DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sona and adamts7

DIOPT Version :9

Sequence 1:	NP_001137746.1	Gene:	sona / 37762	FlyBaseID:	FBgn0034903	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	XP_021333676.1	Gene:	adamts7 / 560364	-ID:	-	Length:	1808	Species:	Danio rerio

Alignment Length:	1372	Identity:	258/1372 - (18%)
Similarity:	415/1372 - (30%)	Gaps:	516/1372 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 FHVDTH---DAVPHYELV-------------QLQHHENNHNRRRRSIGKGPKVNAALPPHHVKKD 86
            ::.||.   ..||.||:|             .|..|..:..:||.:             ...|:.
Zfish    53 YNQDTDGSLSGVPSYEVVYPIRVDSSGHFLSNLVSHRVSRIQRRET-------------EKSKER 104

  Fly    87 LSKNAYYSELKHEALASGGNHLFAPEVSAIKSHNVSFSAFGQHLNLSLRATQGLFKGAPHQLRMW 151
            |::..||       |..||..|                    |.||:|.         ||.|...
Zfish   105 LTQVYYY-------LQYGGQDL--------------------HFNLTLN---------PHLLAPG 133

  Fly   152 TV------GSEPNATHGLDLQEIVHEQHTSNDVGEVFQD--EKNMAAILMRRHMETGDLIMEGSI 208
            .:      |.:.:..||       |.......:|:|:..  :...||:          ....|..
Zfish   134 FLTERRYGGLQGSTLHG-------HGHSLCFFLGDVWSSMLKSGQAAV----------STCNGLT 181

  Fly   209 G------HDLVIKPLPHELSPNPEESHHIIYKREASAAEGQLSDFAFMEPDDLL------ASEKL 261
            |      .:..|.||..|...:..:: |.||||.|..:|.||....|.|.....      .:|:.
Zfish   182 GLFKLSEEEFFISPLEQEQEESTTQA-HAIYKRHAVQSERQLVQPLFGEHTANATCGVKGGAEQF 245

  Fly   262 ERLQRRQRRSRRSAPSSPDFEDLNDEDEGALDGEPQVAESRTRSRRQAPYIIYPEVLVIVDYDGY 326
            || ||.:..||:                       |....|.||.....::   |.||:.|....
Zfish   246 ER-QRERWESRQ-----------------------QRKRIRQRSISTEKWV---ETLVVADPKMV 283

  Fly   327 RLHGGDNLQVKRYFISFWNGVDLRYRLLK-GPRIRISIAGIIISRGRDATPYLERN----RVGRD 386
            ..||...  |..|.:|..|.|...:|... |..|.|::..:::         ||::    ::...
Zfish   284 EYHGSKG--VVSYVLSVMNIVAGLFRDASIGNAINIAVVRLVL---------LEKDEEDLKITHH 337

  Fly   387 AIDSAAALTDMGKYL-FRERRLPV-YDIAVAITKLDMCRRTSAYGECNRGTAGFAYVGGACVVNK 449
            |.:|..:.....|.: .::...|| :|:||.||:.|:|...:...|    |.|.::|.|.|..::
Zfish   338 ADNSLHSFCKWQKNINMKDDDHPVHHDVAVLITRKDICAAINKPCE----TLGLSHVAGMCQPHR 398

  Fly   450 RLEKVNSVAIIEDTG---GFSGIIVAAHEVGHLLGAVHDGSPPPSYLGG---PGAQRCRWEDGYI 508
                  |.:|.||||   .|:    .|||:||..|..|||:      |.   |..:|     .::
Zfish   399 ------SCSINEDTGLPLAFT----IAHELGHNFGIQHDGN------GNDCEPIGKR-----PFV 442

  Fly   509 MS-DLRHTERGFRWSACTVQSFHHFLNGDTATCLHNAP-HEDSALGRSLPGTLLSLDAQCRRDRG 571
            || .|.:......||.|:.:....||:.....||.:.| ..:..|..:.||.|.|...||:...|
Zfish   443 MSPQLLYGTSPPNWSRCSREYITRFLDRGWGWCLDDPPVRNELDLHPAPPGVLYSAAHQCKLQYG 507

  Fly   572 TYACFKDE--RVCAQLFCFDAQTGYCVAYRPAAEGSACGNGYHCLDGRC---------------- 618
            :.:...||  .:|:.|:|....|.:. ....|.:|:.||....|.||.|
Zfish   508 SSSLLCDEVDNICSTLWCTVGSTCHS-RLDGAVDGTKCGEDKWCFDGECVTKGTQPESVHGGWAS 571

  Fly   619 -----------------------TPLPS------------------------------------N 624
                                   .|:|.                                    |
Zfish   572 WSDWSDCSRTCGTGVQNAQRDCINPVPKYGGRYCLGERQRYRTCNHESCPVDQPSFRHMQCSRFN 636

  Fly   625 IIPDYGHNYRLVY--NKI---------------DNKKDAAEDVESSSEETESQ------------ 660
            .:|..|..|:.::  |::               :...|...|.....|.::|:
Zfish   637 TVPYKGKFYKWIHVNNRVNPCELHCRPMNEHFSERMLDTVIDGTQCYEGSQSRDICVNGICKYLG 701

  Fly   661 ---EDETESVEDQ-----DEGTT------SSEEQE---------------DNKIEQSSAAGGAAA 696
               |.::::||||     ..|:|      :.|:.|               |.:||:.:.||...|
Zfish   702 CDFEIDSDAVEDQCGVCLGNGSTCETVRKTFEDSEGLGYVDIGLIPEGARDIRIEEVAEAGNYLA 766

  Fly   697 QSTT-------------------TARSTTTTTVRT-----TSTTTTTAKPKSKSFGYLHRSLPER 737
            ..:.                   .|..|..|..||     .|:...|.:|
Zfish   767 LRSNDPEKYFLNGGWTIQWNGEYKAAGTIFTYERTGQLENLSSPGPTMEP--------------- 816

  Fly   738 QWMQ------DNGVLVTTRIS-SSVSSSSSGSSSG----------EAAA---TSTRRPTTTTTTQ 782
            .|:|      :.||.....|| .::..||:|::..          |.:|   |..:|.......:
Zfish   817 VWIQLLFQETNPGVRYEYTISRDTLLDSSNGTAVSYFQWIYGAWTECSATCGTGMQRQIVHCVEK 881

  Fly   783 TPNLFQIYTHELRKQIEYYLHMLQTQQHATKFQPEQQQQQSQQQQSIVEIPLVQKSLT------- 840
            |..:.:          |:|..        ...:|:.:|..            ..|.|.
Zfish   882 TSGIVE----------EHYCD--------ASMRPDDKQTS------------CNKGLCPAIWWAG 916

  Fly   841 NYSVTSSSSSTSNGAKQQPPSNKDENQRQQQQQQQAQQQLQDGLPDEEN------------EATA 893
            ::...|||.......|:.....:.....:|:..|.|:.|   .||..|:            :.|.
Zfish   917 DWQKCSSSCGEMGLRKRTVLCIRSLGLDEQRALQPAECQ---HLPKPESIIPCNTQVSCPADWTT 978

  Fly   894 GIQSNEAIERQKRKFPTTPTAATSAAQKSAT-------PATPATSATSARPTPTTAKPITTSSFL 951
            |..|..::           :.||....:..|       ...|.....|..|......||.|.
Zfish   979 GSWSECSV-----------SCATGLRIRDVTCRWNTGSDCDPKAKPNSTMPCYAQDCPINTD--- 1029

  Fly   952 DAYFKKLQALHD-AGSASSSTTTTTTTSVSSSVSSATSSKQQHPQQQQQQQVQQIADGSHF--LK 1013
                     :.| :||.:||........|.......:.:|.|..|......:.: .|.||:  ::
Zfish  1030 ---------ISDWSGSGASSKEVFNEIDVIPHDGHFSQTKNQPRQNADLNDIVE-NDFSHYNHIE 1084

  Fly  1014 RTPHRSSLK----------------------------AYKTSS-----------SSSNNSSSQTQ 1039
            ::|..|.:|                            |:..|.           |::..||..|.
Zfish  1085 KSPENSIVKNLHVDDFYYDYNFIKFHEDLSYDLDEDDAFDNSGIKHKDLTGTYVSNTTTSSPSTT 1149

  Fly  1040 QQQQQQQQQYATNYIGDTTNNQPAVLDNSGSASSTTE------------TAKKPKIKTQKLIRRT 1092
            ..|......|:.:....|..::|   .|.|.|....:            |..:|.....:|..:.
Zfish  1150 ADQHSTATMYSDSITKGTEGHKP---PNKGIADDNNDALFAEDYLLPVITTTEPTSSVTRLFNKL 1211

  Fly  1093 RVMQTQT 1099
            :...|.:
Zfish  1212 KASGTDS 1218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	63/242 (26%)
adamts7	XP_021333676.1	Pep_M12B_propep	68..211	CDD:307618	36/209 (17%)
		ZnMc_ADAMTS_like	270..477	CDD:239801	63/245 (26%)
		ADAM_CR	<513..556	CDD:326582	13/43 (30%)
		ADAM_CR	540..697	CDD:326582	18/156 (12%)
		TSP1	569..621	CDD:214559	2/51 (4%)
		ADAM_spacer1	726..836	CDD:310520	20/124 (16%)
		TSP1	855..910	CDD:214559	11/84 (13%)
		TSP1	976..1025	CDD:214559	9/59 (15%)
		Herpes_U47	<1363..>1441	CDD:283192
		TSP1	1588..1646	CDD:214559
		TSP_1	1651..1695	CDD:326556
		TSP1	1698..1755	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910