DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sona and ADAM17

DIOPT Version :9

Sequence 1:	NP_001137746.1	Gene:	sona / 37762	FlyBaseID:	FBgn0034903	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	NP_003174.3	Gene:	ADAM17 / 6868	HGNCID:	195	Length:	824	Species:	Homo sapiens

Alignment Length:	607	Identity:	131/607 - (21%)
Similarity:	216/607 - (35%)	Gaps:	172/607 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 VSAIKSHNV---------------SFSAFGQHLNLSLRATQGLFKGAPHQLRMWTVGSEPNATHG 162
            :|.|:.|:|               :|||..:|..|.|.::...|.   ...::..|..:..:.:.
Human    47 LSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERFS---QNFKVVVVDGKNESEYT 108

  Fly   163 LDLQEIVHEQHTSNDVGEVFQDEKNMAAILMRRHMETGDLIME-GSIGHDLVIKPLPHELSPNPE 226
            :..|:.    .|.:.|||  .|.:.:|      |:...|:|:. .:.|.:..|:||...:: :.:
Human   109 VKWQDF----FTGHVVGE--PDSRVLA------HIRDDDVIIRINTDGAEYNIEPLWRFVN-DTK 160

  Fly   227 ESHHIIYKREASAAEGQLSDFAFMEPDDLLASEKLERLQRRQRRSRRSAPSSPDFEDLNDED--- 288
            :...::||                       ||.::.:.|.|      :|....:..:::|:
Human   161 DKRMLVYK-----------------------SEDIKNVSRLQ------SPKVCGYLKVDNEELLP 196

  Fly   289 EGALDGEPQVAESRTRSRRQA---PYIIYPEVLVIVDYDGYRLHG-GDNLQVKRYFISFWNGVDL 349
            :|.:|.||. .|...|.:|:|   |.....::||:.|:..||..| |:......|.|...:.||.
Human   197 KGLVDREPP-EELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDD 260

  Fly   350 RYRL-------LKGPRIRISIAGIIISRGRDATPYLERNRVG-------RDAIDSAAALTDMGKY 400
            .||.       .||..|:|....|:.| .::..|..:...:.       :||.|....|....
Human   261 IYRNTSWDNAGFKGYGIQIEQIRILKS-PQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFS-- 322

  Fly   401 LFRERRLPVYDIAVAITKLDMCRRTSAYGECNRGTAGFAYV--------GGAC------VVNKRL 451
                     :|||...:|:.:. ....|.:.:.||.|.|||        ||.|      .|.|:.
Human   323 ---------FDIAEEASKVCLA-HLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKN 377

  Fly   452 EKVNSVAIIEDTGGFSGII-------VAAHEVGHLLGAVHDGS-----PPPSYLGGPGAQRCRWE 504
            ..:||.  :..|..:...|       |..||:||..||.||..     .|....||.
Human   378 IYLNSG--LTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGK-------- 432

  Fly   505 DGYIMSDLRHT---ERGFRWSACTVQSFHHFLNGDTATCLHNAPHEDSALGRSL--------PGT 558
              |:|..:..:   |....:|.|:.||.:..:......|...  ..:...|.|.        ||.
Human   433 --YVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQE--RSNKVCGNSRVDEGEECDPGI 493

  Fly   559 L-LSLDAQCR-----------RDRGTYACFKDERVCAQLFCFDAQTGYC--VAY----------- 598
            : |:.|..|.           .||.:..|...:...||..|.:|....|  |:|
Human   494 MYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPP 558

  Fly   599 RPAAEGSACGNGYHCLDGRCTP 620
            ..|.:.:.|.:...|.||:|.|
Human   559 GNAEDDTVCLDLGKCKDGKCIP 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	64/272 (24%)
ADAM17	NP_003174.3	Pep_M12B_propep	56..152	CDD:307618	20/110 (18%)
		Cysteine switch. /evidence=ECO:0000250	182..189		0/6 (0%)
		ZnMc_TACE_like	223..477	CDD:239798	64/280 (23%)
		DISIN	484..560	CDD:214490	15/75 (20%)
		ADAM17_MPD	581..641	CDD:318829	131/607 (22%)
		Crambin-like	603..671
		SH3-binding. /evidence=ECO:0000255	731..738
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..824
		SH3-binding. /evidence=ECO:0000255	741..748
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000