DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sona and Adamts5

DIOPT Version :9

Sequence 1:	NP_001137746.1	Gene:	sona / 37762	FlyBaseID:	FBgn0034903	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	NP_942056.2	Gene:	Adamts5 / 304135	RGDID:	735196	Length:	927	Species:	Rattus norvegicus

Alignment Length:	664	Identity:	148/664 - (22%)
Similarity:	232/664 - (34%)	Gaps:	172/664 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLFTALLLVSSTICQGL--------PDLHKQMTPEQLQSVFHVDTHDAVPHYELVQLQHHENNHN 62
            :|...|||.:|  |..|        |...|...|....:....|..    .:|..|.:.|.....
  Rat     8 LLLLLLLLCAS--CLALAADNPAAAPAQDKTRQPRAAAAAAQPDQR----QWEETQERGHPQPLA 66

  Fly    63 RRRRSIG----------KGPKVNAAL--PPHHVKKDLSKNAYYSELKHEALASGGNHLFAPEVSA 115
            |:|||.|          .|.||...:  .......||.::        :.:.:.|..:.|..:||
  Rat    67 RQRRSSGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERD--------DTVGAAGGIVTAGGLSA 123

  Fly   116 IKSHNVSFSAFGQHLNLSLRATQGLFKGAPHQLRMWTVGSEPNATHGLD-LQEIVHEQHTSNDVG 179
            ...|.       .|.     ..:|...|:|..|.::      :...||| ...:.|.::|
  Rat   124 SSGHR-------GHC-----FYRGTVDGSPRSLAVF------DLCGGLDGFFAVKHARYT----- 165

  Fly   180 EVFQDEKNMAAILMRRHMETGDLIMEGSIGHDLVIKPLPHELSPNPEESHHI----------IYK 234
                                              :|||   |..:..||..:          :|.
  Rat   166 ----------------------------------LKPL---LRGSWAESERVYGDGSSRILHVYT 193

  Fly   235 REASAAEGQLSDFAFMEPDDLLASEKLERLQRRQRRSRRSAPSSPDFEDLNDEDEGALDGEPQV- 298
            ||..:.|......:...|.....:::...:....||....||...|....:.    |.:..||.
  Rat   194 REGFSFEALPPRTSCETPASPSGAQESPSVHSSSRRRTELAPQLLDHSAFSP----AGNAGPQTW 254

  Fly   299 AESRTRSRRQAPYIIYPEVLVIVDYDGYRLHGGDNLQVKRYFISFWNGVDLRYRLLKGP----RI 359
            ...|.||..:|..:   |:|::.|....:::|..   ::.|.::.   ..:..||....    .|
  Rat   255 WRRRRRSISRARQV---ELLLVADSSMAKMYGRG---LQHYLLTL---ASIANRLYSHASIENHI 310

  Fly   360 RISIAGIIISRGRDATPYLERNRVGRDAIDSAAALTDMGKYLFRERRL-----PVYDIAVAITKL 419
            |:::..:::...:.    ||.::      ::|..|.:..|:..:..:|     ..||.|:..|:.
  Rat   311 RLAVVKVVVLTDKS----LEVSK------NAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTRE 365

  Fly   420 DMCRRTSAYGECNRGTAGFAYVGGACVVNKRLEKVNSVAIIEDTGGFSGIIVAAHEVGHLLGAVH 484
            |:|    .:..|:  |.|.|.||..|...:      |.|:|||.|..:...| |||:|||||..|
  Rat   366 DLC----GHHSCD--TLGMADVGTICSPER------SCAVIEDDGLHAAFTV-AHEIGHLLGLSH 417

  Fly   485 DGSPPPSYLGGPGAQRCR-----WEDGYIMSD-LRHTERGFRWSACTVQSFHHFLNGDTATCLHN 543
            |.|           :.|.     .||..:||. |...:....||.||..:...||:.....||.:
  Rat   418 DDS-----------KFCEENFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLD 471

  Fly   544 APHEDSALGRSLPGTLLSLDAQCRRDRG-TYACFKDERVCAQLFCFDAQTGYCVAYR---PAAEG 604
            .|.:.......|||.......||....| .|:......|||:|:|...:.|..|...   ||.||
  Rat   472 VPRKQILGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEG 536

  Fly   605 SACGNGYHCLDGRC 618
            :.||.|..||.|:|
  Rat   537 TPCGKGRICLQGKC 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	59/243 (24%)
Adamts5	NP_942056.2	Pep_M12B_propep	61..181	CDD:396235	32/187 (17%)
		ZnMc_ADAMTS_like	268..470	CDD:239801	59/244 (24%)
		ADAM_CR_2	484..551	CDD:407643	24/67 (36%)
		TSP1	567..619	CDD:214559
		ADAM_spacer1	729..849	CDD:368694
		TSP1_ADAMTS	876..927	CDD:408800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910