Protein Alignment sona and ADAM19

DIOPT Version :10

• Sequence 1: NP_001137746.1
• Gene: sona / 37762
• FlyBaseID: FBgn0034903
• Length: 1102
• Species: Drosophila melanogaster
• Sequence 2: XP_047273814.1
• Gene: ADAM19 / 8728
• HGNCID: 197
• Length: 955
• Species: Homo sapiens
• Alignment Length: 666
• Identity: 138/666 - (20%)
• Similarity: 213/666 - (31%)
• Gaps: 247/666 - (37%)

  Fly    95 ELKHEALASGGNHLFAP--EVSAIKSHNVSFSAFGQHLNLSLRATQGLFKGAPHQLRMWTVGSEP 157
            :|:||.:........:|  |...:|: .:...|.|:.|.|.|...:.||..:..:....:.|:..
Human    40 KLQHELIIPQWKTSESPVREKHPLKA-ELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQ 103

  Fly   158 NATHGLDLQEIVHEQHTSNDVGEVFQDEKNMAAILMRRHMETGDLIMEGSIGHDLVIKPLPHELS 222
            ..|..|:.....|        |.|.:.|.:...:...|.:. |.:.:..::.:  ||:|||
Human   104 TTTRKLEDHCFYH--------GTVRETELSSVTLSTCRGIR-GLITVSSNLSY--VIEPLP---- 153

  Fly   223 PNPEESHHIIYKREASAAEGQLSDFAFMEPDDL-LASEKLERLQRRQRRSRRSAPSSPDFEDLND 286
              ..:..|:||:.|..........|...:|... .|.:..::.::|.||.:|        ||||.
Human   154 --DSKGQHLIYRSEHLKPPPGNCGFEHSKPTTRDWALQFTQQTKKRPRRMKR--------EDLNS 208

  Fly   287 EDEGALDGEPQVAESRTRSRRQAPYIIYPEVLVIVDYDGYRLHGGDNLQVKRYFISFWNGVDLRY 351
                                     :.|.|:.::.||..::.:..|....|...|...|.||..|
Human   209 -------------------------MKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDKFY 248

  Fly   352 RLLKGPRIRISIAGI-IISRGR----DATPYLERNRVGRDAIDSAAALTDMGKYLFRERRL---P 408
            |.|   .|||::.|: :.:.|.    ...||                 :.:..:|...|:|   .
Human   249 RSL---NIRIALVGLEVWTHGNMCEVSENPY-----------------STLWSFLSWRRKLLAQK 293

  Fly   409 VYDIAVAITKLDMCRRTSAYGECNRGTAGFAYVGGACVVNKRLEKVNSVAIIEDTGGFS------ 467
            .:|.|..||.:      |.:|.    |.|.|.:...|.|.:             :||.:
Human   294 YHDNAQLITGM------SFHGT----TIGLAPLMAMCSVYQ-------------SGGVNMDHSEN 335

  Fly   468 --GIIVA-AHEVGHLLGAVHD--------------------GSPPPSYLGG-------------- 495
              |:... |||:||..|..||                    |.|.|....|
Human   336 AIGVAATMAHEMGHNFGMTHDSADCCSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGG 400

  Fly   496 -------P------GAQRCRWEDGYIMSDLRHTERG---------FRWSACTVQSFHHFLNGDTA 538
                   |      |.:||  .:|| :.|....:.|         ...|.||::        ..|
Human   401 GMCLSNMPDTRMLYGGRRC--GNGY-LEDGEECDCGEEEECNNPCCNASNCTLR--------PGA 454

  Fly   539 TCLH-NAPHEDSALGRSLPGTLLSLDA-QCRRDRGTYACFK-----------DERVC--AQLFCF 588
            .|.| :..|:...|.   ||||....| ||  |...:...|           |...|  .|.:|:
Human   455 ECAHGSCCHQCKLLA---PGTLCREQARQC--DLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCY 514

  Fly   589 DAQTGYCVAY------------RPAAE-------------GSACG---NGYH------------- 612
            :   |.|:.|            |||.:             |: ||   ||.|
Human   515 N---GMCLTYQEQCQQLWGPGARPAPDLCFEKVNVAGDTFGN-CGKDMNGEHRKCNMRDAKCGKI 575

  Fly   613 -CLDGRCTPLPSNIIP 627
             |......||.||.:|
Human   576 QCQSSEARPLESNAVP 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	62/301 (21%)
		ADAMTS_CR_2	556..619	CDD:465496	26/118 (22%)
ADAM19	XP_047273814.1	Pep_M12B_propep	44..162	CDD:460254	26/135 (19%)
		Reprolysin	210..408	CDD:426256	49/240 (20%)
		DISIN	439..499	CDD:214490	17/72 (24%)
		ACR	501..646	CDD:214743	22/95 (23%)