DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sona and Adamts18

DIOPT Version :9

Sequence 1:	NP_001137746.1	Gene:	sona / 37762	FlyBaseID:	FBgn0034903	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	XP_038953789.1	Gene:	Adamts18 / 361412	RGDID:	1560118	Length:	1253	Species:	Rattus norvegicus

Alignment Length:	705	Identity:	177/705 - (25%)
Similarity:	255/705 - (36%)	Gaps:	225/705 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GLPDLHKQMTPEQLQSVFHVDTHDAVPHYELVQLQHHENNHNRRRRSIGKGPKVNAALPPHHVKK 85
            ||.|.:..:.|.::.|.....:||.:              |||:|||
  Rat    91 GLNDDYVFVVPVEVDSGGSYISHDIL--------------HNRKRRS------------------ 123

  Fly    86 DLSKNAYYSELKHEALASGGNHLFAPEVSAIKSHNVSFSAFGQHLNLSLRAT---------QGLF 141
                            |.|          |..|.:..||||||.|:|.|:.:         |.|.
  Rat   124 ----------------AHG----------ASSSVHYRFSAFGQDLHLELKPSALLSSHFIVQVLG 162

  Fly   142 KGAPHQLRMWTVGSEPNATHGLDLQEIVHEQHTSNDVGEVFQDEKNMAAILMRRHMETGDLIMEG 206
            |....:.|      ||..     :|:.:::....||         :::::.:........||.
  Rat   163 KDGASETR------EPAV-----VQQCLYQGFIRND---------SLSSVAVSTCAGLSGLIR-- 205

  Fly   207 SIGHDLVIKPLPHELSPN-----PEESH-HIIYKREASAAEGQLSDFAFME-------PDDLLAS 258
            :..::.:|.|||..|:..     |...| |::|||.|.....:..|:...:       |.....:
  Rat   206 TRDNEFLISPLPQLLAQQHNYSLPAGHHPHVLYKRTAEKRVRRYQDYPASQRTYPGHSPSHTPPA 270

  Fly   259 EKLERLQRRQRR--------SRRSAPSSPDFEDLN---DEDEGALDGEPQVAESRTRSRRQAPYI 312
            .:.:..:.|.||        .|:.....|..||..   ||..||  |.|:      ||.|::...
  Rat   271 SQSQETEYRHRRWQKQHFCGRRKKYAPKPPAEDAYLRFDEYGGA--GRPR------RSARKSQKG 327

  Fly   313 IYPEVLVIVDYDGYRLHGGDNLQVKRYFISFWNGVDLRYRLLK----GPRIRISIAGIIISRGRD 373
            :..|.||:.|......||.|:  |..|.::..|.|.   .|.|    |..|.|.:..:|:.  .|
  Rat   328 LNVETLVVADAKMVEKHGKDD--VTTYILTVMNMVS---SLFKDGTIGSDINIVVVSLILL--ED 385

  Fly   374 ATPYLERNRVGRDAIDS-----AAALTDMGKYLFRERRLPVYDIAVAITKLDMCRRTSAYGECNR 433
            ....|..|.....:::|     :|.:...||.         :|.|:.:|..|:|...:.  .|:
  Rat   386 EPGGLLINHHADQSLNSFCQWQSALVGKNGKR---------HDHAILLTGFDICSWKNE--PCD- 438

  Fly   434 GTAGFAYVGGACVVNKRLEKVNSVAIIEDTG-GFSGIIVAAHEVGHLLGAVHDGSPPPSYLGGPG 497
             |.|||.:.|.|      .|..|..|.|||| |.:..|  |||.||..|.||||.      |.|
  Rat   439 -TLGFAPISGMC------SKYRSCTINEDTGLGLAFTI--AHESGHNFGMVHDGE------GNP- 487

  Fly   498 AQRCRWEDGYIMSDLRHTERG-FRWSACTVQSFHHFLNGDTATCLHNAPHEDSALGR-----SLP 556
               ||..:|.|||.......| |.||:|:.|....||:...|.||.:.|.:   .|:     .||
  Rat   488 ---CRKAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQ---TGQYKYPDKLP 546

  Fly   557 GTLLSLDAQCRRDRGTYA--C----FKDERVCAQLFCFDAQTGY-C-VAYRPAAEGSACGNGYHC 613
            |.:...|.||:...|..|  |    .||  :|..|:|.  :.|: | ..:.|||||:.||....|
  Rat   547 GQIYDADTQCKWQFGAKAKLCSLGVMKD--ICKSLWCH--RVGHRCETKFMPAAEGTVCGLSMWC 607

  Fly   614 LDGRCT------PLP-----------------------------SNIIPDYGHNY 633
            ..|:|.      |.|                             ||..|.||..|
  Rat   608 RQGQCVRLGDLGPRPIHGQWSAWSKWSECSRTCGGGVKYQERHCSNPKPQYGGKY 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	73/239 (31%)
Adamts18	XP_038953789.1	Pep_M12B_propep	99..238	CDD:396235	42/218 (19%)
		ZnMc_ADAMTS_like	328..529	CDD:239801	72/238 (30%)
		ADAM_CR_2	546..613	CDD:407643	24/70 (34%)
		TSP1	627..679	CDD:214559	6/36 (17%)
		ADAM_spacer1	784..896	CDD:368694
		TSP1_ADAMTS	918..966	CDD:408800
		TSP1_ADAMTS	970..1026	CDD:408800
		TSP1_ADAMTS	1030..1083	CDD:408800
		TSP1_ADAMTS	1091..1150	CDD:408800
		TSP1_ADAMTS	1159..1205	CDD:408800
		PLAC	1220..1250	CDD:400844
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810