Protein Alignment sona and ADAM7

DIOPT Version :10

• Sequence 1: NP_001137746.1
• Gene: sona / 37762
• FlyBaseID: FBgn0034903
• Length: 1102
• Species: Drosophila melanogaster
• Sequence 2: NP_003808.2
• Gene: ADAM7 / 8756
• HGNCID: 214
• Length: 754
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 98/528 - (18%)
• Similarity: 168/528 - (31%)
• Gaps: 195/528 - (36%)

  Fly   160 THGLDL-----QEIVHE----------------QHTSNDVGEVFQDEKNMAAILMRRHMETGD-L 202
            ||..|:     :|:::|                :...::..|.|...|..|   ..||.:..| .
Human    46 THDDDILKTYEEELLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEA---FTRHPQIMDHC 107

  Fly   203 IMEGSIGHD-----------------------LVIKPLPHELSPNPEESHHIIYK---REASAAE 241
            ..:|||.|:                       .:|:|:.:.     :|..|:::|   |....|.
Human   108 FYQGSIVHEYDSAASISTCNGLRGFFRINDQRYLIEPVKYS-----DEGEHLVFKYNLRVPYGAN 167

  Fly   242 GQLSDFAFMEPDDLLASEKLERLQRRQRRSRRSAPSSPDFEDLNDEDEGALDGEPQVAESRTRSR 306
            ...::..|                     :|::.|..      |:.:|          :|:.:..
Human   168 YSCTELNF---------------------TRKTVPGD------NESEE----------DSKIKGI 195

  Fly   307 RQAPYIIYPEVLVIVDYDGYRLHGGDNLQVKRYFISFWNGVDLRYRLLKGPRIRISIAGIIISRG 371
            ....|:   |:.::.|...||.:|..:.:::.......|.|::.|:.|   .|.:::.||.|...
Human   196 HDEKYV---ELFIVADDTVYRRNGHPHNKLRNRIWGMVNFVNMIYKTL---NIHVTLVGIEIWTH 254

  Fly   372 RDATP--------------YLERNRVGRDAIDSAAALTDMGKYLFRERRLPVYDIAVAITKLDMC 422
            .|...              :.|:....|...|....|:  ||:|:..
Human   255 EDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLLS--GKWLYSH------------------ 299

  Fly   423 RRTSAYGECNRGTAGFAYVGGACVVNKRLEKVNSVAIIEDTGGFSGIIV--AAHEVGHLLGAVHD 485
                        ..|.:|.||.|:      ...|.:||:|....:.||.  .||::||.||..||
Human   300 ------------VQGISYPGGMCL------PYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHD 346

  Fly   486 GSPPPSYLGGPGAQRCRWEDGYIMSDLRHTERGFRWSACTVQSFHHFLNGDTATCLHNAP----- 545
            ..|            |....|..:.|...:....::|.|:...:|.:|.....||:.|.|
Human   347 EFP------------CTCPSGKCVMDSDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNF 399

  Fly   546 HEDSALGRSLPGTLLSLDAQCRRDRGTYACFKDERVCAQLFCFDAQTGYCVAYRPAAEGSACGNG 610
            |:....|..            :.|.|........:.|... |.||.|  || .:|         |
Human   400 HDFQFCGNK------------KLDEGEECDCGPAQECTNP-CCDAHT--CV-LKP---------G 439

  Fly   611 YHCLDGRC 618
            :.|.:|.|
Human   440 FTCAEGEC 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	50/244 (20%)
		ADAMTS_CR_2	556..619	CDD:465496	14/63 (22%)
ADAM7	NP_003808.2	Pep_M12B_propep	28..153	CDD:460254	19/114 (17%)
		Reprolysin	199..394	CDD:426256	52/250 (21%)
		DISIN	411..485	CDD:214490	14/50 (28%)
		ACR	488..624	CDD:214743