DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sona and Adamts2

DIOPT Version :9

Sequence 1:	NP_001137746.1	Gene:	sona / 37762	FlyBaseID:	FBgn0034903	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	NP_783574.1	Gene:	Adamts2 / 216725	MGIID:	1347356	Length:	1213	Species:	Mus musculus

Alignment Length:	579	Identity:	149/579 - (25%)
Similarity:	215/579 - (37%)	Gaps:	149/579 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 SELKHEALASGGNHLFAPEVSAIKSHNVSFSAFGQHLNLSLRATQGLFKGAPHQLRMWTVGSEPN 158
            |.|...|....|..||           .:.:.||:.|:|.||....|.              .|.
Mouse    94 SGLPGGAAQDPGGRLF-----------YNLTVFGRDLHLRLRPNARLV--------------APG 133

  Fly   159 ATHGLDLQEIVHEQHTSND------------VGEVFQDEKNMAAILMRRHMETGDLIMEGSIGHD 211
            ||        |..|..:.|            ||:|....|..:..|.......|.:.||   ..:
Mouse   134 AT--------VEWQGETGDTRVEPLLGSCLYVGDVADLPKASSVALSNCDGLAGLIRME---EEE 187

  Fly   212 LVIKPLPHELSPNPEESH----HIIYKREASAAEGQLSDFAFMEPDDL---LASEKLERLQRRQR 269
            ..|:||  |.....:|:.    |::|:|..:.....:|     ||..|   ::...|:.|.|..
Mouse   188 FFIEPL--EKGQTDQEAEQGRVHVVYRRPPTPKPPPVS-----EPQALDTGVSQGNLDSLSRAL- 244

  Fly   270 RSRRSAPSSPDFEDLNDEDEGALDGEPQVAESRTRSRRQA---PYIIYPEVLVIVDYDGYRLHGG 331
                                |.|  |.::..||.|.||.|   .|.|  |||:.||....:.||.
Mouse   245 --------------------GVL--EERINSSRRRVRRHATDDDYNI--EVLLGVDDSVVQFHGK 285

  Fly   332 DNLQVKRYFISFWNGV-DLRYRLLKGPRIRISIAGII-ISRGRD------ATPYLERNRVGRDAI 388
            :::|  :|.::..|.| ::.:....|..|.:.:..|| :|..:.      ..|......|.|.|.
Mouse   286 EHVQ--KYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSHAKSMSLIEIGNPSQSLENVCRWAY 348

  Fly   389 DSAAALTDMGKYLFRERRLPVYDIAVAITKLDMCRRTSAYGECNRGTAGFAYVGGACVVNKRLEK 453
            ......||..:|         :|.|:.:|:.|       :|.  .|..|:|.|.|.|      ..
Mouse   349 LQQKPDTDHDEY---------HDHAIFLTRQD-------FGP--SGMQGYAPVTGMC------HP 389

  Fly   454 VNSVAIIEDTGGFSGIIVAAHEVGHLLGAVHDGSPPPSYLGGPGAQRCRWED--GYIMSDL-RHT 515
            |.|..:..: .|||...|.|||.||:||..|||.          ..||..|.  |.||:.| :..
Mouse   390 VRSCTLNHE-DGFSSAFVVAHETGHVLGMEHDGQ----------GNRCGDEVRLGSIMAPLVQAA 443

  Fly   516 ERGFRWSACTVQSFHHFLNGDTATCLHNAP--HEDSALGRSLPGTLLSLDAQCRRDRG----TYA 574
            ...|.||.|:.|....:|:  :..||.:.|  |:..||.: |||...|::.|||.|.|    ...
Mouse   444 FHRFHWSRCSQQELSRYLH--SYDCLRDDPFAHDWPALPQ-LPGLHYSMNEQCRFDFGLGYMMCT 505

  Fly   575 CFKDERVCAQLFCFDAQTGY-CVAYR-PAAEGSACGNGYHCLDGRCTPLPSNIIPDYGH 631
            .|:....|.||:|......| |...: |..:|:.|..|.||..|.|..|..:|:...|:
Mouse   506 AFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKHCFKGHCIWLTPDILKRDGN 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	65/239 (27%)
Adamts2	NP_783574.1	Pep_M12B_propep	99..210	CDD:279848	31/148 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..232		6/25 (24%)
		ZnMc_ADAMTS_like	267..468	CDD:239801	66/241 (27%)
		Reprolysin	269..471	CDD:279729	66/242 (27%)
		TSP1	565..617	CDD:214559	149/579 (26%)
		Cell attachment site. /evidence=ECO:0000255	692..694
		Spacer	723..851
		ADAM_spacer1	724..838	CDD:283607
		TSP1	864..915	CDD:214559
		TSP1	918..977	CDD:214559
		TSP1	983..1030	CDD:214559
		PLAC	1064..1094	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900