DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sona and PAPLN

DIOPT Version :9

Sequence 1:	NP_001137746.1	Gene:	sona / 37762	FlyBaseID:	FBgn0034903	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	NP_001352835.1	Gene:	PAPLN / 89932	HGNCID:	19262	Length:	1278	Species:	Homo sapiens

Alignment Length:	651	Identity:	113/651 - (17%)
Similarity:	188/651 - (28%)	Gaps:	177/651 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   484 HDGSPPPSYLGGPGAQRCRWEDGYIMSDLRHTERGFRWSACTVQSFHHFLNGDT----------A 538
            |..|..|.:.|.|||. |:........|......|...:.|| :|:    .||:          |
Human   642 HTASLGPQWQGCPGAP-CQQSRYGCCPDRVSVAEGPHHAGCT-KSY----GGDSTGGMPRSRAVA 700

  Fly   539 TCLHNAPHEDSALGRSLPGTLLSLDAQCRRDRGTYACFKDERVCAQLFCFDAQTGYCVAYRPAAE 603
            :.:||. |:        |....:..::||..:  :.|           |:|   ....|..|..|
Human   701 STVHNT-HQ--------PQAQQNEPSECRGSQ--FGC-----------CYD---NVATAAGPLGE 740

  Fly   604 GSACGNGYHCLDGRCTPLPS------------NIIPDYGHNYRLVY-------NKIDNKKDAAED 649
            | ..|...|....||. |||            ..:...|...|..|       |...::::....
Human   741 G-CVGQPSHAYPVRCL-LPSAHGSCADWAARWYFVASVGQCNRFWYGGCHGNANNFASEQECMSS 803

  Fly   650 VESSSEETESQEDETESVEDQDEGTTSSEEQEDNKIEQSSAAGGAAAQSTTTARSTTTTTVRTTS 714
            .:.|.......:..........:|..||...|.   |.|....|||.|..........   |...
Human   804 CQGSLHGPRRPQPGASGRSTHTDGGGSSPAGEQ---EPSQHRTGAAVQRKPWPSGGLW---RQDQ 862

  Fly   715 TTTTTAKPKSKSFGYLHRSLPERQWMQDNG-------------------------------VLVT 748
            .......|.:::||       |..|.|:.|                               .||.
Human   863 QPGPGEAPHTQAFG-------EWPWGQELGSRAPGLGGDAGSPAPPFHSSSYRISLAGVEPSLVQ 920

  Fly   749 TRISSSVSSSSSGSSSGEAAATSTR--RPTTTTTTQTPNLFQIYTHELRKQIEYYLHMLQTQQHA 811
            ..:...|..|.|..::.|:.|...:  :|.::.           .|.|:......:|.||.:...
Human   921 AALGQLVRLSCSDDTAPESQAAWQKDGQPISSD-----------RHRLQFDGSLIIHPLQAEDAG 974

  Fly   812 T----KFQPEQQQQQSQ-----------QQQSIVEIPLVQKSLTNYSVTSSSSSTSNGAKQQP-P 860
            |    ..:|.:..|:.|           .:..:...|..:....::....::..........| |
Human   975 TYSCGSTRPGRDSQKIQLRIIGGDMAVLSEAELSRFPQPRDPAQDFGQAGAAGPLGAIPSSHPQP 1039

  Fly   861 SNK---DENQRQQQQQQQAQQQLQDGLPDEENEATAGIQSNEAIERQKRKFPTTPTAATSAAQKS 922
            :|:   |:|          |.::.|..|.:....|...:.          ||..........|..
Human  1040 ANRLRLDQN----------QPRVVDASPGQRIRMTCRAEG----------FPPPAIEWQRDGQPV 1084

  Fly   923 ATP---ATPATSATSARPTPTTAKPITTSSF----LDAYFKKLQALHDAGSASSSTTTTTTTS-- 978
            ::|   ..|..|...:|.........|..:|    .|..:.:|:.|.:...:....|.|....
Human  1085 SSPRHQLQPDGSLVISRVAVEDGGFYTCVAFNGQDRDQRWVQLRVLGELTISGLPPTVTVPEGDT 1149

  Fly   979 ------VSSSVSSATSSKQQHPQQQQQQQVQQIADGSHFLKRTPHRS----SLKAYKTSSSSSNN 1033
                  |:....:...|:...|.|....:|.|..||:..:.....|.    :..||:.|.:.|.:
Human  1150 ARLLCVVAGESVNIRWSRNGLPVQADGHRVHQSPDGTLLIYNLRARDEGSYTCSAYQGSQAVSRS 1214

  Fly  1034 S 1034
            :
Human  1215 T 1215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	16/67 (24%)
PAPLN	NP_001352835.1	TSP1	29..80	CDD:214559
		ADAM_spacer1	183..298	CDD:310520
		TSP1	308..361	CDD:214559
		TSP1	369..424	CDD:214559
		TSP1	424..481	CDD:214559
		TSP1	488..539	CDD:214559
		Kunitz_BPTI	753..805	CDD:278443	9/52 (17%)
		Papilin_u7	814..905	CDD:318767	18/103 (17%)
		Ig	914..>978	CDD:325142	14/74 (19%)
		I-set	1049..1119	CDD:254352	13/79 (16%)
		IG	1139..1219	CDD:214652	15/77 (19%)
		PLAC	1235..1267	CDD:312271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810