Protein Alignment sona and ADAM22

DIOPT Version :10

• Sequence 1: NP_001137746.1
• Gene: sona / 37762
• FlyBaseID: FBgn0034903
• Length: 1102
• Species: Drosophila melanogaster
• Sequence 2: XP_006716091.1
• Gene: ADAM22 / 53616
• HGNCID: 201
• Length: 1024
• Species: Homo sapiens
• Alignment Length: 1235
• Identity: 201/1235 - (16%)
• Similarity: 357/1235 - (28%)
• Gaps: 520/1235 - (42%)

  Fly    37 VFHVDTHDAVPHY------ELVQLQHHENNHNRRRRSIGKGPKVNAALPPHHVKKDLSKNAYYSE 95
            :|....|..:..:      .|::|:..:.|....|:||         :|...:.:...::    |
Human    65 IFAFSLHSLLSRFLPGGDASLMELEKRKENRFVERQSI---------VPLRLIYRSGGED----E 116

  Fly    96 LKHEALAS------GGNHLFAPEVSAIKSHNVSFSAFGQH------LNLSLRATQGLFKGAPHQL 148
            .:|:||.:      ||     |:::.:...:....|||..      ||..|.:::.:
Human   117 SRHDALDTRVRGDLGG-----PQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYI-------- 168

  Fly   149 RMWTVGSEPNATHGLDLQEIVHEQHTSNDVGEVFQDEKNMAAILMRRHMETGDLIMEGSIGHDLV 213
                   |.:..||....|:...:|.... |.:..:..:..| |...|...| :..:|:  |..:
Human   169 -------ERHIEHGGKTVEVKGGEHCYYQ-GHIRGNPDSFVA-LSTCHGLHG-MFYDGN--HTYL 221

  Fly   214 IKPLPHELSPNPEESH-HIIYKREASAAEGQLSDFAFMEPDDL--------LASEKLERLQRRQR 269
            |:  |.|.....|:.| |.:||       .:|.:|:.   |||        :...|. .|:.|.:
Human   222 IE--PEENDTTQEDFHFHSVYK-------SRLFEFSL---DDLPSEFQQVNITPSKF-ILKPRPK 273

  Fly   270 RSRRSAPSSPDFEDLNDEDEGALDGEPQVAESRTRSRRQAPYIIYPEVLVIVDYDGYRLHGGDNL 334
            ||:|.                 |...|:..|..|:         |.|::::.|:..::.|....:
Human   274 RSKRQ-----------------LRRYPRNVEEETK---------YIELMIVNDHLMFKKHRLSVV 312

  Fly   335 QVKRYFISFWNGVDLRYRLLKGPRIRISIAGIIISRGRDATPYLERNRVGRDAIDSAAALTDMGK 399
            ....|..|..|..||.|:.....||      ::::....||             |:..|:::...
Human   313 HTNTYAKSVVNMADLIYKDQLKTRI------VLVAMETWAT-------------DNKFAISENPL 358

  Fly   400 YLFRE----RRLPVYDIAVAITKLDMCRRTSAYGECNRGTAGFAYVGGACVVNK-----RLEKVN 455
            ...||    ||..:.:.:.|:...     :.:..|.:|  :|.||:||.|.:.|     ...|.:
Human   359 ITLREFMKYRRDFIKEKSDAVHLF-----SGSQFESSR--SGAAYIGGICSLLKGGGVNEFGKTD 416

  Fly   456 SVAIIEDTGGFSGIIVAAHEVGHLLGAVHDGSPPPSYLGGPGAQRCRWED---GYIMSDLRHTER 517
            .:|           :..|..:.|.:|.:.|.....|       ..|:.||   |.||.|     .
Human   417 LMA-----------VTLAQSLAHNIGIISDKRKLAS-------GECKCEDTWSGCIMGD-----T 458

  Fly   518 GF----RWSACTVQSFHHFLNGDTATCLHNAPHE------------------------------- 547
            |:    :::.|.::.:|.|||.....||.|.|.:
Human   459 GYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGA 523

  Fly   548 ----------------------------------------------------------------D 548
                                                                            |
Human   524 ECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCD 588

  Fly   549 SALGRSLPGTLLSLDAQCR-----------------------------RDRGTY-ACFKDERVCA 583
            ...|....|...:.|.||:                             :|:.|: .|.|.:.:|.
Human   589 GVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCG 653

  Fly   584 QLFCF--------------------------------------DAQTGYCVAYRPAAEGSACGNG 610
            .|.|.                                      |...||      ..:|:.||..
Human   654 YLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGY------VEDGTPCGPQ 712

  Fly   611 YHCLDGRCTPLPSNIIPDYGHNYRLVYNKIDNKKDAAEDVESSSEETESQ-----EDETESVEDQ 670
            ..||:.||.|:.|       .|:....              ||.|.|...     .:|.:.|.::
Human   713 MMCLEHRCLPVAS-------FNFSTCL--------------SSKEGTICSGNGVCSNELKCVCNR 756

  Fly   671 ----DEGTTSSEEQEDNKIEQSSAAGGAAAQSTTTARSTTTTTVRTTSTTTTTAKPKSKSFGYLH 731
                .:..|.....:|.|...:.:..|.|..:........|..|.......|       ::||.:
Human   757 HWIGSDCNTYFPHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGIT-------AWGYKN 814

  Fly   732 ----RSLPERQWMQDNG------VLVTTRISSSVSSSSSGSSSGEAAATSTRRPTTTTTTQTPNL 786
                |.||:..:::..|      ..:...:|::.:|||...|:|.:.:.|.|.|.|
Human   815 YREQRQLPQGDYVKKPGDGDSFYSDIPPGVSTNSASSSKKRSNGLSHSWSERIPDT--------- 870

  Fly   787 FQIYTHELRKQIEYYLHMLQTQQHATKFQPEQQQQQSQQQQSIVEIPLVQKSLTNYSVTSSSSST 851
                                  :|.:......:.:.:..|.::                ..:...
Human   871 ----------------------KHISDICENGRPRSNSWQGNL----------------GGNKKK 897

  Fly   852 SNGAKQQPPSNKDENQRQQQQQQQAQQQLQDGLPDEENEATAGIQSNEAIERQKRKFPTTPTAAT 916
            ..|.:.:|.||..|.:.|..:...:..|                              |.|:...
Human   898 IRGKRFRPRSNSTEREPQAPEPGHSLAQ------------------------------TVPSQGI 932

  Fly   917 SAAQKSATPATPATSATSARPTPTTAKPITTSSFLDAYFKK-------------------LQALH 962
            |.....    :|.|.:...|             :|:.:||:                   .:.|.
Human   933 SPGGSD----SPQTGSLDHR-------------YLNPWFKRDYNVAKWVEDVNKNTEGPYFRTLS 980

  Fly   963 DAGSASSSTTTTTTTSVSSSVSSATSSKQQHPQQQQQQQVQQIADGSHFLKRTPHRSSLKAYKTS 1027
            .|.|.||||.           |.|:|.|..:|......:.:::           :|.|.:.::||
Human   981 PAKSPSSSTG-----------SIASSRKYPYPMPPLPDEDKKV-----------NRQSARLWETS 1023

  Fly  1028  1027
            Human  1024  1023

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	51/244 (21%)
		ADAMTS_CR_2	556..619	CDD:465496	20/130 (15%)
ADAM22	XP_006716091.1	Pep_M12B_propep	123..240	CDD:460254	27/143 (19%)
		Reprolysin	291..490	CDD:426256	53/256 (21%)
		Disintegrin	505..578	CDD:459709	0/72 (0%)
		ACR	582..723	CDD:214743	23/146 (16%)