DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sona and ADAMTS18

DIOPT Version :9

Sequence 1:	NP_001137746.1	Gene:	sona / 37762	FlyBaseID:	FBgn0034903	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	NP_955387.1	Gene:	ADAMTS18 / 170692	HGNCID:	17110	Length:	1221	Species:	Homo sapiens

Alignment Length:	671	Identity:	169/671 - (25%)
Similarity:	255/671 - (38%)	Gaps:	200/671 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ALLLVSSTICQGLPDLHKQMTPEQLQSVFHVDTHDAVPHYELVQLQHHENNHNRRRRSIGKGPKV 74
            ||...||:...||.|.:..:||.::.|.....:||.:              ||.|
Human    45 ALASDSSSGASGLNDDYVFVTPVEVDSAGSYISHDIL--------------HNGR---------- 85

  Fly    75 NAALPPHHVKKDLSKNAYYSELKHEALASGGNHLFAPEVSAIKSHNVSFSAFGQHLNLSLRATQG 139
                     ||..::||.                        .|.:..||||||.|:|.|:.:..
Human    86 ---------KKRSAQNAR------------------------SSLHYRFSAFGQELHLELKPSAI 117

  Fly   140 LFKGAPHQLRMWTVGSE-PNATHGLDLQEIVHEQHTSNDVGEVFQDEKNMAAI--------LMRR 195
            |   :.|.: :..:|.: .:.|...::|:..::       |.:..|..:..|:        |:|.
Human   118 L---SSHFI-VQVLGKDGASETQKPEVQQCFYQ-------GFIRNDSSSSVAVSTCAGLSGLIRT 171

  Fly   196 HMETGDLIMEGSIGHDLVIKPLPHELS-----PNPEESH-HIIYKREAS-------AAEGQLSDF 247
            ..            ::.:|.|||..|:     .:|...| |::|||.|.       ...|...::
Human   172 RK------------NEFLISPLPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNY 224

  Fly   248 AFMEPDDL-LASEKLE------RLQRRQ--RRSRRSAPSSPDFEDLNDEDEGALDGEPQVAESRT 303
            ....|..: .||:..|      |||::.  .|.::.||..|..:.....||....|.|:
Human   225 PGYSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPR------ 283

  Fly   304 RSRRQAPYIIYPEVLVIVDYDGYRLHGGDNLQVKRYFISFWNGVDLRYRLLK----GPRIRISIA 364
            ||..::...:..|.||:.|......||..|  |..|.::..|.|.   .|.|    |..|.:.:.
Human   284 RSAGKSQKGLNVETLVVADKKMVEKHGKGN--VTTYILTVMNMVS---GLFKDGTIGSDINVVVV 343

  Fly   365 GIIISRGRDATPYLER-------NRVGRDAIDS-----AAALTDMGKYLFRERRLPVYDIAVAIT 417
            .:|:         ||:       |.....:::|     :|.:...||.         :|.|:.:|
Human   344 SLIL---------LEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKR---------HDHAILLT 390

  Fly   418 KLDMCRRTSAYGECNRGTAGFAYVGGACVVNKRLEKVNSVAIIEDTG-GFSGIIVAAHEVGHLLG 481
            ..|:|...:.  .|:  |.|||.:.|.|      .|..|..|.|||| |.:..|  |||.||..|
Human   391 GFDICSWKNE--PCD--TLGFAPISGMC------SKYRSCTINEDTGLGLAFTI--AHESGHNFG 443

  Fly   482 AVHDGSPPPSYLGGPGAQRCRWEDGYIMSDLRHTERG-FRWSACTVQSFHHFLNGDTATCLHNAP 545
            .:|||.      |.|    ||..:|.|||.......| |.||:|:.|....||:...|.||.:.|
Human   444 MIHDGE------GNP----CRKAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEP 498

  Fly   546 HEDSALGR-----SLPGTLLSLDAQCRRDRGTYA--C----FKDERVCAQLFCFDAQTGY-C-VA 597
            .:   .|:     .|||.:...|.||:...|..|  |    .||  :|..|:|.  :.|: | ..
Human   499 KQ---AGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKD--ICKSLWCH--RVGHRCETK 556

  Fly   598 YRPAAEGSACGNGYHCLDGRC 618
            :.|||||:.||....|..|:|
Human   557 FMPAAEGTVCGLSMWCRQGQC 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	71/246 (29%)
ADAMTS18	NP_955387.1	Pep_M12B_propep	86..202	CDD:279848	32/162 (20%)
		Cysteine switch. /evidence=ECO:0000250	252..259		1/6 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..291		9/38 (24%)
		ZnMc_ADAMTS_like	293..494	CDD:239801	70/245 (29%)
		Reprolysin	295..498	CDD:279729	72/247 (29%)
		TSP1	592..643	CDD:214559
		ADAM_spacer1	749..861	CDD:283607
		Spacer	750..876
		TSP1	938..992	CDD:214559
		TSP1	995..1049	CDD:214559
		TSP1	1059..1116	CDD:214559
		TSP1	1131..1178	CDD:214559
		PLAC	1188..1218	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810