DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sona and AdamTS-A

DIOPT Version :9

Sequence 1:	NP_001137746.1	Gene:	sona / 37762	FlyBaseID:	FBgn0034903	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster

Alignment Length:	678	Identity:	159/678 - (23%)
Similarity:	242/678 - (35%)	Gaps:	210/678 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 VFHVDTHDAVPH---YELVQLQHHENNHNRRRRSIGKGPKVNAALPPHHVKKDLSKNAYYSELKH 98
            :||:....|  |   .||.|..|...|         ..|...|.|.|..:..|.|.:       |
  Fly   176 MFHLGLRSA--HKGQEELPQSTHPLAN---------SPPATPATLHPRRLDNDTSTD-------H 222

  Fly    99 EALASGGNHLFAPEVSAI----KSHNVSFSAF--------GQHLNLSLR------ATQGLFKGAP 145
            |. ..|.:.|...|.||.    |.:|.|.|..        ...:|..|:      |..|.::...
  Fly   223 EP-PDGLDDLDEEEHSAFVMPTKVYNYSLSEADLIYESKRNSDINSFLKESASAFAMTGTYRNMS 286

  Fly   146 HQLRMWTVGSEPNATHGLDLQEIVHEQHTSNDVGEVFQDEKNMAAILMRRHMETGDLIMEGSIGH 210
            :::  |    :|            |.|:..|..|..........|..:..|          |:.|
  Fly   287 NEI--W----DP------------HPQYNLNVFGRQLHLVLRQDASFVHNH----------SMTH 323

  Fly   211 DLVIKPLPHELSPNPEESHHIIYKREASAAEGQLSDF--AFMEPDD------------------- 254
            ..::|  ..|..|.||        .||.|.:..|..|  .::|.|.
  Fly   324 IRILK--EGEEHPGPE--------TEAEAEQRHLGCFYSGYVEDDPHSMVSVSLCGGMTGYIKTS 378

  Fly   255 ---LL--------ASEKLERLQRRQRRSRRSAPSS-----PDF----EDLNDEDEGALDGEPQVA 299
               ||        :.|.|.|:.|:.:|:.|.|.|.     .||    |.:.:|:        |.:
  Fly   379 FGALLIQPVNRTSSDEVLHRVFRKSQRNARHAVSKFELGLDDFMSKLEQVQEEE--------QKS 435

  Fly   300 ESRTRSRRQAPYI-----IYP-EVLVIVDYDGYRLHGGDNLQVKRYFISFWNGVDLRYRLLK-GP 357
            :||..:|::..|.     :|. |||:.||....:.||.|   ::.|.:...:.|...:.... |.
  Fly   436 KSRKLNRKKRHYADVDNQVYTLEVLIAVDNSMKQFHGED---LQPYILILMSIVSSIFADASIGN 497

  Fly   358 RIRISIAGIIISRGRDATPYLERNRVGRDAIDSAAALTDMGKYLFR-------ERRLPVYDIAVA 415
            .|||.:..:|      :.|.:.         |...:..:|.|:..:       ||     |.|:.
  Fly   498 SIRILLVRLI------SLPNIN---------DQTHSSNEMLKHFCQFINQSGYER-----DTAML 542

  Fly   416 ITKLDMCRRTSAYGE-CNRGTAGFAYVGGACVVNKRLEKVNSVAIIEDTGGFSGIIVAAHEVGHL 479
            ||:..:|  .|..|: |:  ..|.|.:|..|       ..:|.:|::|| |.......|||:||:
  Fly   543 ITREPIC--GSVPGKICH--MLGLAELGTVC-------SSSSCSIVQDT-GLPTAFTMAHELGHI 595

  Fly   480 LGAVHDGSPPPSYLGGPGAQRC-----RWEDG---YIMSDLRHTE-RGFRWSACTVQSFHHFLNG 535
            |...||..           .:|     |..:.   :|||.:.... ..:.||.|:......||..
  Fly   596 LNMNHDDD-----------DKCMPYVTRQNNNKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEK 649

  Fly   536 DTATCLHNAPHEDSALG-RSLPGTLLSLDAQCRRDRGT---YACFKDERVCAQLFCFDAQTG--- 593
            ...:||..:.......| ..|||.:.||||||:...|.   | |..||. |.:|:| :..:|
  Fly   650 TDKSCLETSVGAHIPYGTERLPGEIYSLDAQCQLSFGNDFGY-CPTDEE-CKRLWC-NRTSGNSN 711

  Fly   594 -YCVAYR-PAAEGSACG-NGYHCLDGRC 618
             .|.:.. |.|:|:.|| :|:.|..|:|
  Fly   712 EQCASSNLPWADGTPCGSSGHWCQRGKC 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	58/247 (23%)
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	24/145 (17%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	57/245 (23%)
		Reprolysin	457..655	CDD:279729	56/243 (23%)
		Salp15	<696..745	CDD:288931	15/46 (33%)
		TSP1	754..806	CDD:214559
		ADAM_spacer1	937..1042	CDD:283607
		TSP1	1172..1229	CDD:214559
		GON	1495..1687	CDD:285848
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13723
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910