Protein Alignment sona and ADAMTS20

DIOPT Version :9

• Sequence 1: NP_001137746.1
• Gene: sona / 37762
• FlyBaseID: FBgn0034903
• Length: 1102
• Species: Drosophila melanogaster
• Sequence 2: XP_011537056.1
• Gene: ADAMTS20 / 80070
• HGNCID: 17178
• Length: 1911
• Species: Homo sapiens
• Alignment Length: 567
• Identity: 128/567 - (22%)
• Similarity: 211/567 - (37%)
• Gaps: 148/567 - (26%)

  Fly   110 APEVSAIKSHNVSFSAFGQHLNLSLRATQGLFK--------GAPHQLRMWTVGSEPNATHGLDLQ 166
            |.|....::| ..|:|:||...|:|.|......        |.|.: ..|...:.|:     ||:
Human    70 ALEPMPFRTH-YRFTAYGQLFQLNLTADASFLAAGYTEVHLGTPER-GAWESDAGPS-----DLR 127

  Fly   167 EIVHEQHTSNDVGEVFQDEKNMAAILMRRHMETGDL--IMEGSIGHDLVIKPLPHELSPNPEESH 229
            ...:.       |:|...|...|.:.:     .|.|  ..:|..| :..::|:........|:.|
Human   128 HCFYR-------GQVNSQEDYKAVVSL-----CGGLTGTFKGQNG-EYFLEPIMKADGNEYEDGH 179

  Fly   230 ---HIIYKRE-----------ASAAEGQLSD-------FAFMEPDDLLASEKLERLQRRQRRSRR 273
               |:||:::           .|.:|.|:.:       ::.|..|..:..|::      ...:.:
Human   180 NKPHLIYRQDLNNSFLQTLKYCSVSESQIKETSLPFHTYSNMNEDLNVMKERV------LGHTSK 238

  Fly   274 SAPSSPDFEDLNDEDEGALDGEPQVAESRTRSRRQAPYIIYPEVLVIVDYDGYRLHGGDNLQVKR 338
            :.|       |.||            ...:|.:|...|..|.|::|..|......| |.|||  .
Human   239 NVP-------LKDE------------RRHSRKKRLISYPRYIEIMVTADAKVVSAH-GSNLQ--N 281

  Fly   339 YFISFWNGVDLRYRLLKGPR----IRISIAGIIISRGRDATPYLERNRVGRDAIDSAAALTDMGK 399
            |.::..:.|...|   |.|.    |.|.:..:::....:..|.:.        .|.|..|.:...
Human   282 YILTLMSIVATIY---KDPSIGNLIHIVVVKLVMIHREEEGPVIN--------FDGATTLKNFCS 335

  Fly   400 YLFRERRL-----PVYDIAVAITKLDMCRRTSAYGECNRGTAGFAYVGGACVVNKRLEKVNSVAI 459
            :...:..|     ..:|.||.||:.|:|   |:..:||  ..|.:|:|..|      :.:.|..|
Human   336 WQQTQNDLDDVHPSHHDTAVLITREDIC---SSKEKCN--MLGLSYLGTIC------DPLQSCFI 389

  Fly   460 IEDTGGFSGIIVAAHEVGHLLGAVHDGSPPPSYLGGPGAQRCRWEDGYIMSDLRHTE-------- 516
            .|:.|..|...: |||:||.||..||.:|           ||:        :::.|:
Human   390 NEEKGLISAFTI-AHELGHTLGVQHDDNP-----------RCK--------EMKVTKYHVMAPAL 434

  Fly   517 ----RGFRWSACTVQSFHHFLNGDTATCLHNAPHED-SALGRSLPGTLLSLDAQCRR--DRGTYA 574
                ..:.||.|:.:....||:.....||.:.|.|: ..|...|||:....:.||..  ..|:..
Human   435 SFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSELPGSRYDGNKQCELAFGPGSQM 499

  Fly   575 CFKDERVCAQLFCFDAQ---TGYCVAYRPAAEGSACGNGYHCLDGRC 618
            |...|.:|..|:|...:   .|....:.|.|:|:.||.|.||..|.|
Human   500 CPHIENICMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHCRHGLC 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	59/249 (24%)
ADAMTS20	XP_011537056.1	Pep_M12B_propep	64..185	CDD:279848	28/134 (21%)
		Reprolysin	259..467	CDD:279729	60/252 (24%)
		ZnMc_ADAMTS_like	259..464	CDD:239801	59/249 (24%)
		TSP1	560..612	CDD:214559
		ADAM_spacer1	722..841	CDD:283607
		TSP1	971..1024	CDD:214559
		TSP1	1029..1078	CDD:214559
		TSP1	1081..1136	CDD:214559
		TSP1	1160..>1183	CDD:214559
		TSP1	1209..1265	CDD:214559
		TSP1	1363..1417	CDD:214559
		TSP_1	1483..1526	CDD:301595
		GON	1715..1910	CDD:285848

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810