DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sona and Adamts8

DIOPT Version :9

Sequence 1:	NP_001137746.1	Gene:	sona / 37762	FlyBaseID:	FBgn0034903	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	NP_038934.2	Gene:	Adamts8 / 30806	MGIID:	1353468	Length:	905	Species:	Mus musculus

Alignment Length:	686	Identity:	164/686 - (23%)
Similarity:	246/686 - (35%)	Gaps:	187/686 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 SAFGQHLNLSLRATQGLFKGAPHQLRMW-----TVGSEPNATHGLDLQEIVHEQHTSNDVGEVFQ 183
            |||||...|.| |....|.....::...     ..|.|| ...|....            |.|..
Mouse    60 SAFGQGFVLRL-APDASFLAPEFKIERLGGSSAAAGGEP-GLRGCFFS------------GTVNG 110

  Fly   184 DEKNMAAILMRRHMETGDLIMEGSIGHDLVIKP--------LPHELSP-NPEESHHIIYKRE--- 236
            :.:::||:.:.|.: :|..::   .|.:..|:|        .||.|.. .|.:      :||
Mouse   111 ERESLAAMSLCRGL-SGSFLL---AGEEFTIQPQGAGDSLDQPHRLQRWGPGQ------RREDPG 165

  Fly   237 ASAAEGQLSDFAFMEPDDLLASEKLERLQRRQRRSRRSAPSSPDFEDLNDEDEGAL----DGE-- 295
            .:|||      .|..|..|....::...|.::|        |.:.||...:.||.|    |..
Mouse   166 LAAAE------VFPLPQGLEWEVEMGNGQGQER--------SDNEEDRKQDKEGLLKETEDSRKV 216

  Fly   296 PQVAESRTRSRRQAPYIIYPEVLVIVDYDGYRLHGGDNLQVKRYFISFWNGVDLRYRLLKGPRIR 360
            |....|:|||:|......:.|.|::.|......:|.|   ::.:.::.   :.:..|:.|.|.||
Mouse   217 PPPFGSKTRSKRFVSEARFVETLLVADASMAAFYGTD---LQNHILTV---MSMAARIYKHPSIR 275

  Fly   361 ISIAGIIISRGRDATPYLERNRVGRDAIDSAA-ALTDMGKYLFR-----ERRLPVYDIAVAITKL 419
            .|:..:::.     ...:|....|.:..|:.. .|.:...:..|     :|....||.|:..|:.
Mouse   276 NSVNLVVVK-----VLIVEEEGWGPEVSDNGGLTLRNFCSWQRRFNKPSDRHPEHYDTAILFTRQ 335

  Fly   420 DMCRRTSAYGE-CNRGTAGFAYVGGACVVNKRLEKVNSVAIIEDTGGFSGIIVAAHEVGHLLGAV 483
            :.|.:    || |:  |.|.|.||..|..:|      |.::|:|. |.......|||:||:|...
Mouse   336 NFCGK----GEQCD--TLGMADVGTICDPDK------SCSVIKDE-GLQAAYTLAHELGHVLSMP 387

  Fly   484 HDGSPPPSYLGGPGAQRCRWEDGYIMSDLRHTERGFRWSACTVQSFHHFLNGDTATCLHNAPHED 548
            ||.|.|...|.||..:.......:|     |..:...||.|:.......|:.....||.:||...
Mouse   388 HDDSKPCVRLFGPMGKYHMMAPFFI-----HVNKTLPWSPCSAVYLTELLDDGHGDCLLDAPTSV 447

  Fly   549 SALGRSLPG--TLLSLDAQCRRDRGTYACFKD------ERVCAQLFC--FDAQTGYCVAYRPA-- 601
            ..|...|||  ||..||.||::..|  ..|:.      |.:|.||:|  .|:....|.....:
Mouse   448 LPLPTGLPGHSTLYELDQQCKQIFG--PDFRHCPNTSVEDICVQLWCRHRDSDEPICHTKNGSLL 510

  Fly   602 -AEGSACGNGYHCLDGRCTPLPSNIIPDYGHNYRLVYNKIDNKKDAAEDVESSSEETESQEDETE 665
             |:|:.||.|:.||||.|.                          ..||||:           .:
Mouse   511 WADGTPCGPGHLCLDGSCV--------------------------LKEDVEN-----------PK 538

  Fly   666 SVEDQD---------------EGTTSSEEQEDNKIEQSSAAGGAAAQSTTTARSTTTTTVRTTST 715
            :|.|.|               .|...|..:.||.:.|:   ||         |......|:..|.
Mouse   539 AVVDGDWGPWRPWGQCSRTCGGGIQFSNRECDNPMPQN---GG---------RFCLGERVKYQSC 591

  Fly   716 TTTTAKPKSKSF---------GYLHRSLPER--QWM 740
            .|....|..|||         .|.|..|...  ||:
Mouse   592 NTEECPPNGKSFREQQCEKYNAYNHTDLDGNFLQWV 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	56/235 (24%)
Adamts8	NP_038934.2	Pep_M12B_propep	52..152	CDD:279848	24/109 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..163		6/29 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..225		11/46 (24%)
		Reprolysin	234..444	CDD:279729	57/238 (24%)
		ZnMc_ADAMTS_like	234..441	CDD:239801	56/235 (24%)
		ADAM_CR	463..529	CDD:301627	22/67 (33%)
		TSP1	545..597	CDD:214559	11/63 (17%)
		Spacer	706..847
		ADAM_spacer1	706..825	CDD:283607
		TSP1	852..904	CDD:214559
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	877..905
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810