVHPTLSSKEKEIDDCLVQAKDR-SYDALVHFGKRGLNVAATAA 133

  Fly   135 PFVSSFWSRSSTAPLRTSDLLQDST---GEGI----------GGRTSEDTDSANVSVQNLSSGSS 186
            ...:|....:.:..|| |..:||.|   |:|.          .||.|.......:|.....|.||
Human   134 VMAASKGQGALSERLR-SFSMQDLTTIRGDGAPAPSGPPPPGSGRASGKHGQPKMSRSASESASS 197

  Fly   187 PV-------------------GSLE----H-------LRDDSEELLVGVS---KATTHLQAEQFQ 218
            .|                   |.::    |       ..||.||.|:...   ||...::..
Human   198 SVCTCCSTCRTWKVVEGDVNEGGMKAWEPHQVQNPLAFSDDEEEDLLDFMYKYKAPRRMELP--- 259

  Fly   219 SDVSSESPRIINRRPQRKFKNAIAIASATK 248
               ....|||:..|    |:.....:|||:
Human   260 ---LEAPPRILRSR----FRKKSTSSSATE 282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5539	NP_611831.2	TB2_DP1_HVA22	20..94	CDD:460820	23/74 (31%)
REEP1	NP_001358208.1	TB2_DP1_HVA22	19..94	CDD:460820	23/74 (31%)