DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sona and Adamts4

DIOPT Version :9

Sequence 1:	NP_001137746.1	Gene:	sona / 37762	FlyBaseID:	FBgn0034903	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	NP_076449.1	Gene:	Adamts4 / 66015	RGDID:	621242	Length:	851	Species:	Rattus norvegicus

Alignment Length:	519	Identity:	123/519 - (23%)
Similarity:	195/519 - (37%)	Gaps:	124/519 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 AFGQHLNLSLRATQGL--------FKG-APHQLRMWTVGSEPNATHGLDLQEIVHEQHTSNDVGE 180
            |||:.|.|.|....|:        :.| ||..|.    |:||    |..|            .|.
  Rat   101 AFGEILLLELEQDPGVQVEGLTVQYLGQAPEMLG----GAEP----GTYL------------TGT 145

  Fly   181 VFQDEKNMAAILMRRHMETGDLIMEGSI---GHDLVIKPLP-HELSPNPEESHHIIYKREASAAE 241
            :..|.:::|::    |.:.|.|:  |.:   |.:|.::||. ..|:.......||:.::..::..
  Rat   146 INGDPESVASL----HWDRGALL--GVLQYRGAELHLQPLEGGALNSAGGPGAHILRRKSPASNR 204

  Fly   242 GQLSDFAFMEPDDLLASEKLERLQRRQRRSRRSAPSSPDFEDLNDEDEGALDGEPQVAESRTRSR 306
            |.:.:.                          .|||                |.|... || |::
  Rat   205 GPICNV--------------------------KAPS----------------GSPSPI-SR-RNK 225

  Fly   307 RQAPYIIYPEVLVIVDYDGYRLHGGDNLQVKRYFISFWNGVDLRYRLLKGPRIR----ISIAGII 367
            |.|....:.|.||:.|......||..   :|.|.::.   :....:..|.|.||    :.:..::
  Rat   226 RFASLSRFVETLVVADDKMAAFHGAG---LKHYLLTV---MAAAAKAFKHPSIRNPVNLVVTRLV 284

  Fly   368 ISRGRDATPYLERNRVGRDAIDSAAALTDMGKYLF--RERRLPVYDIAVAITKLDMCRRTSAYGE 430
            |.......|     :||..|..:..:.....|.|.  .:.....:|.|:..|:.|:|      |.
  Rat   285 ILGSGQEVP-----QVGPSAAQTLRSFCTWQKGLNPPNDSDPDHFDTAILFTRQDLC------GV 338

  Fly   431 CNRGTAGFAYVGGACVVNKRLEKVNSVAIIEDTGGFSGIIVAAHEVGHLLGAVHDGSPPPSYLGG 495
            ......|.|.||..|      :...|.||:|| .|......||||:||:...:||.|.|.:.|.|
  Rat   339 STCDALGMAGVGTVC------DPARSCAIVED-DGLQSAFTAAHELGHVFNMLHDNSKPCANLNG 396

  Fly   496 PGAQRCRWEDGYIMSD-LRHTERGFRWSACTVQSFHHFLNGDTATCLHNAPHEDSALGRSLPGTL 559
            .|:     ...::|:. :.|.:....||.|:.:....||:.....||.:.|.....|..:.||..
  Rat   397 QGS-----SSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTFPGKD 456

  Fly   560 LSLDAQCRRDRG--TYACFKDERVCAQLFCFDAQTGYCVA---YRPAAEGSACGNGYHCLDGRC 618
            ...|.||:...|  :..|.:....||.|:||....|:.:.   :.|.|:|:.||....|:.|||
  Rat   457 YDADRQCQLTFGPDSSHCPQLPPPCAALWCFGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRC 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	57/235 (24%)
Adamts4	NP_076449.1	Pep_M12B_propep	92..195	CDD:279848	29/119 (24%)
		Reprolysin	232..442	CDD:279729	58/238 (24%)
		ZnMc_ADAMTS_like	232..439	CDD:239801	57/235 (24%)
		ADAM_CR	452..523	CDD:301627	22/69 (32%)
		TSP1	545..589	CDD:214559
		ADAM_spacer1	701..816	CDD:283607
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810