Protein Alignment sona and ADAM20

DIOPT Version :10

• Sequence 1: NP_001137746.1
• Gene: sona / 37762
• FlyBaseID: FBgn0034903
• Length: 1102
• Species: Drosophila melanogaster
• Sequence 2: XP_005268208.1
• Gene: ADAM20 / 8748
• HGNCID: 199
• Length: 776
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 109/536 - (20%)
• Similarity: 166/536 - (30%)
• Gaps: 205/536 - (38%)

  Fly   206 GSIG----HDLVIKPLPHELSPNPEESHHIIYKREASAAEGQLSDFAFMEPDDL--------LAS 258
            |.:|    :|||.:..|..:|...|   |::||               ::.||.        |..
Human   181 GFLGMLQINDLVYEIKPISVSATFE---HLVYK---------------IDSDDTQFPPMRCGLTE 227

  Fly   259 EKLERLQRRQRRSRRSAPSSPDFEDLNDEDEGALDGEPQVAESRTRSRRQAPYI------IYPEV 317
            ||:                             |...|.|::.:.|  .:|:.::      .:.|:
Human   228 EKI-----------------------------AHQMELQLSYNFT--LKQSSFVGWWTHQRFVEL 261

  Fly   318 LVIVDYDGYRLHGGDNLQVKRYFISFWNGVDLRYRLLKGPRIRISIAGIIISRGRDATPYLERNR 382
            :|:||...|.....:...|:....:..|.||..|..|:   :.:.:.||.|....:..|
Human   262 VVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYHPLE---VDVILTGIDIWTASNPLP------ 317

  Fly   383 VGRDAIDSAAALTDMGKYLFRERRLPVYDIAVAITKLDMCRRTSAYGECNRGTAGFAYVGGACVV 447
            ...| :|:......:.|......||. :|:|....|           :......|.|||.|.|
Human   318 TSGD-LDNVLEDFSIWKNYNLNNRLQ-HDVAHLFIK-----------DTQGMKLGVAYVKGIC-- 367

  Fly   448 NKRLEKVNS-VAIIEDTGGFSGIIVAAHEVGHLLGAVHDGSPPPSYLGGPGAQRCRWEDGYIMSD 511
               ....|: |.:.||.......|...||:||.||..||
Human   368 ---QNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHD-------------------------- 403

  Fly   512 LRHTERGFRWSACTVQ--SFHHFLNGDT--ATCLHNAPHEDSALGRSL-------PGTLLSL--- 562
                   .:|..|.:|  ..|.:....|  :.|.: |.:.||.:...|       ||.:..|
Human   404 -------TQWCVCELQWCIMHAYRKVTTKFSNCSY-AQYWDSTISSGLCIQPPPYPGNIFRLKYC 460

  Fly   563 -------DAQCRRDRGTY-ACFKDERVCAQLFCFDAQTGYCVAYRPAAEGSACGNGYHCLDGRCT 619
                   ..:|  |.||. .|.||.  |..|.|         ...|   |:||..|..|.|  |.
Human   461 GNLVVEEGEEC--DCGTIRQCAKDP--CCLLNC---------TLHP---GAACAFGICCKD--CK 507

  Fly   620 PLPSNI----------IPDY--GHNYR-----------------LVYNKIDNKKDA------AED 649
            .|||..          :|::  |.:::                 ..|.|..|..|.      .:|
Human   508 FLPSGTLCRQQVGECDLPEWCNGTSHQCPDDVYVQDGISCNVNAFCYEKTCNNHDIQCKEIFGQD 572

  Fly   650 VESSSEETESQEDETE 665
            ..|:|:.. .||..|:
Human   573 ARSASQSC-YQEINTQ 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	48/233 (21%)
		ADAMTS_CR_2	556..619	CDD:465496	20/73 (27%)
ADAM20	XP_005268208.1	Pep_M12B_propep	91..209	CDD:460254	9/30 (30%)
		ZnMc_adamalysin_II_like	257..446	CDD:239797	52/249 (21%)
		Disintegrin	466..538	CDD:459709	23/89 (26%)
		ACR	542..678	CDD:214743	10/47 (21%)