Protein Alignment sona and ADAMTS3

DIOPT Version :9

• Sequence 1: NP_001137746.1
• Gene: sona / 37762
• FlyBaseID: FBgn0034903
• Length: 1102
• Species: Drosophila melanogaster
• Sequence 2: NP_055058.2
• Gene: ADAMTS3 / 9508
• HGNCID: 219
• Length: 1205
• Species: Homo sapiens
• Alignment Length: 584
• Identity: 141/584 - (24%)
• Similarity: 216/584 - (36%)
• Gaps: 152/584 - (26%)

  Fly    87 LSKNAYYSELKHEA--LASGGNHLFAPEVSAIKSHNVSFSAFGQHLNLSLRATQGLFKGAPHQLR 149
            ||.....|..|..|  ::|....||           .:.:|||:..:|.|:....|.  ||..:.
Human    57 LSHTLSASHKKRSARDVSSNPEQLF-----------FNITAFGKDFHLRLKPNTQLV--APGAVV 108

  Fly   150 MWTVGSEPNATHGLDLQEIVHEQHTS----NDVGEVFQDEKNMAAILMRR--HMET-----GDLI 203
            .|                  ||  ||    |....:...:...|...:||  .::|     ||::
Human   109 EW------------------HE--TSLVPGNITDPINNHQPGSATYRIRRTEPLQTNCAYVGDIV 153

  Fly   204 --------------MEGSIGHD---LVIKPLPHELSPNPEESH-HIIYKREA--SAAEGQLSDFA 248
                          :.|.|..|   ..|:||........|:.. |::|||.|  .|......||.
Human   154 DIPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMEEEKGRIHVVYKRSAVEQAPIDMSKDFH 218

  Fly   249 FMEPDDLLASEKLERLQRRQRRSRRSAPSSPDFEDLNDEDEGALDG--EPQVAESRTRSRRQAPY 311
            :.|.|       ||.|                      :|.|.:.|  ..|:.|:..|.|.....
Human   219 YRESD-------LEGL----------------------DDLGTVYGNIHQQLNETMRRRRHAGEN 254

  Fly   312 IIYPEVLVIVDYDGYRLHGGDNLQVKRYFISFWNGV-DLRYRLLKGPRIRISIAGIIISRGRDAT 375
            ....|||:.||....|.||.:::|  .|.::..|.| ::.:....|..|.:.:..:|:.....:.
Human   255 DYNIEVLLGVDDSVVRFHGKEHVQ--NYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSI 317

  Fly   376 PYLERNRVGRDAIDSAAALTDMGKYLFRERRLPV-----YDIAVAITKLDMCRRTSAYGECNRGT 435
            ..:||....|       :|.::.::..:::|..:     :|.|:.:|:.|       :|..  |.
Human   318 SLIERGNPSR-------SLENVCRWASQQQRSDLNHSEHHDHAIFLTRQD-------FGPA--GM 366

  Fly   436 AGFAYVGGACVVNKRLEKVNSVAIIEDTGGFSGIIVAAHEVGHLLGAVHDGSPPPSYLGGPGAQR 500
            .|:|.|.|.|      ..|.|..:..: .|||...|.|||.||:||..|||.          ..|
Human   367 QGYAPVTGMC------HPVRSCTLNHE-DGFSSAFVVAHETGHVLGMEHDGQ----------GNR 414

  Fly   501 CRWED--GYIMSDL-RHTERGFRWSACTVQSFHHFLNGDTATCLHNAP--HEDSALGRSLPGTLL 560
            |..|.  |.:|:.| :.....:.||.|:.|....:::  :..||.:.|  |:...| ..|||...
Human   415 CGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIH--SYDCLLDDPFDHDWPKL-PELPGINY 476

  Fly   561 SLDAQCRRDRGT----YACFKDERVCAQLFCFDAQTGY-CVAYR-PAAEGSACGNGYHCLDGRC 618
            |:|.|||.|.|.    ...|:....|.||:|......| |...: |..:|:.|..|..|..|.|
Human   477 SMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHC 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	58/237 (24%)
ADAMTS3	NP_055058.2	Pep_M12B_propep	66..200	CDD:279848	33/166 (20%)
		ZnMc_ADAMTS_like	256..457	CDD:239801	58/237 (24%)
		Reprolysin	258..460	CDD:279729	59/238 (25%)
		TSP1	554..605	CDD:214559
		Spacer	713..844
		ADAM_spacer1	713..827	CDD:283607
		TSP1	848..904	CDD:214559
		TSP1	912..967	CDD:214559
		TSP1	970..1015	CDD:214559
		PLAC	1023..1051	CDD:285849
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1174..1205

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810