Protein Alignment sona and ADAMTS4

DIOPT Version :9

• Sequence 1: NP_001137746.1
• Gene: sona / 37762
• FlyBaseID: FBgn0034903
• Length: 1102
• Species: Drosophila melanogaster
• Sequence 2: NP_001307265.1
• Gene: ADAMTS4 / 9507
• HGNCID: 220
• Length: 846
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 122/522 - (23%)
• Similarity: 195/522 - (37%)
• Gaps: 130/522 - (24%)

  Fly   125 AFGQHLNLSLRATQGLFKGAPHQLRMWTV---GSEPNATHGLDLQEIVHEQHTSNDVGEVFQDEK 186
            |||:.|.|.|....|:      |:...||   |..|....|.:....:        .|.:..|.:
Human    87 AFGETLLLELEQDSGV------QVEGLTVQYLGQAPELLGGAEPGTYL--------TGTINGDPE 137

  Fly   187 NMAAILMRRHMETGDLIMEGSI---GHDLVIKPLPHELSPNPE--ESHHIIYKREASAAEGQLSD 246
            ::|::    |.:.|.|:  |.:   |.:|.::||... :||..  ...||:.::..::.:|.:.:
Human   138 SVASL----HWDGGALL--GVLQYRGAELHLQPLEGG-TPNSAGGPGAHILRRKSPASGQGPMCN 195

  Fly   247 FAFMEPDDLLASEKLERLQRRQRRSRRSAPSSPDFEDLNDEDEGALDGEPQVAESRTRSRRQAPY 311
                      ....|.....|.||::|.|..|.
Human   196 ----------VKAPLGSPSPRPRRAKRFASLSR-------------------------------- 218

  Fly   312 IIYPEVLVIVDYDGYRLHGGDNLQVKRYFISFWNGVDLRYRLLKGPRIR--ISIAG---IIISRG 371
              :.|.||:.|......||..   :|||.::.   :....:..|.|.||  :|:..   :|:..|
Human   219 --FVETLVVADDKMAAFHGAG---LKRYLLTV---MAAAAKAFKHPSIRNPVSLVVTRLVILGSG 275

  Fly   372 RDATPYLERNRVGRDAIDSAAALTDMGKYLFRERRLPV--------YDIAVAITKLDMCRRTSAY 428
            .      |..:||..|..:      :..:...:|.|..        :|.|:..|:.|:|
Human   276 E------EGPQVGPSAAQT------LRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLC------ 322

  Fly   429 GECNRGTAGFAYVGGACVVNKRLEKVNSVAIIEDTGGFSGIIVAAHEVGHLLGAVHDGSPPPSYL 493
            |.....|.|.|.||..|      :...|.||:|| .|......||||:||:...:||.|.|...|
Human   323 GVSTCDTLGMADVGTVC------DPARSCAIVED-DGLQSAFTAAHELGHVFNMLHDNSKPCISL 380

  Fly   494 GGP-GAQRCRWEDGYIMSD-LRHTERGFRWSACTVQSFHHFLNGDTATCLHNAPHEDSALGRSLP 556
            .|| ...|      ::|:. :.|.:....||.|:.:....||:.....||.:.|.....|..:.|
Human   381 NGPLSTSR------HVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTFP 439

  Fly   557 GTLLSLDAQCRRDRG--TYACFKDERVCAQLFCFDAQTGYCVA---YRPAAEGSACGNGYHCLDG 616
            |.....|.||:...|  :..|.:....||.|:|.....|:.:.   :.|.|:|:.||....|:.|
Human   440 GKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGG 504

  Fly   617 RC 618
            ||
Human   505 RC 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	62/243 (26%)
ADAMTS4	NP_001307265.1	Pep_M12B_propep	70..181	CDD:279848	27/114 (24%)
		Cysteine switch. /evidence=ECO:0000250	192..199		0/16 (0%)
		Reprolysin	218..428	CDD:279729	63/280 (23%)
		ZnMc_ADAMTS_like	218..425	CDD:239801	62/277 (22%)
		ADAM_CR	438..509	CDD:301627	21/69 (30%)
		ADAM_CR	490..659	CDD:301627	8/17 (47%)
		TSP1	531..575	CDD:214559

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810