DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sona and adamts17

DIOPT Version :9

Sequence 1:	NP_001137746.1	Gene:	sona / 37762	FlyBaseID:	FBgn0034903	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	XP_021333385.1	Gene:	adamts17 / 101884120	ZFINID:	ZDB-GENE-121030-7	Length:	1134	Species:	Danio rerio

Alignment Length:	461	Identity:	115/461 - (24%)
Similarity:	169/461 - (36%)	Gaps:	103/461 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 AEGQLSDFAFMEPDDLLASEKLERLQRRQRRSRRSAPSSPDFEDLNDEDEGALDGEPQVAES--- 301
            ||.:|    |:||.. .|::.....:.|..|.:.|:|..|         ..|.||..|..:|
Zfish   147 AEERL----FIEPVG-QAADSFSGWEHRVIREKHSSPDGP---------APAADGREQFCQSIHD 197

  Fly   302 -----------RTRSRRQA-----PYIIYPEVLVIVDYDGYRLHGGDNLQVKRYFISFWNGVDLR 350
                       :.|.||.|     .|.:  |.||:.|.:..:.||.:..|  |:.::..|.|
Zfish   198 KKKEKRPRGAEQVRGRRNAIRLSREYTV--ETLVVADANMVQYHGAEAAQ--RFLLTVMNMV--- 255

  Fly   351 YRLLK----GPRIRISIAGIIISRGRDATPYLERNRVGRDAIDSAAALTDMGKYLFRERRL---- 407
            |.:.:    |.|:.|.:..:::...|.     |:.:||.....:..:........:..|.|
Zfish   256 YNMFQHQSLGLRLNIRVTKLVLLHNRP-----EKLKVGHHGEKALESFCHWQHEEYGARYLGNNH 315

  Fly   408 --------PVYDIAVAITKLDMCRRTSAYGECNRGTAGFAYVGGACVVNKRLEKVNSVAIIEDTG 464
                    |..|.||.:|:.|.|.....  .|:  |.|.||:||.|...::       .::.:..
Zfish   316 VPGSRDDPPPVDAAVLVTRTDFCVHKDE--PCD--TVGIAYLGGTCSSKRK-------CVLAEDN 369

  Fly   465 GFSGIIVAAHEVGHLLGAVHDGSPPPSYLGGPGAQRCRWEDGYIMSDLRHTERGFRWSACTVQSF 529
            |.:.....|||:||.:|..|| ....|..|........|..|...|||       .||.|:....
Zfish   370 GLNLAFTIAHELGHNMGMSHD-DDHASCTGHSHIMSGEWVKGRNPSDL-------SWSTCSRDDL 426

  Fly   530 HHFLNGDTATC-LHNAPHED--SALGRSLPGTLLSLDAQCRRDRGTYACF---KDERVCAQLFCF 588
            ..||....:.| ||..|...  ..|...|||...|.|.||:...||.|.|   .:..:||.|:|.
Zfish   427 EKFLRSKASGCLLHTDPRNRYLVRLPAKLPGMHYSADEQCQILFGTNATFCTDMEHLMCAGLWCL 491

  Fly   589 -DAQTGYCVAYRPAAEGSACGNGYHCLDGRC---TPLPSNIIPDY-------------GHNYRLV 636
             :..|.......|..:|:.||....|..|.|   ||:|.::..|:             |...|..
Zfish   492 VEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPQHVDGDWSPWSTWSMCSRTCGTGARFR 556

  Fly   637 YNKIDN 642
            ..|.||
Zfish   557 QRKCDN 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	57/245 (23%)
adamts17	XP_021333385.1	Pep_M12B_propep	33..170	CDD:307618	7/27 (26%)
		ZnMc_ADAMTS_like	223..439	CDD:239801	58/246 (24%)
		TSP1	536..587	CDD:214559	5/27 (19%)
		ADAM_spacer1	729..824	CDD:310520
		TSP1	907..>931	CDD:214559
		TSP1	966..1013	CDD:214559
		TSP1	1018..1070	CDD:214559
		PLAC	1099..1123	CDD:312271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810