DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sona and adgrb1a

DIOPT Version :9

Sequence 1:	NP_001137746.1	Gene:	sona / 37762	FlyBaseID:	FBgn0034903	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	XP_009290826.1	Gene:	adgrb1a / 563527	ZFINID:	ZDB-GENE-060607-12	Length:	1610	Species:	Danio rerio

Alignment Length:	531	Identity:	99/531 - (18%)
Similarity:	158/531 - (29%)	Gaps:	189/531 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 ALTDMGKYL-FRERRLPVYDIAVAITKLDMCRRTSAYGECNRGTAGFAYVGGACVVNKRLEKVNS 456
            |||.|...| ..:||..::.|..|:..               ...||..|...|::.:.:::...
Zfish  1178 ALTWMSAVLAITDRRSALFQILFAVFD---------------SLEGFVIVMVHCILRREVQEAVK 1227

  Fly   457 VAII---EDTGGFSGIIVAAHEVGHLLGAVHDGSPPPSYLGGPGAQ-----------RCRWEDGY 507
            ..::   ||..|.||   .:.:.||                   ||           .||  .|.
Zfish  1228 CRVVDRQEDGNGDSG---GSFQNGH-------------------AQLMTDFEKDVDIACR--SGT 1268

  Fly   508 IMSDLRHTERGFRWSACTVQSFHHFLNGDTATCLHNAPHEDSALGRSLPGTLLSLDAQ------- 565
            :....:..|........|||...:|                    .:||.::..:..|
Zfish  1269 LKRPSQQGEEKVPSQQITVQKGSNF--------------------NTLPASMAKVHLQNVANYAS 1313

  Fly   566 ----CRRDRGTYACFKDE-------RVC-AQLF-CFDAQTGYCVAYRPAAEGSACGNGYHCL--- 614
                .|||:|..|....|       .:| .:|| ..|...|..    |...|...|.||..|
Zfish  1314 HTLTMRRDKGAIAGVSTELPGAKSIYICDGELFKQLDGAPGDI----PEGGGGGAGQGYVLLPNN 1374

  Fly   615 --------DGRCTPLPS-NIIPDYGHNYRLVY--NKIDN--------KKDAAEDVESSSEETESQ 660
                    .|:..|... ||..:.....||::  |.:..        |....:.|..|..|.||.
Zfish  1375 NNTLRPTKGGKEDPAAKYNISIEQLPQTRLIHLANPVGTDPVAGFGLKSLPTDRVSVSCSERESP 1439

  Fly   661 EDETESVEDQDEGTTSSEEQEDNKIEQSSAAGGAAAQSTTTARSTTTTTVRTTSTTTT------- 718
            ....:::        |||.|..|..||..:.....::|.|.:..:.::..|..|....
Zfish  1440 VQTVQNI--------SSESQMTNTCEQGDSGNSGMSKSETVSTLSMSSLERRKSRYAELDFEKIM 1496

  Fly   719 -TAKPKSKSFGYLHRSL---------------PERQWMQDNGVLVTTRISSSVSSSSSGSSSGEA 767
             |.|.....|..|:|.|               |.::|...:|....|.:|....:.|..:..|
Zfish  1497 HTRKRHQDMFQDLNRKLQHAEKDRDSPPVDCKPGKRWSISSGGSDKTNLSDKQQTPSKRAWEG-- 1559

  Fly   768 AATSTRRPTTTTTTQTPNLFQIYTHELRKQIEYYLHMLQTQQHATKFQPEQ----QQQQSQQQQS 828
                      ...|.:|..:      :||::|                |.|    :.|..:.:::
Zfish  1560 ----------IRKTHSPPSW------VRKELE----------------PLQASPLEMQAVEWEKA 1592

  Fly   829 IVEIPLVQKSL 839
            ...||||.:.:
Zfish  1593 SATIPLVGQEI 1603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	30/163 (18%)
adgrb1a	XP_009290826.1	TSP1	242..291	CDD:214559
		TSP1	360..408	CDD:214559
		TSP1	418..468	CDD:214559
		TSP1	473..523	CDD:214559
		TSP1	528..578	CDD:214559
		HRM	580..646	CDD:295297
		GAIN	665..860	CDD:293098
		GPS	886..930	CDD:280071
		7tm_4	944..1211	CDD:304433	11/47 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900