Protein Alignment sona and ADAMTS12

DIOPT Version :9

• Sequence 1: NP_001137746.1
• Gene: sona / 37762
• FlyBaseID: FBgn0034903
• Length: 1102
• Species: Drosophila melanogaster
• Sequence 2: XP_016865394.1
• Gene: ADAMTS12 / 81792
• HGNCID: 14605
• Length: 1631
• Species: Homo sapiens
• Alignment Length: 656
• Identity: 147/656 - (22%)
• Similarity: 239/656 - (36%)
• Gaps: 201/656 - (30%)

  Fly    20 QGLPDLHKQMTPEQLQSVFHVDTHDAVPHYELVQLQHHENNHNRRRRSIGKGPKVNAALPPHHVK 84
            :|||:.| .:.|.::         ||..|:....| |:....:||:|.:
Human    47 KGLPEYH-VVGPVRV---------DASGHFLSYGL-HYPITSSRRKRDL---------------- 84

  Fly    85 KDLSKNAYYSELKHEALASGGNHLFAPEVSAIKSHNVSFSAFGQHLNLSLRATQGLFKGAPHQLR 149
             |.|::..|..:.||.                           :.|..:|...||....:
Human    85 -DGSEDWVYYRISHEE---------------------------KDLFFNLTVNQGFLSNS----- 116

  Fly   150 MWTVGSEPNATHGLDLQEIVHEQHTSNDVGEVFQDEKNMAAILMRRHMETGDLIMEGS-IG---- 209
                              .:.|:...|     ....|.||:.....|: :|.::.:|: :|
Human   117 ------------------YIMEKRYGN-----LSHVKMMASSAPLCHL-SGTVLQQGTRVGTAAL 157

  Fly   210 ---HDLV-IKPLPH-ELSPNPEESH---------HIIYKREASAAEGQLSDFAFMEP-----DDL 255
               |.|. ...||| :....|.:.|         ||:|:|: ...|.:       ||     |.:
Human   158 SACHGLTGFFQLPHGDFFIEPVKKHPLVEGGYHPHIVYRRQ-KVPETK-------EPTCGLKDSV 214

  Fly   256 LASEKLERLQRRQRRSRRSAPSSPDFEDLNDEDEGALDGEPQVAESRTRSRRQAPYIIYPEVLVI 320
            ..|:|.|..  |::..|.:.|                        ||:.|||......:.|.||:
Human   215 NISQKQELW--REKWERHNLP------------------------SRSLSRRSISKERWVETLVV 253

  Fly   321 VDYDGYRLHGGDNLQVKRYFISFWNGV-DLRYRLLKGPRIRISIAGIIISRGRDATPYLERNRVG 384
            .|......||.:|  |:.|.::..|.| .|.:....|..|.|.:..:|:         ||....|
Human   254 ADTKMIEYHGSEN--VESYILTIMNMVTGLFHNPSIGNAIHIVVVRLIL---------LEEEEQG 307

  Fly   385 RDAIDSA-AALTDMGKYLFRERRL-------PV-YDIAVAITKLDMCRRTSAYGECNRGTAGFAY 440
            ...:..| ..|:...|:   ::.:       || :|:||.:|:.|:|...:...|    |.|.::
Human   308 LKIVHHAEKTLSSFCKW---QKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCE----TLGLSH 365

  Fly   441 VGGACVVNKRLEKVNSVAIIEDTGGFSGIIVA---AHEVGHLLGAVHDGSPPPSYLGGPGAQRCR 502
            :.|.|..::      |..|.||    ||:.:|   |||:||..|..|||........|
Human   366 LSGMCQPHR------SCNINED----SGLPLAFTIAHELGHSFGIQHDGKENDCEPVG------- 413

  Fly   503 WEDGYIMS-DLRHTERGFRWSACTVQSFHHFLNGDTATCLHNAPHEDSALGRSL-PGTLLSLDAQ 565
             ...|||| .|::......||.|:.:....||:.....||.:.|.:.....:.: ||.:..:..|
Human   414 -RHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQ 477

  Fly   566 CRRDRGTYA--CFKDERVCAQLFCFDAQTGYCVA-YRPAAEGSACGNGYHCLDGRCTPL---PSN 624
            |:...|..|  |.:.|.||..|:|  :..|:|.: ...||:|:.||....|:.|:|..:   |.:
Human   478 CQLQYGPNATFCQEVENVCQTLWC--SVKGFCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPES 540

  Fly   625 IIPDYG 630
            |...:|
Human   541 IPGGWG 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	63/242 (26%)
ADAMTS12	XP_016865394.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810