Protein Alignment sona and ADAM33

DIOPT Version :10

• Sequence 1: NP_001137746.1
• Gene: sona / 37762
• FlyBaseID: FBgn0034903
• Length: 1102
• Species: Drosophila melanogaster
• Sequence 2: XP_005260900.1
• Gene: ADAM33 / 80332
• HGNCID: 15478
• Length: 826
• Species: Homo sapiens
• Alignment Length: 581
• Identity: 135/581 - (23%)
• Similarity: 196/581 - (33%)
• Gaps: 174/581 - (29%)

  Fly   138 QGLFKG---APHQLRMWTVGSEPNATHGLDLQEIVHEQHTSNDVGEV----------FQDEKNMA 189
            ||...|   .||    |.:..:|..|..|:      |..:..|:|.|          .:.||| .
Human    32 QGHIPGQPVTPH----WVLDGQPWRTVSLE------EPVSKPDMGLVALEAEGQELLLELEKN-H 85

  Fly   190 AILMRRHMETGDLIMEGSIGHDLVIKP-----LPHELSPNPEESH-HIIYKREASAAEGQLSDFA 248
            .:|...::||    ..|..|..:|:.|     ..|.|...|.|.| |.         :|::..|
Human    86 RLLAPGYIET----HYGPDGQPVVLAPNHTVRCFHGLWDAPPEDHCHY---------QGRVRGF- 136

  Fly   249 FMEPDDLL------ASEKLERLQRRQRRSRRSAP--SSPDF--------EDL-------NDEDEG 290
               ||..:      ....|..|.|......|..|  .|.||        |.|       ...|.|
Human   137 ---PDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPG 198

  Fly   291 ------ALDGEPQVAESRTRSRRQAPYIIYPEVLVIVDYDGYRLHGGDNLQVKRYFISFWNGVDL 349
                  :|.|.|| :..|..:||...|:   |:.::.|:..:.....:....|:..:...|.||
Human   199 NKAGMTSLPGGPQ-SRGRREARRTRKYL---ELYIVADHTLFLTRHRNLNHTKQRLLEVANYVD- 258

  Fly   350 RYRLLKGPRIRISIAGIIISRGRDATPYLERNRVGRDAIDSAAALTDMGKYLFRERRLPVYDIAV 414
              :||:...|::::.|:.:...||      |:||.:||..:..|.....:.|:.:|   .:|.|.
Human   259 --QLLRTLDIQVALTGLEVWTERD------RSRVTQDANATLWAFLQWRRGLWAQR---PHDSAQ 312

  Fly   415 AITKLDMCRRTSAYGECNRG-TAGFAYVGGACVVNKRLEKVNSVAIIEDTGGFSGIIVAAHEVGH 478
            .:|           |...:| |.|.|.|.|.|    |.|....|:..............|||:||
Human   313 LLT-----------GRAFQGATVGLAPVEGMC----RAESSGGVSTDHSELPIGAAATMAHEIGH 362

  Fly   479 LLGAVHDGSPPPSYLGGPGAQRCRWEDGYIMSDLRHTERGFR--WSACTVQSFHHFLNGDTATCL 541
            .||..||..       |...:......|.:|:  ..|...|.  :|||:.:....|.......||
Human   363 SLGLSHDPD-------GCCVEAAAESGGCVMA--AATGHPFPRVFSACSRRQLRAFFRKGGGACL 418

  Fly   542 HNAPHEDSALGRSLPGT-LLSLDAQCRRDRGTYACFKDERVCAQLFCF--------DAQTGY--- 594
            .|||.....:..:|.|. .:....:|....|        :.|..|.||        .||..:
Human   419 SNAPDPGLPVPPALCGNGFVEAGEECDCGPG--------QECRDLCCFAHNCSLRPGAQCAHGDC 475

  Fly   595 CV--AYRPAA------------------------------EGSAC--GNGYHCLDGRCTPL 621
            ||  ..:||.                              :||.|  |:|| |.||.|..|
Human   476 CVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGY-CWDGACPTL 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	53/231 (23%)
		ADAMTS_CR_2	556..619	CDD:465496	22/108 (20%)
ADAM33	XP_005260900.1	Pep_M12B_propep	<83..174	CDD:460254	25/108 (23%)
		ZnMc_adamalysin_II_like	223..420	CDD:239797	55/235 (23%)
		DISIN	439..513	CDD:214490	12/81 (15%)
		ACR	515..657	CDD:214743	11/22 (50%)