Protein Alignment sona and ADAMTS17

DIOPT Version :10

• Sequence 1: NP_001137746.1
• Gene: sona / 37762
• FlyBaseID: FBgn0034903
• Length: 1102
• Species: Drosophila melanogaster
• Sequence 2: XP_016877462.1
• Gene: ADAMTS17 / 170691
• HGNCID: 17109
• Length: 1189
• Species: Homo sapiens
• Alignment Length: 767
• Identity: 156/767 - (20%)
• Similarity: 234/767 - (30%)
• Gaps: 287/767 - (37%)

  Fly     4 PLVLFTALLLV-----SSTICQGLPD----LHKQMTPEQLQSVFHVDTHDAVPHYELVQLQHHEN 59
            ||||...||||     .:.:.....|    |..::.|:.:    |:....|.|
Human     9 PLVLPVLLLLVWGLDPGTAVGDAAADVEVVLPWRVRPDDV----HLPPLPAAP------------ 57

  Fly    60 NHNRRRRSIGKGPKVNAALPPHHVKKDLSKNAYYSELKHEALASGGNHLFAPEVSAIKSHNVSFS 124
            ...||||     |:...|.|...                            |...|:..|   ..
Human    58 GPRRRRR-----PRTPPAAPRAR----------------------------PGERALLLH---LP 86

  Fly   125 AFGQHLNLSLRATQGLFKGAPHQLRMWTVGSEPNATHGLDLQEIVHEQHTSNDVGEVFQDEKNMA 189
            |||:.|.|.||          ..||.        .:.|.:::|....:.........|...:.:.
Human    87 AFGRDLYLQLR----------RDLRF--------LSRGFEVEEAGAARRRGRPAELCFYSGRVLG 133

  Fly   190 AILMRRHMETGDLIMEGSIG-------------HDLVIKPLPHELSPNPEESHHIIYK---REAS 238
                    ..|.|:...:.|             ..::|:||.:...|.....|.|..|   ..:.
Human   134 --------HPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQGPFSGREHLIRRKWSLTPSP 190

  Fly   239 AAEGQLSDFAFMEPDDL--LASEKLERLQRRQRRSRRSAPSSPDFEDLNDEDEGALDGEPQVAES 301
            :||.|       .|:.|  :.:||.:....|..|..|                          |.
Human   191 SAEAQ-------RPEQLCKVLTEKKKPTWGRPSRDWR--------------------------ER 222

  Fly   302 RTRSRRQAPYIIYPEVLVIVDYDGYRLHGGDNLQVKRYFISFWNGVDLRYRLLK----GPRIRIS 362
            |...|..:.:.:  |.||:.|.|..:.||.:..|  |:.::..|.|   |.:.:    |.:|.|.
Human   223 RNAIRLTSEHTV--ETLVVADADMVQYHGAEAAQ--RFILTVMNMV---YNMFQHQSLGIKINIQ 280

  Fly   363 IAGIIISRGRDA-------------------------TPYLERNRV--GRDAIDSAAALTDMGKY 400
            :..:::.|.|.|                         ..||..|:|  |:|  |.
Human   281 VTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKD--DP---------- 333

  Fly   401 LFRERRLPVYDIAVAITKLDMC----------------------------------------RRT 425
                   |:.|.||.:|:.|.|                                        :|.
Human   334 -------PLVDAAVFVTRTDFCVHKDEPCDTVVPPAPFDVREGPGSPPWWCLGRELPEANGSQRV 391

  Fly   426 SAYGECNRGTAGFAYVGGACVVNKRLEKVNSVAIIEDTGGFSGIIVAAHEVGHLLGAVHDGSPPP 490
            ......::...|.||:||.|...::       .::.:..|.:.....|||:||.||..|| ....
Human   392 IPDHSISKTWEGIAYLGGVCSAKRK-------CVLAEDNGLNLAFTIAHELGHNLGMNHD-DDHS 448

  Fly   491 SYLGGPGAQRCRWEDGYIMSDLRHTERGFRWSACTVQSFHHFLNGDTATCL--------HNA--P 545
            |..|........|..|...|||       .||:|:.....:||....:|||        |..  |
Human   449 SCAGRSHIMSGEWVKGRNPSDL-------SWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLP 506

  Fly   546 HEDSALGRSLPGTLLSLDAQCRRDRGTYACF---KDERVCAQLFCF-DAQTGYCVAYRPAAEGSA 606
            |:       |||...|.:.||:...|..|.|   .:..:||.|:|. :..|.......|..:|:.
Human   507 HK-------LPGMHYSANEQCQILFGMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTE 564

  Fly   607 CGNGYHCLDGRC---TPLPSNIIPDY-------------GHNYRLVYNKIDN 642
            ||....|..|.|   ||:|.::..|:             |...|....|.||
Human   565 CGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDN 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	64/307 (21%)
		ADAMTS_CR_2	556..619	CDD:465496	20/69 (29%)
ADAMTS17	XP_016877462.1	Pep_M12B_propep	<81..180	CDD:460254	21/127 (17%)
		ZnMc_ADAMTS_like	232..493	CDD:239801	63/301 (21%)
		ADAMTS_CR_2	510..577	CDD:465496	19/66 (29%)
		TSP1	590..642	CDD:214559	5/27 (19%)
		ADAMTS_CR_3	<674..743	CDD:437068
		ADAMTS_spacer1	781..877	CDD:461796
		TSP1_ADAMTS	903..955	CDD:465950
		TSP1_ADAMTS	959..1015	CDD:465950
		TSP1_ADAMTS	1019..1061	CDD:465950
		TSP1_ADAMTS	1070..1117	CDD:465950