DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sona and Adamts5

DIOPT Version :9

Sequence 1:	NP_001137746.1	Gene:	sona / 37762	FlyBaseID:	FBgn0034903	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	NP_035912.2	Gene:	Adamts5 / 23794	MGIID:	1346321	Length:	930	Species:	Mus musculus

Alignment Length:	407	Identity:	104/407 - (25%)
Similarity:	160/407 - (39%)	Gaps:	65/407 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 IYKREASAAEGQLSDFAFMEPDDLLASEKLERLQRRQRRSRRSAPSSPDFEDLNDEDEGALDGEP 296
            :|.||..:.|......:...|......::...:..|.||....||...|....:......    |
Mouse   192 VYNREGFSFEALPPRASCETPASPSGPQESPSVHSRSRRRSALAPQLLDHSAFSPSGNAG----P 252

  Fly   297 QV-AESRTRSRRQAPYIIYPEVLVIVDYDGYRLHGGDNLQVKRYFISFWNGVDLRYRLLKGP--- 357
            |. ...|.||..:|..:   |:|::.|....|::|..   ::.|.::.   ..:..||....
Mouse   253 QTWWRRRRRSISRARQV---ELLLVADSSMARMYGRG---LQHYLLTL---ASIANRLYSHASIE 308

  Fly   358 -RIRISIAGIIISRGRDATPYLERNRVGRDAIDSAAALTDMGKYLFRERRL-----PVYDIAVAI 416
             .||:::..:::...:|.:..:.:|        :|..|.:..|:..:..:|     ..||.|:..
Mouse   309 NHIRLAVVKVVVLTDKDTSLEVSKN--------AATTLKNFCKWQHQHNQLGDDHEEHYDAAILF 365

  Fly   417 TKLDMCRRTSAYGECNRGTAGFAYVGGACVVNKRLEKVNSVAIIEDTGGFSGIIVAAHEVGHLLG 481
            |:.|:|    .:..|:  |.|.|.||..|...:      |.|:|||.|..:...| |||:|||||
Mouse   366 TREDLC----GHHSCD--TLGMADVGTICSPER------SCAVIEDDGLHAAFTV-AHEIGHLLG 417

  Fly   482 AVHDGSPPPSYLGGPGAQRCR-----WEDGYIMSD-LRHTERGFRWSACTVQSFHHFLNGDTATC 540
            ..||.|           :.|.     .||..:||. |...:....||.||..:...||:.....|
Mouse   418 LSHDDS-----------KFCEENFGTTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNC 471

  Fly   541 LHNAPHEDSALGRSLPGTLLSLDAQCRRDRG-TYACFKDERVCAQLFCFDAQTGYCVAYR---PA 601
            |.:.|.:.......|||.......||....| .|:......|||:|:|...:.|..|...   ||
Mouse   472 LLDLPRKQILGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPA 536

  Fly   602 AEGSACGNGYHCLDGRC 618
            .||:.||.|..||.|:|
Mouse   537 VEGTPCGKGRVCLQGKC 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	60/243 (25%)
Adamts5	NP_035912.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..68
		Pep_M12B_propep	68..174	CDD:279848
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	207..231		3/23 (13%)
		Cysteine switch. /evidence=ECO:0000250	207..214		1/6 (17%)
		Reprolysin	269..476	CDD:279729	61/247 (25%)
		ZnMc_ADAMTS_like	269..473	CDD:239801	60/244 (25%)
		ADAM_CR	486..556	CDD:301627	25/68 (37%)
		TSP1	570..622	CDD:214559
		Spacer	732..874
		ADAM_spacer1	732..852	CDD:283607
		TSP1	879..930	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6268
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.760