DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sona and adamts15a

DIOPT Version :9

Sequence 1:	NP_001137746.1	Gene:	sona / 37762	FlyBaseID:	FBgn0034903	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	NP_001119901.1	Gene:	adamts15a / 569571	ZFINID:	ZDB-GENE-060526-203	Length:	958	Species:	Danio rerio

Alignment Length:	669	Identity:	159/669 - (23%)
Similarity:	244/669 - (36%)	Gaps:	132/669 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 NHLFAPEVSAIKSHNV-SFSAFGQHLNLSLRATQGLFKGAPHQLRMWTVGSEPNATHGLDLQEIV 169
            |.|...|.|.:....| ..|||.|...|.||:.....  || .....|..:..|:.||.||....
Zfish    39 NSLVDDEDSILPRKAVFKISAFEQDFVLELRSDSSFI--AP-GFSARTDSAAHNSAHGEDLSRCF 100

  Fly   170 HEQHTSNDVGEVFQDEKNMAAILMRRHMETGDLIMEGSIGHD---LVIKPLPHELSPNPEESHHI 231
            :       .|||..|..:.||:.:.:.       ::|:.|:|   ..|||..:....:.|.:|.|
Zfish   101 Y-------AGEVNSDPYSYAALSLCKG-------LQGAFGYDGWEYFIKPASNNTDRDNEAAHLI 151

  Fly   232 IYKREASAAEGQLSDFAFMEPDDLLASEKLERLQRRQRRSRRSAPSSPDFEDLNDEDEGALDGEP 296
               |..|.|:              |:.....|.......::..|.|...|:.|.::....:
Zfish   152 ---RRRSNAD--------------LSGNSTSRCGVDSNATQTVAQSLAKFKHLKEQHMNNV---- 195

  Fly   297 QVAESRTRSRRQAPYIIYPEVLVIVDYDGYRLHGGDNLQVKRYFISFWNGVDLRYRLLKGPRIRI 361
            .::..|.||:|......|.|.||:.|....:.||.|   :|.|.::.   :.:..:|.|.|.|..
Zfish   196 TMSFLRNRSKRFVSIPRYVETLVVADESMAKFHGDD---LKHYVLTL---MSVAAKLYKHPTILN 254

  Fly   362 SIAGIIISRGRDATPYLERNRVGRDAIDSAAALTDMGKYLFRERRL-------PVY-DIAVAITK 418
            ||..:::.       ::..|...:....|..|...:..:...:::|       |.| |.|:..||
Zfish   255 SINIVVVK-------FMVINEEEKGPKVSGNAAMTLRNFCTWQKKLNKNNDKHPEYWDTAILFTK 312

  Fly   419 LDMCRRTSAYGECNRGTAGFAYVGGACVVNKRLEKVNSVAIIEDTGGFSGIIVAAHEVGHLLGAV 483
            .|:|      |.....|.|.|.||..|      :...|.::||| .|.......|||:||:....
Zfish   313 QDLC------GSSTCDTLGMADVGTMC------DPKRSCSVIED-DGLPSAFTTAHELGHVFNMP 364

  Fly   484 HDGSPPPSYLGGPGAQRCRWEDGYIMS-DLRHTERGFRWSACTVQSFHHFLNGDTATCLHNAPHE 547
            ||.......:.|      :.:|.::|| .|....|...||.|:......:|:.....||.:.|.:
Zfish   365 HDNVKACEEVFG------KLQDNHMMSPTLIRINRTSPWSPCSAAIITDYLDSGHGDCLLDQPEK 423

  Fly   548 DSALGRSLPGTLLSLDAQCRR--DRGTYACFKDERVCAQLFCFDAQTGYCVA---YRPAAEGSAC 607
            ..||...|||....|:.||..  ..|:..|...:..|.:|:|.....|..|.   :.|.|:|::|
Zfish   424 PLALPDVLPGASYGLERQCELAFGAGSKPCPFMQAPCQRLWCTGKTRGQLVCQTRHFPWADGTSC 488

  Fly   608 GNGYHCLDGRCTPLPSNIIPDYGHNYRLVYNKIDNKKDAAEDVESSSEETESQEDETESVEDQDE 672
            |:|..|:.|.|.           ....|:..|:|.|........|.|.....
Zfish   489 GDGQLCMRGTCI-----------DKQELLKTKVDGKWGKWGPFGSCSRTCGG------------- 529

  Fly   673 GTTSSEEQEDNKIEQSSAAGGAAAQSTTTARSTTTTTVRTTSTTTTTAKPKSKSFGYLHRSLPER 737
            |...|:.:.||.:..:   ||...|.         ..|:..|...:......||:       .|.
Zfish   530 GVQLSKRECDNPVPVN---GGKYCQG---------VRVKYRSCNLSPCPDTGKSY-------REE 575

  Fly   738 QWMQDNGV-LVTTRISSSV 755
            |....||. |.|.|::|||
Zfish   576 QCEAYNGFSLNTNRLTSSV 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	58/237 (24%)
adamts15a	NP_001119901.1	Pep_M12B_propep	55..151	CDD:279848	29/112 (26%)
		Reprolysin	212..421	CDD:279729	59/240 (25%)
		ZnMc_ADAMTS_like	212..418	CDD:239801	58/237 (24%)
		ADAM_CR	<452..502	CDD:301627	15/60 (25%)
		TSP1	514..566	CDD:214559	11/76 (14%)
		ADAM_spacer1	676..794	CDD:283607
		TSP1	903..957	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810