Protein Alignment sona and adam28

DIOPT Version :10

• Sequence 1: NP_001137746.1
• Gene: sona / 37762
• FlyBaseID: FBgn0034903
• Length: 1102
• Species: Drosophila melanogaster
• Sequence 2: NP_001233133.1
• Gene: adam28 / 100488450
• XenbaseID: XB-GENE-982024
• Length: 780
• Species: Xenopus tropicalis
• Alignment Length: 1037
• Identity: 195/1037 - (18%)
• Similarity: 318/1037 - (30%)
• Gaps: 359/1037 - (34%)

  Fly     1 MSSPLVLFTALLLVSSTICQGLPDLHKQMTPEQLQSVFHVDTHDAVPHYELVQLQHHENNHNRRR 65
            |..||:|.||.||:..      |...:::|         :|     |:||:|   ..:..|.:.:
 Frog     1 MLLPLLLLTAGLLLPQ------PAASQKLT---------ID-----PYYEVV---FPKKIHAQHK 42

  Fly    66 RSIGKGPKVNAALPPHHVKKDLSKNAYYSELKHEALASGGNHLFAPEVSAIKSHNVSFSAFGQHL 130
            |.:                     ...|.|:....:..||.||.   :...|:.::        |
 Frog    43 RDV---------------------QGMYPEVVQYGIHMGGKHLI---LHLEKNEDL--------L 75

  Fly   131 NLSLRATQGLFKGAPHQLRMWTVGSEPNATHGLDLQEIVHEQHTSNDVGEVFQDEKNMAAIL--- 192
            :.:...|..|..|.|       |.:.|.      :|...:.|      |.|..|..::|:|.
 Frog    76 SANYTETYYLSDGTP-------VTTSPK------IQNHCYYQ------GNVKNDNGSLASISTCS 121

  Fly   193 -MRRHMETGDLIMEGSIGHDLVIKPLPHELSPNPEESHHIIYKREASAAEGQLSDFAFMEPDDLL 256
             :|..::|     ||.:   .:|:||     .:.:...|.:|       |.|:
 Frog   122 GLRGLIQT-----EGQM---YLIEPL-----KDTDSESHAVY-------EAQM------------ 154

  Fly   257 ASEKLERLQRRQRRSRRSAPSSPDFEDLNDEDEGALDGEPQVAESRTRSRRQAPYII----YPEV 317
                             ..|.:...::....:|..      |.:||:.|..:...|:    |..:
 Frog   155 -----------------ETPKTCGVDNTTYREEIV------VKKSRSGSSAEQQQILKAQKYIRL 196

  Fly   318 LVIVDYDGYRLHGGDNLQVKRYFISFWNGVDLRYRLLKGPRIRISIAGIIISRGRDATPYLERNR 382
            :|:.|...:..:......||.......|.|::.|:.:   ...:::.||.:....|      :.:
 Frog   197 VVVADNSMFIKYNKSITNVKIRIFEVINFVNVVYKAI---NTFVALIGIEVWNTTD------QFK 252

  Fly   383 VGRDAIDSAAALTDMGKYLFRERRLPVYDIAVAITKLDMCRRTSAYGECNRGTAGFAYVGGACVV 447
            |...|....||..|..|.:.. ||.| .|.|..:|..|.          :..|.|.||||..|
 Frog   253 VVTSASADLAAFADWRKNVLL-RRTP-NDNAQLLTNTDF----------DGATVGLAYVGTEC-- 303

  Fly   448 NKRLEKVNSVAIIEDTGGFS-GI-IVAAHEVGHLLGAVHDGSPPPSYLGGPGAQRCRWEDGYIMS 510
                .:.:|..:|:|....| |: ...|||:||.||..||......     .|..|      ||:
 Frog   304 ----SETHSAGVIQDHSKASIGVGATVAHELGHNLGMNHDTDSCSC-----SASSC------IMA 353

  Fly   511 DLRHTERGFRWSACTVQSFHHFLNGDTATCLHNAPHEDSALGRSLPG---TLLSLDAQCRR-DRG 571
            ..........:|:|::|::..||......|:...|.::..:..::.|   |.:..|..|.. :..
 Frog   354 PYLSVNTPRLFSSCSLQNYQDFLLSRMPQCMLAVPLKEDIIAPAVCGNKFTEIGEDCDCGTVEEC 418

  Fly   572 TYAC-------FKDERVCAQLFC-------------------------FDAQTGYCVAYRPAAEG 604
            |..|       .|....||:..|                         .|.::..|.:.|....|
 Frog   419 TNQCCDAATCKLKSTAKCAEGDCCDNCQIKKAGSVCRAAKDDCDLADMCDGKSSVCPSDRFRVNG 483

  Fly   605 SACGNGY-HCLDGRCTPLPSNIIPDYGHNYRLVYNKIDNKKDAAEDVESSSEETESQEDETESVE 668
            ..|.||. :|.:|:|....|.....:|                |..|.|        ||...:|.
 Frog   484 FPCSNGKGYCFNGKCPTHQSQCTTLWG----------------ASSVPS--------EDSCFNVN 524

  Fly   669 DQ--DEGTTSSEEQEDNKIEQSSAAGGAAAQSTTTARSTTTTTVRTTSTTTTTAKPKSKSFGYLH 731
            .:  |.|             ..:.||                      .|....|||....|.|.
 Frog   525 TRGVDYG-------------YCTMAG----------------------ATYVPCKPKDVKCGMLF 554

  Fly   732 --------------------RSLPERQWMQDNGVLVTTRISSSVSSSSSGSSSGEAAATSTRRPT 776
                                |::..:..|..||    |:....:...:...||.|:|..|
 Frog   555 CYGGSSQPSIYAAVAEFSRCRAVLAQGGMVQNG----TKCGDGMVCYNGACSSIESAYRS----- 610

  Fly   777 TTTTTQTPNLFQIYTHELRKQIEYYLHMLQTQQHATKFQPEQQQQQSQQQQSIVEIPLV------ 835
            |..:.|... ..:..||:..|.|            ..:.|......|.....|:.:.:|
 Frog   611 TNCSAQCSG-HAVCDHEMLCQCE------------EGWAPPTCDVASPTNIIIIVVVIVIALALV 662

  Fly   836 ---------------QKSLTNYSVT-SSSSSTSNGAKQQPPSNKDENQRQQQQQQQAQQQLQDGL 884
                           ::|.:::..| :...||:...:.|||                 .|:|..|
 Frog   663 IGLVFLARFYRGKGKKQSSSSFPATVTVEGSTNPSFRNQPP-----------------PQMQMPL 710

  Fly   885 PD--EENEATAGIQSNEAIERQKRKFPTTPTAATSAAQKSATPATPATSATSARPTPTTAKP 944
            |.  :...||........:..|..::..| ||:..|..|...|.........|:|.|..|.|
 Frog   711 PQVHKPKPATDKSWPPSRVGYQAPQYSVT-TASPQAEPKLKKPTVAPPPVPPAKPAPPPAPP 771

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	55/234 (24%)
		ADAMTS_CR_2	556..619	CDD:465496	19/99 (19%)
adam28	NP_001233133.1	Pep_M12B_propep	30..150	CDD:460254	33/186 (18%)
		ZnMc_adamalysin_II_like	192..385	CDD:239797	55/230 (24%)
		Disintegrin	405..477	CDD:459709	10/71 (14%)
		ACR	482..601	CDD:214743	30/181 (17%)