DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sona and Adamts16

DIOPT Version :9

Sequence 1:	NP_001137746.1	Gene:	sona / 37762	FlyBaseID:	FBgn0034903	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	NP_742050.2	Gene:	Adamts16 / 271127	MGIID:	2429637	Length:	1222	Species:	Mus musculus

Alignment Length:	663	Identity:	168/663 - (25%)
Similarity:	242/663 - (36%)	Gaps:	199/663 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LQSVFHVD------THDAVPHYELVQLQHHENNHNRRRRSIGK--GPKVNAAL--PPHHVKKDL- 87
            |.|.:.||      :|| :.||:          ..||||::.:  |..::..|  |.|.:..||
Mouse    58 LVSAYEVDHRGDYVSHD-IMHYQ----------RRRRRRAVTQPGGDALHLRLKGPRHDLHLDLK 111

  Fly    88 -SKNAYYSELKHEALASGGN---HLFAPEVSAIKSHNVSFSAFGQHLNLSLRATQGLFKGAPHQL 148
             :.|........:.|..||.   .:|.||.:..  :..|..:.| :.:::|...|||
Mouse   112 AASNLMAPGFMVQTLGKGGTKSVQMFPPEENCF--YQGSLRSQG-NSSVALSTCQGL-------- 165

  Fly   149 RMWTVGSEPNATHGLDLQEIVHEQHTSNDVGEVFQDEKNMAAILMRRHMETGDLIMEGSIGHDLV 213
                                                      :.|.|..:|           |..
Mouse   166 ------------------------------------------LGMIRTKDT-----------DYF 177

  Fly   214 IKPLPHEL------SPNPEESHHIIYKREASAAEGQLSDFAFMEPDDLLASEK------------ 260
            :||||..|      |...:...|::|||   :.|.|    |..|.:.|:.:.|
Mouse   178 LKPLPPHLTSKLNRSAQGDSPSHVLYKR---STERQ----APRENEVLMITRKRDLARPHLHHDN 235

  Fly   261 --LERLQRR----QRRSRRSAPSSPDFEDLNDEDEGALDGEPQVAESRTRSRRQAPYIIYPEVLV 319
              |...|::    :|:.....|.:.|...|.||      .:|.....|:..:......:..|.||
Mouse   236 FHLGPSQKQHFCGRRKKYMPQPPNDDLYILPDE------YKPSSRHKRSLLKSHRNEELNVETLV 294

  Fly   320 IVDYDGYRLHGGDNLQVKRYFISFWNGVDLRYRLLK----GPRIRISIAGIIISRGRDATPYLER 380
            :||....:.||.:|  :..|.::..|.|.   .|.|    |..|.|.|.|:|:         ||.
Mouse   295 VVDRKMMQSHGHEN--ITTYVLTILNMVS---ALFKDGTIGGNINIVIVGLIL---------LED 345

  Fly   381 NRVGRDAIDSAA--ALTD--------MGKYLFRERRLPVYDIAVAITKLDMCRRTSAYGECNRGT 435
            .:.|. ||...|  .||.        |||...|      :|.|:.:|.||:|...:.  .|:  |
Mouse   346 EQPGL-AISHHADHTLTSFCQWQSGLMGKDGTR------HDHAILLTGLDICSWKNE--PCD--T 399

  Fly   436 AGFAYVGGACVVNKRLEKVNSVAIIEDTG-GFSGIIVAAHEVGHLLGAVHDGSPPPSYLGGPGAQ 499
            .|||.:.|.|      .|..|..:.||:| |.:..|  |||.||..|.||||.          ..
Mouse   400 LGFAPISGMC------SKYRSCTVNEDSGLGLAFTI--AHESGHNFGMVHDGE----------GN 446

  Fly   500 RCRWEDGYIMSDLRHTERG-FRWSACTVQSFHHFLNGDTATCLHNAPH--EDSALGRSLPGTLLS 561
            .|:..:|.|||.......| |.||:|:.|..|.||:...|.||.:.|.  ::......|||.|..
Mouse   447 MCKKSEGNIMSPTLAGRNGVFSWSSCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGQLYD 511

  Fly   562 LDAQCRRDRGTYA--CFKDER--VCAQLFCFDAQTGYCVAYRPAAEGSACGNGYHCLDGRCTPL- 621
            .:.||:...|..|  |..|.|  :|..|:|..........:.|||||:.||....|..|:|...
Mouse   512 ANTQCKWQFGEKAKLCMLDFRKDICKALWCHRIGRKCETKFMPAAEGTLCGQDMWCRGGQCVKYG 576

  Fly   622 ---PSNIIPDYGH 631
               |.   |.:||
Mouse   577 DEGPK---PTHGH 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	77/244 (32%)
Adamts16	NP_742050.2	Pep_M12B_propep	88..187	CDD:279848	28/162 (17%)
		Cysteine switch. /evidence=ECO:0000250	245..253		1/7 (14%)
		ZnMc_ADAMTS_like	288..489	CDD:239801	76/243 (31%)
		Reprolysin	290..493	CDD:279729	78/245 (32%)
		TSP1	587..639	CDD:214559	168/663 (25%)
		Spacer	745..871
		ADAM_spacer1	745..856	CDD:283607
		TSP1	927..985	CDD:214559
		TSP1	988..>1017	CDD:214559
		TSP1	1056..1113	CDD:214559
		TSP1	1126..1179	CDD:214559
		PLAC	1188..1218	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810