Protein Alignment sona and ADAMTS8

DIOPT Version :9

• Sequence 1: NP_001137746.1
• Gene: sona / 37762
• FlyBaseID: FBgn0034903
• Length: 1102
• Species: Drosophila melanogaster
• Sequence 2: NP_008968.4
• Gene: ADAMTS8 / 11095
• HGNCID: 224
• Length: 889
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 140/564 - (24%)
• Similarity: 223/564 - (39%)
• Gaps: 126/564 - (22%)

  Fly   102 ASGG--NHLFAP-----EVSAIKSHNVSFSAFGQHLNLSLRATQGLFKGAPHQLRMWTVGSEPNA 159
            |:||  :.|..|     ....:..|   .||||:...|.|.......  || :.::..:|....|
Human    32 AAGGQASELVVPTRLPGSAGELALH---LSAFGKGFVLRLAPDDSFL--AP-EFKIERLGGSGRA 90

  Fly   160 THG-LDLQEIVHEQHTSNDVGEVFQDEKNMAAILMRRHMETGDLIMEGSIGHDLVIKP------- 216
            |.| ..|:.....       |.|..:.:::||:.:.|.: :|..:::   |.:..|:|
Human    91 TGGERGLRGCFFS-------GTVNGEPESLAAVSLCRGL-SGSFLLD---GEEFTIQPQGAGGSL 144

  Fly   217 -LPHELS--------PNPEESHHIIYKREASAAEGQLSDFAFMEPDDLLASEKLERLQRRQRRSR 272
             .||.|.        |.|...     :.|....|||                       ||.|..
Human   145 AQPHRLQRWGPAGARPLPRGP-----EWEVETGEGQ-----------------------RQERGD 181

  Fly   273 RSAPSSPDFEDLNDEDEGALDGEPQVAESRTRSRRQAPYIIYPEVLVIVDYDGYRLHGGDNLQVK 337
            ....|..:.::  :|.|||.:..|.:. :.:|::|......:.|.|::.|......:|.|   ::
Human   182 HQEDSEEESQE--EEAEGASEPPPPLG-ATSRTKRFVSEARFVETLLVADASMAAFYGAD---LQ 240

  Fly   338 RYFISFWNGVDLRYRLLKGPRIRISIAGIIISRGRDATPYLERNRVGRDAIDSAA-ALTDMGKYL 401
            .:.::.   :.:..|:.|.|.|:.||..:::.     ...:|..:.|.:..|:.. .|.:...:.
Human   241 NHILTL---MSVAARIYKHPSIKNSINLMVVK-----VLIVEDEKWGPEVSDNGGLTLRNFCNWQ 297

  Fly   402 FR-----ERRLPVYDIAVAITKLDMCRRTSAYGECNRGTAGFAYVGGACVVNKRLEKVNSVAIIE 461
            .|     :|....||.|:.:|:.:.|.:.   |.|:  |.|.|.:|..|..||      |.::||
Human   298 RRFNQPSDRHPEHYDTAILLTRQNFCGQE---GLCD--TLGVADIGTICDPNK------SCSVIE 351

  Fly   462 DTGGFSGIIVAAHEVGHLLGAVHDGSPPPSYLGGPGAQRCRWEDGYIMSDL-RHTERGFRWSACT 525
            |. |.......|||:||:|...||.|.|.:.|.||..:.      ::|:.| .|..:...||.|:
Human   352 DE-GLQAAHTLAHELGHVLSMPHDDSKPCTRLFGPMGKH------HVMAPLFVHLNQTLPWSPCS 409

  Fly   526 VQSFHHFLNGDTATCLHNAPHEDSALGRSLPG--TLLSLDAQCRRDRG--------TYACFKDER 580
            .......|:|....||.:||.....|...|||  .|..||.|||:..|        |.|    :.
Human   410 AMYLTELLDGGHGDCLLDAPAAALPLPTGLPGRMALYQLDQQCRQIFGPDFRHCPNTSA----QD 470

  Fly   581 VCAQLFCF-DAQTGYCVAYR---PAAEGSACGNGYHCLDGRCTP 620
            |||||:|. |.....|....   |.|:|:.||.|:.|.:|.|.|
Human   471 VCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLP 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	58/235 (25%)
ADAMTS8	NP_008968.4	Pep_M12B_propep	50..150	CDD:279848	25/116 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	138..210		18/102 (18%)
		Reprolysin	219..429	CDD:279729	59/238 (25%)
		ZnMc_ADAMTS_like	219..426	CDD:239801	58/235 (25%)
		ADAM_CR	448..514	CDD:301627	25/69 (36%)
		TSP1	529..581	CDD:214559
		Spacer	690..831
		ADAM_spacer1	690..809	CDD:283607
		TSP1	836..888	CDD:214559

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810