DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sona and ADAMTS6

DIOPT Version :9

Sequence 1:	NP_001137746.1	Gene:	sona / 37762	FlyBaseID:	FBgn0034903	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	NP_922932.2	Gene:	ADAMTS6 / 11174	HGNCID:	222	Length:	1117	Species:	Homo sapiens

Alignment Length:	642	Identity:	156/642 - (24%)
Similarity:	234/642 - (36%)	Gaps:	145/642 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 SVFHVDTHDAVPHYE--LVQLQHHE--------------------NNHNRRRRSIGKGPKVNAAL 78
            |.||.|...:....|  |..|:|::                    :.|:|||||          :
Human    19 SEFHSDHRLSYSSQEEFLTYLEHYQLTIPIRVDQNGAFLSFTVKNDKHSRRRRS----------M 73

  Fly    79 PPHHVKKDLSKNAYYSELKHEALASGGNHLFAPEVSAIKSHNVSFSAFGQ--HLNLSLRATQGLF 141
            .|...::.:||                  ||           ...||:|:  ||||:|...   |
Human    74 DPIDPQQAVSK------------------LF-----------FKLSAYGKHFHLNLTLNTD---F 106

  Fly   142 KGAPHQLRMWTVGSEPNATHGLDLQEIVHEQHTSNDVGEVFQDEKNMAAILMRRHMETGDLIMEG 206
            ......:..|          |.|..:..|:...:.......||:::...:.:...:....:|  .
Human   107 VSKHFTVEYW----------GKDGPQWKHDFLDNCHYTGYLQDQRSTTKVALSNCVGLHGVI--A 159

  Fly   207 SIGHDLVIKPLPHELSPNP----EESH-HIIYKREASAAEGQLSDFAFMEPDDLLASEKLERLQR 266
            :...:..|:||.:....:.    |..| |:|||:.| ..:..|.|.:.....|...|.|
Human   160 TEDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKKSA-LQQRHLYDHSHCGVSDFTRSGK------ 217

  Fly   267 RQRRSRRSAPSSPDFEDLNDEDEGALDGEPQVAESRTRSRRQAPYIIYPEVLVIVDYDGYRLHGG 331
                        |.:  |||....:............|.:|......:.|.||:.|......||
Human   218 ------------PWW--LNDTSTVSYSLPINNTHIHHRQKRSVSIERFVETLVVADKMMVGYHG- 267

  Fly   332 DNLQVKRYFISFWNGVDLRYR-LLKGPRIRISIAGIIISRGRDATPYLERNRVGRDAIDS----- 390
             ...::.|.:|..|.|...|| ...|..:.|.:|.:|:.  .:..|.||.|.....::||
Human   268 -RKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVL--TEDQPNLEINHHADKSLDSFCKWQ 329

  Fly   391 AAALTDMGK-YLFRERRLPVYDIAVAITKLDMCRRTSAYGECNRGTAGFAYVGGACVVNKRLEKV 454
            .:.|:.... ....|..:..:|.||.||:.|:|    .|.....||.|.|.|.|.|      |..
Human   330 KSILSHQSDGNTIPENGIAHHDNAVLITRYDIC----TYKNKPCGTLGLASVAGMC------EPE 384

  Fly   455 NSVAIIEDTGGFSGIIVAAHEVGHLLGAVHDGSPPPSYLGGPGAQRCRWEDGYIMSDLRHTERGF 519
            .|.:|.||.|..|...: |||:||..|..|||.  .:..|..|.:..:....:|.::    ...|
Human   385 RSCSINEDIGLGSAFTI-AHEIGHNFGMNHDGI--GNSCGTKGHEAAKLMAAHITAN----TNPF 442

  Fly   520 RWSACTVQSFHHFLNGDTATCLHNAPHEDSALGRSL-PGTLLSLDAQCRRDRGTYA--CFKDERV 581
            .||||:......||:....|||.|.|.:...|..:: ||.:...|.|||...|..:  | |...|
Human   443 SWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRFQYGATSRQC-KYGEV 506

  Fly   582 CAQLFCFDAQTGYCVAYR-PAAEGSACGNGY----HCLDGRCTPL---PSNIIPDYG 630
            |.:|:|. :::..||... |||||:.|..|.    .|..|.|.|.   |.:|...:|
Human   507 CRELWCL-SKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTWPQSIDGGWG 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	67/235 (29%)
ADAMTS6	NP_922932.2	Pep_M12B_propep	69..190	CDD:279848	31/174 (18%)
		Reprolysin	250..468	CDD:279729	69/238 (29%)
		ZnMc_ADAMTS_like	250..465	CDD:239801	67/235 (29%)
		TSP1	561..613	CDD:214559	1/2 (50%)
		Spacer	717..843
		ADAM_spacer1	719..829	CDD:283607
		TSP1	848..900	CDD:214559
		TSP1	902..960	CDD:214559
		TSP1	1022..1069	CDD:214559
		PLAC	1083..1115	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810