DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sona and ADAMTSL1

DIOPT Version :9

Sequence 1:	NP_001137746.1	Gene:	sona / 37762	FlyBaseID:	FBgn0034903	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	XP_011516365.1	Gene:	ADAMTSL1 / 92949	HGNCID:	14632	Length:	1828	Species:	Homo sapiens

Alignment Length:	658	Identity:	123/658 - (18%)
Similarity:	206/658 - (31%)	Gaps:	180/658 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 SIGKGPKVNAALPPHHVKKDLSKNAYYSELKH-EALASGGNHLFAPEVSAIKSHNVSFSAFGQHL 130
            ::.:.|:....|...|:...|::..:.|.|:| :.|........:|...:...|   .|.|...|
Human  1150 NLSQQPEELRDLYSKHLVAQLAQEIFRSHLEHQDTLLKPSERRTSPVTLSPHKH---VSGFSSSL 1211

  Fly   131 NLSLRATQGLFKGAPHQLRMWTVGSEPNATHGLDLQEIVHEQHTSNDVGEVFQDEKNMAAILMRR 195
            ..|.....|.....||  |..|:..:.:|...|...|:|      ..:|:.........::|:
Human  1212 RTSSTGDAGGGSRRPH--RKPTILRKISAAQQLSASEVV------THLGQTVALASGTLSVLL-- 1266

  Fly   196 HMETGDLIMEGSIGHDLVIKPLPHELSPNPEESHHIIYKREASAAEGQLSDFAFMEPDDLLASEK 260
            |.|        :|||            |.|.    |.:.|  :..|.|.||...::|||.|
Human  1267 HCE--------AIGH------------PRPT----ISWAR--NGEEVQFSDRILLQPDDSL---- 1301

  Fly   261 LERLQRRQRRSRRSAPSSPD--FEDLNDEDEGALD---------GEPQVAESR-TRSRRQAPYII 313
                       :..||...|  |...|..:....|         |:|.|..|| |....:.|
Human  1302 -----------QILAPVEADVGFYTCNATNALGYDSVSIAVTLAGKPLVKTSRMTVINTEKP--- 1352

  Fly   314 YPEVLVIVDYDGYRLHGGDNLQVKRYFISFWNGVDLRYRLLKGPRIRISIAGIIISRGRDATPYL 378
                .|.||.       |..::..:       ||::        .|...:||:   ...:.|.:.
Human  1353 ----AVTVDI-------GSTIKTVQ-------GVNV--------TINCQVAGV---PEAEVTWFR 1388

  Fly   379 ERNRVGRDAIDSAAALTDMGKYLFRERRLPVYDIAVAITKLDMCRRTSAYGECNRGTAGFAYVGG 443
            .::::|             ..:...|..|.:.:::.:...|..||..:.:||....|.  ..:..
Human  1389 NKSKLG-------------SPHHLHEGSLLLTNVSSSDQGLYSCRAANLHGELTESTQ--LLILD 1438

  Fly   444 ACVVNKRLEKVNSVAIIEDTG-----------GFSGIIVAAHEVGHLLGAVHDGSPPPSYLGGPG 497
            ...|..:||.:.  |::..||           |...::...:..  |||....|.|.|:.....|
Human  1439 PPQVPTQLEDIR--ALLAATGPNLPSVLTSPLGTQLVLDPGNSA--LLGCPIKGHPVPNITWFHG 1499

  Fly   498 AQRCRWEDGYIMSDLRHTERGFRWSACTVQSFHHFLNG----DTATCLHNAPHEDSALGRSLPGT 558
            .|......|..                     ||.|..    ..|.....:..|.|.|.::..|.
Human  1500 GQPIVTATGLT---------------------HHILAAGQILQVANLSGGSQGEFSCLAQNEAGV 1543

  Fly   559 LL------------SLD--AQCRRDRGTYACFKDERVCAQLFCFDAQTGYCVA-YRPAAEGSACG 608
            |:            |:|  |.|....|... .:..|:...|...:....:|.. .|||.:..||
Human  1544 LMQKASLVIQDYWWSVDRLATCSASCGNRG-VQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIAC- 1606

  Fly   609 NGYHCLDGRCTPLPSN-IIPDYGHNYRLVYNKIDNKKDAAEDVESSSEETESQEDETESVEDQDE 672
            |...|        ||. ::..:....|.....:..::...:.:::|...|....|....|..:..
Human  1607 NRRDC--------PSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPV 1663

  Fly   673 GTTSSEEQ 680
            .|.:..:|
Human  1664 DTQACNQQ 1671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	39/243 (16%)
ADAMTSL1	XP_011516365.1	TSP1	102..148	CDD:214559
		TSP1	446..504	CDD:214559
		TSP1	510..>539	CDD:214559
		TSP1	597..650	CDD:214559
		TSP1	736..795	CDD:214559
		TSP_1	801..854	CDD:278517
		TSP1	856..915	CDD:214559
		IGc2	957..1015	CDD:197706
		Ig	1263..1323	CDD:299845	23/102 (23%)
		IG_like	1352..1436	CDD:214653	20/130 (15%)
		IGc2	1366..1426	CDD:197706	12/90 (13%)
		I-set	1461..1552	CDD:254352	19/113 (17%)
		IGc2	1476..1542	CDD:197706	16/88 (18%)
		TSP1	1618..1673	CDD:214559	7/54 (13%)
		PLAC	1796..1825	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810