DRSC/TRiP Functional Genomics Resources

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Protein Alignment sona and adam12

DIOPT Version :10

Sequence 1:NP_001137746.1 Gene:sona / 37762 FlyBaseID:FBgn0034903 Length:1102 Species:Drosophila melanogaster
Sequence 2:NP_001035103.1 Gene:adam12 / 677729 XenbaseID:XB-GENE-982139 Length:925 Species:Xenopus tropicalis


Alignment Length:428 Identity:95/428 - (22%)
Similarity:140/428 - (32%) Gaps:100/428 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   314 YPEVLVIVDYDGYRLHGGDNLQVKRYFISFWNGVDLRYRLLKGPRIRISIAGIIISRGRDATPYL 378
            |.|::::.|...|:..|.|..:||...|...|.||..:|.|   .||:::.|:.|....|     
 Frog   228 YVELVIVADNREYQRQGKDVDKVKHRLIGMANYVDKFFRPL---NIRVALVGVEIWSDSD----- 284

  Fly   379 ERNRVGRDAIDSAAALTDMGKYLFRERRLP--VYDIAVAITKLDMCRRTSAYGECNRGTA-GFAY 440
             :..:.:|...:.....|..|.    :.||  .:|.|..::           |...:||. |.|.
 Frog   285 -KCSITQDPFTTLQEFLDWRKL----KLLPQKPHDNAQLVS-----------GVYFQGTTIGMAP 333

  Fly   441 VGGACVVNKRLEKVNSVAIIEDTGG--FSGIIVAAHEVGHLLGAVHDGSPPPSYLGGPGAQRCRW 503
            :...|..:|      |..|:.|..|  ....:..|||:||..|..||     :...|...:....
 Frog   334 IMSMCTADK------SGGIVMDHSGNPLGAAVTLAHELGHNFGMNHD-----TLERGCNCRGSAD 387

  Fly   504 EDGYIMSDLRHTERGFRWSACTVQSFHHFLNGDTATCLHNAPHEDSALGRSLPGT-LLSLDAQC- 566
            ..|.||:..........:|:|..:.....|......||:|.|....:.|....|. .:....|| 
 Frog   388 NGGCIMTPSTAYPFPTVFSSCGKKDLDSSLEKGVGMCLYNMPEVTESFGEQKCGNGYVEEGEQCD 452

  Fly   567 --RRDRGTYAC-------FKDERVCAQ-LFCFDAQTGYCVAYRPAAEGSAC-------------- 607
              ..|..|..|       .|...|||. |.|.|.:      .:||  |:.|              
 Frog   453 CGEPDECTNPCCNASLCMLKPGAVCAHGLCCEDCK------LKPA--GTPCRDANNFCDLPEFCS 509

  Fly   608 GNGYHCLDGRCTPLPSNIIPDYGH------NYRLVYNKIDNKKD----------AAEDVESSSEE 656
            |...||        |:|:....||      .|  .||.:....:          |........|.
 Frog   510 GTSAHC--------PANVYLHDGHPCFKIEGY--CYNGVCQTHEQQCITLWGQGAKPAPGICFER 564

  Fly   657 TESQEDETESVEDQDEGTTSSEEQEDNKIEQSSAAGGA 694
            ..|..|...:......|:.:..|..|.|..:....|||
 Frog   565 VNSAGDPYGNCGKDSTGSFTKCENRDAKCGKIQCQGGA 602

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sonaNP_001137746.1 ZnMc_salivary_gland_MPs 313..542 CDD:239800 53/232 (23%)
ADAMTS_CR_2 556..619 CDD:465496 20/88 (23%)
adam12NP_001035103.1 Pep_M12B_propep 58..181 CDD:460254
Reprolysin 227..429 CDD:426256 55/235 (23%)
DISIN 446..520 CDD:214490 21/89 (24%)
ACR 523..665 CDD:214743 16/82 (20%)
PHA03247 <781..924 CDD:223021
Blue background indicates that the domain is not in the aligned region.

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