DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sona and stl

DIOPT Version :9

Sequence 1:	NP_001137746.1	Gene:	sona / 37762	FlyBaseID:	FBgn0034903	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	NP_001097423.1	Gene:	stl / 37619	FlyBaseID:	FBgn0086408	Length:	1136	Species:	Drosophila melanogaster

Alignment Length:	1169	Identity:	239/1169 - (20%)
Similarity:	360/1169 - (30%)	Gaps:	399/1169 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 VFHVDTHDAVPHYELVQL---------------------QHHENNHNRR-RRSI----GKGPKVN 75
            :|...:.:..|.::||.|                     ||..|.|.|| |||:    |.||
  Fly    77 IFGSRSPEEAPEFKLVHLAQQRPEEQQRLEERKRPGEAEQHGGNPHQRRQRRSLPSEDGNGP--- 138

  Fly    76 AALPPHHVKKDLSKNAYYS-ELKHEALASGGNHLFAPEVSAIKSHNVSFSAFGQHLNLSLRATQG 139
              |||...:::..::.... :|:..........:|.....       :.:.|.:|....|:..:.
  Fly   139 --LPPEEEEQEAGEDVEARLQLQQSPQLIDDAFIFIRRTE-------NGTQFVEHSPQLLKRLER 194

  Fly   140 LFKGAPHQLRMWTVGSEPNATHGLDLQEIVHEQHTSNDVGEVFQDEKNMAAILMRRHMETGDLIM 204
            .|..:|              ...|||.|       ..:|..|||..
  Fly   195 CFYRSP--------------AAALDLCE-------PGNVRGVFQQN------------------- 219

  Fly   205 EGSIGHDLVIKPLPHELSPNPEESHHIIY----------------KREASAAEGQLSDFAFMEPD 253
                |.||||.|||.......    |::|                :|.||..:.||.    .|||
  Fly   220 ----GSDLVIHPLPARFGTGT----HVLYQARVDKSGGGYSEASSRRTASPLDSQLQ----FEPD 272

  Fly   254 DLLASEKLERL----------------------QRRQRRSRRSAPSSPDFEDLNDEDEGALDGEP 296
            ....:|...||                      |..|:|.||....:|
  Fly   273 AEEFNEPRRRLRAQSQLQSPLRLRFQPRHHHPHQHHQQRRRRYIGDAP----------------- 320

  Fly   297 QVAESRTRSR-RQAPYIIYPEVLVIVDYDGYRLHGGDNL------QVKRYFISFWNGVDLRY-RL 353
                   ||| ...|..::.|..:.||.|.| .|...|.      :|..:.::..|||.|.| ..
  Fly   321 -------RSRWSDIPEELFIETAIFVDSDLY-AHMQKNFPTNTESKVVSFLLAMINGVQLLYHHP 377

  Fly   354 LKGPRIRISIAGIIISRGRDATPYLERNRVGRDAIDSAAALTDMGKYL-----FRERRLPV---- 409
            ..|.||...:..:.|.:..| .|.|.|:|             |:..||     ::|:..|.
  Fly   378 TLGRRINFVLKRLEIWKSWD-PPGLVRSR-------------DVENYLNSFCKWQEKLNPFSDAD 428

  Fly   410 ---YDIAVAITKLDMCRRTSAYGECNRGTAGFAYVGGACVVNKRLEKVNSVAIIEDTGGFSGIIV 471
               ||.|:.:|.||:.  |...|:.|....|.|.|.|.|.      .:.| ..|.:...|..:.|
  Fly   429 PLHYDHALVLTGLDLV--TYDKGKANSQVVGMATVKGMCT------SIYS-CTINEAKHFESVFV 484

  Fly   472 AAHEVGHLLGAVHDGS----PPPSYLGGPGAQRCRWEDGYIMSDLRHTERGFRWSACTVQSFHHF 532
            .|||:||.||..||..    .|..::..|     :...|.:           .||.|:......|
  Fly   485 VAHEIGHNLGMRHDAKEISCDPTMHIMSP-----KLGSGKV-----------TWSKCSRTYLEDF 533

  Fly   533 LNGDTATCLHN-----APHEDSALGRSLPGTLLSLDAQCRRDRG---TYACFKDE-RVCAQLFCF 588
            |....|.||.:     .|.:.:|.|| |||...:.:.||....|   ..|..:.: .:|..|.|
  Fly   534 LMDPQAECLFDRDSFAGPWDHTAGGR-LPGERFNANQQCMLRFGKNFMQASTQSKMEICRDLHC- 596

  Fly   589 DAQTGYCVAYRPAAEGSACGNGYHCLDGRC-------------TPLPSNIIPDYGHNYRLV---- 636
             .|.|......||.||:.||....|..|.|             ...|...||:..|. :::
  Fly   597 -RQDGLPWTSHPALEGTECGPNMWCRGGTCEARSSKQGSYSALKSWPPEHIPEATHE-KIIRHEP 659

  Fly   637 ---------YNKIDNKKDAAEDVESSSEETESQEDETESVEDQD----EGTTSSEEQEDNKIEQS 688
                     ||.:||:...:.  .:..|.:|....|:..:..|.    ||:|.......:.:...
  Fly   660 NRIPPLLHDYNPMDNELPGSP--SNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRSCLNFP 722

  Fly   689 SAAGGAAAQ----STTTARSTTTTTVRTTSTTTTTAKPKSKSFGYLHRSLPERQWMQDNGVLVTT 749
            |...|...:    :|.........|:...:|.......||.         ||   :...|..:.:
  Fly   723 SRCIGRDRRFVTCNTPQCHKVPVQTINDFATQVCMQARKSD---------PE---LTGEGQQLPS 775

  Fly   750 RISSSVSSSSSGSSSGEAAATSTRR---PTTTTTTQTPNLFQIYTHELRKQIEYYLHMLQTQQHA 811
            .:.:|........::|    |.:||   |..||                         .:.:||
  Fly   776 TLDASCKIFCRTRTNG----TKSRRWTFPDGTT-------------------------CKAKQH- 810

  Fly   812 TKFQPEQQQQQSQQQQSIVEIPLVQKSLTNYSVT------SSSSSTSNGAKQ----------QPP 860
               .||.                     ..|.::      |..:||||..|.          :|.
  Fly   811 ---NPED---------------------ITYCISGRCERFSCDNSTSNFFKMDSSFCEARSVRPT 851

  Fly   861 SNKDENQRQQQQQQQAQQQLQDGLPDE---ENEAT------AGIQSNEAIERQKRKFPTTPTAAT 916
            .:..:.:.:||..:|...:.|:|.|.:   |||..      .|...|......||:
  Fly   852 RDSSDQESRQQTNRQRYAERQEGKPQKNHYENEVAKRPSYGQGNHINAPASPYKRR--------- 907

  Fly   917 SAAQKSATPATPATSATSARPTPTTAKPITTSSFLDAYFKKLQALHDAGSASS---------STT 972
             ...|...|..|       ||.|    |.:.|         |.||..:.|:.|         |..
  Fly   908 -NYHKPYPPEIP-------RPPP----PASAS---------LIALDRSSSSESEWVAHPGCHSNC 951

  Fly   973 TTTTTSVSSSVSSATSSKQQHPQQQQQQQVQQIADGSHFLKRTPHRSSLKAYKTSSSSSNNSSS 1036
            .|.:..|....|..|..:.......:.|..:::...:.:.::|..|...|....|...:..|:|
  Fly   952 MTDSKGVQGVTSRLTGVESIQLCSYRIQPCERLQTAAEYAEQTCARYRQKVRGLSGHGAQISAS 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	64/251 (25%)
stl	NP_001097423.1	Pep_M12B_propep	<155..239	CDD:279848	24/138 (17%)
		ZnMc_ADAMTS_like	331..543	CDD:239801	64/251 (25%)
		Reprolysin	332..545	CDD:279729	65/252 (26%)
		TSP1	683..741	CDD:214559	10/57 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6268
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13723
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.860