DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sona and adamts5

DIOPT Version :9

Sequence 1:	NP_001137746.1	Gene:	sona / 37762	FlyBaseID:	FBgn0034903	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	NP_001289160.1	Gene:	adamts5 / 565053	-ID:	-	Length:	937	Species:	Danio rerio

Alignment Length:	875	Identity:	183/875 - (20%)
Similarity:	287/875 - (32%)	Gaps:	255/875 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 VIKPLPHELSPNPEESHHIIYKREASAA-----EGQLSDFAFMEPDDLLASEKLERLQRRQRRSR 272
            ||:...|      |...||:...:|:.|     ..:.|..|..|.......::..|..:::...|
Zfish   119 VIRAKGH------ENDVHIVEDADATRALHLYTRERFSFEAMPERHSCGTRDRKTRKHKKEMHGR 177

  Fly   273 R--SAPSSPDFEDLNDEDEGALDGEPQVAESRTRSRRQAPYIIYPEVLVIVDYDGYRLHGGDNLQ 335
            |  :....||                   .|.||.:|......:.|:|::.|....:.:|.|
Zfish   178 RWWTKFIRPD-------------------ASPTRRKRSVSRARHVELLLVADASMTKKYGKD--- 220

  Fly   336 VKRYFISFWNGVDLRY--RLLKGPRIRISIAGIIISRGRDATPYLERNRVGRDAIDSAAALTDMG 398
            ::.|.::..:.....|  ..::.| ||:|:..:.:....:....:.:|        :||.|....
Zfish   221 LQHYLLTLASIASKLYGHASIENP-IRLSVVKVALLSEHEKGIEISKN--------AAATLKSFC 276

  Fly   399 KYLFRERRLPV-------YDIAVAITKLDMCRRTSAYGECNRGTAGFAYVGGACVVNKRLEKVNS 456
            |:  :.::.|:       :|.|:..|:.|:|    .:..|:  |.|.|.||..|...:      |
Zfish   277 KW--QNQQNPLDDDHQHHHDAAILFTRQDLC----GHHSCD--TLGMADVGTVCSPER------S 327

  Fly   457 VAIIEDTGGFSGIIVAAHEVGHLLGAVHDGSPPPSYLGGPGAQRCRWEDGYIMSD-LRHTERGFR 520
            .|||||.|..:...| |||:|||||..||.|.......|..      ||..:||. |...:....
Zfish   328 CAIIEDDGLHAAFTV-AHEIGHLLGLSHDDSKFCEERFGSS------EDKRLMSSILTSIDASKP 385

  Fly   521 WSACTVQSFHHFLNGDTATCLHNAPHEDSALGRSLPGTLLSLDAQCRRDRGT-YACFKDERVCAQ 584
            ||.||..:...|.:...|.||.:||.........|||.......|||...|: |:......:||:
Zfish   386 WSRCTSNTITDFFDDGNAECLLDAPRVPLLGPEELPGQSYDAVQQCRLAFGSEYSVCPGMDICAR 450

  Fly   585 LFCFDAQTGYCVAYR---PAAEGSACGNGYHCLDGRC---------------------------- 618
            |:|...:.|..|...   ||.||:.||.|..||.|:|
Zfish   451 LWCSVIRKGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKRHYSTSKDGSWSSWGAWGSCSR 515

  Fly   619 --------------TPLPSN------------------IIPDYGHNYRLVYNKIDN--------- 642
                          .|.|.|                  ..|..|.::|....::.|
Zfish   516 SCGGGVQFAQRLCNNPAPRNNGRYCTGKRAVYRSCSVTPCPTTGKSFRQEQCEVRNGPQTDPKGV 580

  Fly   643 --------------KKDAAEDVESSSEETE-----SQE--DETE-------------SVEDQDEG 673
                          .||..: :...::.|.     ||.  |.||             .|....:|
Zfish   581 KTLVEWVPKFAGVLPKDVCK-LTCRAKGTGYYVVFSQRVVDGTECRPYSSSVCVKGKCVRTGCDG 644

  Fly   674 TTSSEEQEDNKIEQSSAAGGAAAQSTTTARSTT------TTTVRTTSTTT------TTAKPKSKS 726
            ...|:.|.|    :....||........|.:.|      |..|:....:|      ..||.:|:.
Zfish   645 IIGSKLQYD----KCGICGGDGNSCIKVAGNFTKKSKGYTDVVKIPEGSTHLKVRQYKAKGQSRY 705

  Fly   727 FGYLHRSLPERQWMQDNGVLVTTR-----ISSSVSSSSSGSSSGEAAATSTRRPTTTTTTQTPNL 786
            ..||....|...::.:..::::|.     ::.||.:.:..|...||.     ........|...|
Zfish   706 TAYLALRRPGGDYLLNGKLMISTSETIIPLNGSVLNYTGWSQRDEAF-----HSMGPAALQESLL 765

  Fly   787 FQIYTHELRK--QIEYYLHMLQTQQHATKFQPEQQQQQSQQQQSIVEIPLVQKSLTNYSVTSSSS 849
            .||.:.:.:|  .|.|...|.:......:..||...:.|      :|.| .:.||
Zfish   766 VQILSTDAKKPLDIRYSFFMPRKTPLPARTSPEAPPRMS------LEAP-PRMSL---------- 813

  Fly   850 STSNGAKQQPPSNKDENQRQQQQQQQAQQQLQDGLPDEENEATAGIQSNEAIERQKRKFPTTPTA 914
                   :.||         :...:...:...:.||....||...|.. ||..|...:.|.|..:
Zfish   814 -------EAPP---------RMSLEAPPRMAPEALPRTSPEAPPRIPP-EAPPRTPPEAPPTVAS 861

  Fly   915 ATSAAQKSATPATPATSATSARPTPTTAKP 944
            .:||...:.|...|          |||..|
Zfish   862 LSSAELVTFTSDVP----------PTTESP 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	61/238 (26%)
adamts5	NP_001289160.1	Pep_M12B_propep	32..132	CDD:279848	5/18 (28%)
		Reprolysin	201..410	CDD:279729	62/241 (26%)
		ZnMc_ADAMTS_like	201..407	CDD:239801	61/238 (26%)
		ADAM_CR	<436..490	CDD:301627	19/53 (36%)
		TSP1	504..556	CDD:214559	3/51 (6%)
		ADAM_spacer1	667..786	CDD:283607	24/123 (20%)
		TSP1	886..>914	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910