DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sona and LOC568792

DIOPT Version :9

Sequence 1:	NP_001137746.1	Gene:	sona / 37762	FlyBaseID:	FBgn0034903	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	XP_001922446.3	Gene:	LOC568792 / 568792	-ID:	-	Length:	1224	Species:	Danio rerio

Alignment Length:	653	Identity:	169/653 - (25%)
Similarity:	249/653 - (38%)	Gaps:	169/653 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LVQLQHHENNHNRRRRSIGKGPKVNAALPPHHVK-KDLSKNAYYSELKHEA---LASGGNHLFAP 111
            |:.|..|:..|             .|:...|||| ::|.:..   .|.|:.   |.|  .:...|
Zfish    25 LIVLGCHQRTH-------------CASAAAHHVKHRELLETL---RLPHDTEYELVS--PYEVDP 71

  Fly   112 EVSAIKSHNVS-----------------FSAFGQHLNLSLRATQGLFKGAPHQLRMWTVG-SEPN 158
            |...| ||.||                 ....|:...|.||.::||...   :..:.|:| |...
Zfish    72 EGQYI-SHAVSHQHRSKRSTDASTVHFRLQGLGREFQLDLRPSRGLIAA---EFTVQTLGRSGTR 132

  Fly   159 ATHGLDLQEIVHEQHTSNDVGEVFQDEKNMAAIL----MRRHMETGDLIMEGSIGHDLVIKPL-P 218
            :...||.:.:...|      ||:...|.:..|:.    |...:.|.|.        |..:||| |
Zfish   133 SLQTLDGEMMCFYQ------GELRMQEHSSVALSTCMGMSGLIRTRDA--------DYFLKPLHP 183

  Fly   219 HEL------SPNPEESHHIIYKREA-------------------------SAAEGQLSDFAFMEP 252
            |:.      :|:|:...||:|||.|                         ::.:.:.:....:.|
Zfish   184 HQALLENFSAPSPDHQPHILYKRPAPTNTRRTRRSSEPRPGDPAIPNRWRTSRQAEKNTHTLINP 248

  Fly   253 DDLLASEKLERLQRRQR---RSRRSAPSSPDFEDLNDEDEGALDGEPQVAESRTRSRRQAPY--- 311
            :::..:......:|||.   |.::..|..|:.:.....||..|         ..|.:|...:
Zfish   249 EEMQKTTHKNSTRRRQHYCGRRKKYMPKPPEEDIYIFPDEYKL---------MPRGKRDVVFKPE 304

  Fly   312 ---IIYPEVLVIVDYDGYRLHGGDNLQVKRYFISFWNGVDLRYRLLK----GPRIRISIAG-III 368
               .:..|.||:||......||.:|  :..|.::..|.|.   .|.|    |..|.:.|.| |::
Zfish   305 TQPSLNVETLVVVDRKMMDNHGHEN--ITTYVLTVLNMVS---TLFKDGTIGGNINVVIVGLILL 364

  Fly   369 SRGRDATPYLERNRVGRDAIDS----AAALTDMGKYLFRERRLPVYDIAVAITKLDMCRRTSAYG 429
            ...:|.   |..|......::|    .:.|:.      ||.|.  :|.|:.:|.||:|...:.
Zfish   365 DEDQDG---LVINHHADHTLNSFCQWQSGLSG------REGRR--HDHAILLTGLDICSWKNE-- 416

  Fly   430 ECNRGTAGFAYVGGACVVNKRLEKVNSVAIIEDTG-GFSGIIVAAHEVGHLLGAVHDGSPPPSYL 493
            .|:  |.|||.:.|.|      .|..|..|.|||| |.:..|  |||.||..|.||||.
Zfish   417 PCD--TLGFAPISGMC------SKYRSCTINEDTGLGLAFTI--AHESGHNFGMVHDGE------ 465

  Fly   494 GGPGAQRCRWEDGYIMSDLRHTERG-FRWSACTVQSFHHFLNGDTATCLHNAPH--EDSALGRSL 555
                ...|:...|.|||.......| |.||:|:.|..:.||:...||||.:.|.  ::......|
Zfish   466 ----GNVCKKSVGNIMSPTLAGHNGLFSWSSCSRQYLNRFLSSAQATCLSDEPSAIQEYKYPEKL 526

  Fly   556 PGTLLSLDAQCRRDRGTYA--C---FKDERVCAQLFCFDAQTGYCVAYRPAAEGSACGNGYHCLD 615
            ||.|...|.||:...|..|  |   ||.: :|..|:|..........:.|||||||||....|..
Zfish   527 PGELYDADTQCKWQFGEKAKLCTLDFKKD-ICKALWCHRFGRKCETKFMPAAEGSACGPEMWCRG 590

  Fly   616 GRC 618
            |:|
Zfish   591 GQC 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	74/239 (31%)
LOC568792	XP_001922446.3	Pep_M12B_propep	86..203	CDD:279848	28/133 (21%)
		ZnMc_ADAMTS_like	309..510	CDD:239801	73/238 (31%)
		Reprolysin	311..514	CDD:279729	75/240 (31%)
		TSP1	617..660	CDD:214559
		ADAM_spacer1	765..876	CDD:283607
		TSP1	1067..1124	CDD:214559
		TSP1	1133..1181	CDD:214559
		PLAC	1190..1220	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810