Protein Alignment sona and ADAMTS5

DIOPT Version :9

• Sequence 1: NP_001137746.1
• Gene: sona / 37762
• FlyBaseID: FBgn0034903
• Length: 1102
• Species: Drosophila melanogaster
• Sequence 2: NP_008969.2
• Gene: ADAMTS5 / 11096
• HGNCID: 221
• Length: 930
• Species: Homo sapiens
• Alignment Length: 519
• Identity: 127/519 - (24%)
• Similarity: 189/519 - (36%)
• Gaps: 136/519 - (26%)

  Fly   138 QGLFKGAPHQLRMWTVGSEPNATHGLD-LQEIVHEQHT----------SNDVGEVFQDEKNMAAI 191
            :|...|:|..|.::      :...||| ...:.|.::|          ..:.|.|:.|  ..|.|
Human   133 RGTVDGSPRSLAVF------DLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGD--GSARI 189

  Fly   192 LMRRHMETGDLIMEGSIGHDLVIKPLPHELS-----PNPEESHHIIYKREAS---AAEGQLSDFA 248
            |   |:.|    .||     ...:.||...|     ..||...|.......|   |...||.|.:
Human   190 L---HVYT----REG-----FSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQS 242

  Fly   249 FMEPDDLLASEKLERLQRRQRRSRRSAPSSPDFEDLNDEDEGALDGEPQVAESRTRSRRQAPYII 313
            .:.|   ......:...||:|||                            .||.|.
Human   243 ALSP---AGGSGPQTWWRRRRRS----------------------------ISRARQ-------- 268

  Fly   314 YPEVLVIVDYDGYRLHGGDNLQVKRYFISFWNGVDLRYRLLKGP----RIRISIAGIIISRGRDA 374
             .|:|::.|....||:|..   ::.|.::.   ..:..||....    .||:::..:::...:|.
Human   269 -VELLLVADASMARLYGRG---LQHYLLTL---ASIANRLYSHASIENHIRLAVVKVVVLGDKDK 326

  Fly   375 TPYLERNRVGRDAIDSAAALTDMGKYLFRERRL-----PVYDIAVAITKLDMCRRTSAYGECNRG 434
            :..:.:|        :|..|.:..|:..:..:|     ..||.|:..|:.|:|    .:..|:
Human   327 SLEVSKN--------AATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLC----GHHSCD-- 377

  Fly   435 TAGFAYVGGACVVNKRLEKVNSVAIIEDTGGFSGIIVAAHEVGHLLGAVHDGSPPPSYLGGPGAQ 499
            |.|.|.||..|...:      |.|:|||.|..:...| |||:|||||..||.|           :
Human   378 TLGMADVGTICSPER------SCAVIEDDGLHAAFTV-AHEIGHLLGLSHDDS-----------K 424

  Fly   500 RCR-----WEDGYIMSD-LRHTERGFRWSACTVQSFHHFLNGDTATCLHNAPHEDSALGRSLPGT 558
            .|.     .||..:||. |...:....||.||..:...||:.....||.:.|.:.......|||.
Human   425 FCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEELPGQ 489

  Fly   559 LLSLDAQCRRDRG-TYACFKDERVCAQLFCFDAQTGYCVAYR---PAAEGSACGNGYHCLDGRC 618
            ......||....| .|:......|||:|:|...:.|..|...   ||.||:.||.|..||.|:|
Human   490 TYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKC 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	61/243 (25%)
ADAMTS5	NP_008969.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..69
		Pep_M12B_propep	67..168	CDD:307618	9/40 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..231		5/24 (21%)
		Cysteine switch. /evidence=ECO:0000250	207..214		1/6 (17%)
		ZnMc_ADAMTS_like	269..473	CDD:239801	61/241 (25%)
		TSP1	570..622	CDD:214559
		Spacer	732..874
		ADAM_spacer1	732..852	CDD:310520
		TSP1	879..930	CDD:214559

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6268
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.760