DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sona and Adamts19

DIOPT Version :9

Sequence 1:	NP_001137746.1	Gene:	sona / 37762	FlyBaseID:	FBgn0034903	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	NP_001101903.2	Gene:	Adamts19 / 361332	RGDID:	1308359	Length:	1211	Species:	Rattus norvegicus

Alignment Length:	426	Identity:	104/426 - (24%)
Similarity:	168/426 - (39%)	Gaps:	80/426 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 DFAFMEP--DDLLASEKLERLQRRQRRS-----RRSAPSSPDFEDLNDEDEGALDGEP---QVAE 300
            ||.|:||  |.:.......||.|::|.|     .:||........::|:      |.|   ::||
  Rat   256 DFIFIEPFNDTMAIIGHPHRLYRQKRSSEERVTEKSAAHRHHCGVISDK------GRPRSKKLAE 314

  Fly   301 SRTRSR--RQAPYIIYPEVLVIVDYDGYRLHGGDNLQVKRYFISFWNGVDLRYRLLK----GPRI 359
            :|...|  .:.|.....|.:|:.|......||.|  ..:|:.::..|.|   :.|.:    |.::
  Rat   315 NRREKRYSYKLPQDYNIETVVVADPAMVSYHGAD--AARRFILTILNMV---FNLFQHKSLGVQV 374

  Fly   360 RISIAGIIISRGRDATPYLERNRVGRDAIDSAAALTDMGKYLFRE--RRLPVY------------ 410
            .:.:..:|:.....|..|:..:  |...::|..      |:...|  |:..::
  Rat   375 NLRVIKLILLHETPADLYIGHH--GEKMLESFC------KWQHEEFGRKNDIHLEMSTSWGEDVA 431

  Fly   411 --DIAVAITKLDMCRRTSAYGECNRGTAGFAYVGGACVVNKRLEKVNSVAIIEDTGGFSGIIVAA 473
              |.|:.||:.|.|.....  .|:  |.|.||:.|.|...::       .||.:..|.:.....|
  Rat   432 SVDAAILITRKDFCVHKDE--PCD--TVGIAYLNGMCSEKRK-------CIIAEDNGLNLAFTIA 485

  Fly   474 HEVGHLLGAVHDGSPPPSYLGGPGAQRCRWEDGYIMSDLRHTERGFRWSACTVQSFHHFLNGDTA 538
            ||:||.:|..|| :..||...|.......|..|..:.|:       .||.|:.:....||....:
  Rat   486 HEMGHNMGINHD-NDHPSCADGLHIMSGEWIKGQNLGDV-------SWSRCSKEDLERFLRSKAS 542

  Fly   539 TC-LHNAPHEDSA--LGRSLPGTLLSLDAQCRRDRGTYACFKDER---VCAQLFC-FDAQTGYCV 596
            :| ||..|...|:  :...|||...:.|.||:...|..|.|..|.   :|..|:| .:..|....
  Rat   543 SCLLHTDPQSLSSVLVPSKLPGMAYTADEQCQILFGPLASFCQEMQHVICTGLWCRVEGDTECRT 607

  Fly   597 AYRPAAEGSACGNGYHCLDGRC---TPLPSNIIPDY 629
            ...|..:|:.|..|..|..|.|   ||.|.::..::
  Rat   608 KLDPPMDGTDCDPGKWCKAGECTRRTPAPEHLAGEW 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	55/249 (22%)
Adamts19	NP_001101903.2	Pep_M12B_propep	162..277	CDD:396235	7/20 (35%)
		ZnMc_ADAMTS_like	329..546	CDD:239801	55/248 (22%)
		ADAM_CR_2	563..630	CDD:407643	19/66 (29%)
		ADAM_spacer1	794..904	CDD:368694
		TSP1_ADAMTS	928..980	CDD:408800
		TSP1_ADAMTS	984..1040	CDD:408800
		TSP1_ADAMTS	1044..1086	CDD:408800
		TSP1_ADAMTS	1095..1147	CDD:408800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810