Protein Alignment sona and ADAMTS2

DIOPT Version :9

• Sequence 1: NP_001137746.1
• Gene: sona / 37762
• FlyBaseID: FBgn0034903
• Length: 1102
• Species: Drosophila melanogaster
• Sequence 2: NP_055059.2
• Gene: ADAMTS2 / 9509
• HGNCID: 218
• Length: 1211
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 142/562 - (25%)
• Similarity: 216/562 - (38%)
• Gaps: 149/562 - (26%)

  Fly   105 GNHLFAPEVSAIKSHNVSFSAFGQHLNLSLRATQGLFKGAPHQLRMW-----TVGSEPNATHGLD 164
            |:|||         :||  :.||:.|:|.||....|.  ||.....|     |...||.....|.
Human   106 GSHLF---------YNV--TVFGRDLHLRLRPNARLV--APGATMEWQGEKGTTRVEPLLGSCLY 157

  Fly   165 LQEIVHEQHTSNDVGEVFQDEKNMAAILMRRHMETGDLIMEGSIGHDLVIKPLPHELSPNPEESH 229
            :.::......|:    |.....:..|.|:|...|            :..|:||...|:....|..
Human   158 VGDVAGLAEASS----VALSNCDGLAGLIRMEEE------------EFFIEPLEKGLAAQEAEQG 206

  Fly   230 --HIIYKREASAAEGQLSDFAFMEPDDLLASEKLERLQRRQRRSRRSAPSSPDFEDLNDEDEGA- 291
              |::|:|                                       .|:||........|.||
Human   207 RVHVVYRR---------------------------------------PPTSPPLGGPQALDTGAS 232

  Fly   292 ---LDG--------EPQVAESRTRSRRQA---PYIIYPEVLVIVDYDGYRLHGGDNLQVKRYFIS 342
               ||.        |.....||.|:||.|   .|.|  |||:.||....:.||.:::|  :|.::
Human   233 LDSLDSLSRALGVLEEHANSSRRRARRHAADDDYNI--EVLLGVDDSVVQFHGKEHVQ--KYLLT 293

  Fly   343 FWNGV-DLRYRLLKGPRIRISIAGII-ISRGRDATPYLERNRVGRDAIDSAAALTDMGKYLFRER 405
            ..|.| ::.:....|..|.:.:..|| :|.|:.    :....:|    :.:.:|.::.::.:.::
Human   294 LMNIVNEIYHDESLGAHINVVLVRIILLSYGKS----MSLIEIG----NPSQSLENVCRWAYLQQ 350

  Fly   406 RLPV-----YDIAVAITKLDMCRRTSAYGECNRGTAGFAYVGGACVVNKRLEKVNSVAIIEDTGG 465
            :...     :|.|:.:|:.|       :|.  .|..|:|.|.|.|      ..|.|..:..: .|
Human   351 KPDTGHDEYHDHAIFLTRQD-------FGP--SGMQGYAPVTGMC------HPVRSCTLNHE-DG 399

  Fly   466 FSGIIVAAHEVGHLLGAVHDGSPPPSYLGGPGAQRCRWED--GYIMSDL-RHTERGFRWSACTVQ 527
            ||...|.|||.||:||..|||.          ..||..|.  |.||:.| :.....|.||.|:.|
Human   400 FSSAFVVAHETGHVLGMEHDGQ----------GNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQ 454

  Fly   528 SFHHFLNGDTATCLHNAP--HEDSALGRSLPGTLLSLDAQCRRDRG----TYACFKDERVCAQLF 586
            ....:|:  :..||.:.|  |:..||.: |||...|::.|||.|.|    ....|:....|.||:
Human   455 ELSRYLH--SYDCLLDDPFAHDWPALPQ-LPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLW 516

  Fly   587 CFDAQTGY-CVAYR-PAAEGSACGNGYHCLDGRCTPLPSNII 626
            |......| |...: |..:|:.|..|.||..|.|..|..:|:
Human   517 CSHPDNPYFCKTKKGPPLDGTMCAPGKHCFKGHCIWLTPDIL 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	61/238 (26%)
ADAMTS2	NP_055059.2	Pep_M12B_propep	100..211	CDD:279848	32/133 (24%)
		ZnMc_ADAMTS_like	266..467	CDD:239801	62/240 (26%)
		Reprolysin	268..470	CDD:279729	62/241 (26%)
		TSP1	564..616	CDD:214559
		Cell attachment site. /evidence=ECO:0000255	691..693
		Spacer	723..851
		ADAM_spacer1	723..837	CDD:283607
		TSP1	863..914	CDD:214559
		TSP1	917..976	CDD:214559
		TSP1	982..1029	CDD:214559
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1170..1191

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810