Protein Alignment sona and adamts12

DIOPT Version :10

• Sequence 1: NP_001137746.1
• Gene: sona / 37762
• FlyBaseID: FBgn0034903
• Length: 1102
• Species: Drosophila melanogaster
• Sequence 2: XP_017946319.2
• Gene: adamts12 / 100380018
• XenbaseID: XB-GENE-959575
• Length: 1569
• Species: Xenopus tropicalis
• Alignment Length: 1441
• Identity: 279/1441 - (19%)
• Similarity: 436/1441 - (30%)
• Gaps: 528/1441 - (36%)

  Fly     4 PLVLFTALLLVSSTICQGLPDLHKQMTPEQL-QSVFHVDTHDAVPHYELVQ-------------- 53
            ||:|         .||.| ..||:. .|..| :...|:| |.....:|:|:
 Frog    30 PLLL---------AICHG-TRLHRD-NPHSLHKGQEHLD-HSLPLAFEVVEPVKVDEKGNFLSYN 82

  Fly    54 LQHHENNHNRRRRSIGKGPKVNAALPPHHVKKDLSKNAYYSELKHEALASGGNHLFAPEVSAIKS 118
            |||      ||:||:                   :..|.:..:.|                  |:
 Frog    83 LQH------RRKRSV-------------------ASQAIHYRIHH------------------KT 104

  Fly   119 HNVSFSAFGQHLNLSLRATQGLF---------KGAPHQLRMWTVGSEPNATHGLDLQEIVHEQHT 174
            ||:.|       ||:.|  .|..         .|.....|:     .|...:|..|.......|.
 Frog   105 HNLFF-------NLTFR--DGFLSDNFILERRNGNSSHARI-----SPQLGNGCHLIGTAQRAHV 155

  Fly   175 SNDVGEVFQDEKNMAAILMRRHMETGDLIMEGSIGHDLVIKPLPHELSPNPEESHHIIYKREASA 239
            ...|..:  ...|..|...|  :..||..:|...|...| ...||:         ||||:|::
 Frog   156 GGGVAAI--SVCNGLAGFFR--LPDGDYFIEPFHGATQV-SGKPHQ---------HIIYQRDS-- 204

  Fly   240 AEGQLSDFAFMEPDDLLASEKLERLQRRQRRSRRSAP-SSPDFEDLNDEDEGALDGEPQVAE--- 300
                                        ..|:||..| |:.||..:||..:..|..|.|..|
 Frog   205 ----------------------------PHRNRRELPISTGDFCAVNDNSKSVLQQERQREEWER 241

  Fly   301 ----SRTRSRRQAPYIIYPEVLVIVDYDGYRLHGGDNLQVKRYFISFWNGV-DLRYRLLKGPRIR 360
                .|..|:|......:.|.||:.|......||.:|  |:.|..:..|.| .|.:....|..|.
 Frog   242 KHLNGRKISQRSVSKERWVETLVVADTKMIAYHGSNN--VESYIFTIMNMVTGLFHDPNIGNAIH 304

  Fly   361 ISIAGIIISRGRDATPYLERNRVGRDAIDSA-AALTDMGKYLFRERRL-------PV-YDIAVAI 416
            |.:..:|:         ||....|...:.:| ..|....|:   ::.:       |. :|:||.:
 Frog   305 IKVVRLIL---------LEEEEEGLKIVHNADQTLASFCKW---QKSINPKSDAHPAHHDVAVLL 357

  Fly   417 TKLDMCRRTSAYGECNRGTAGFAYVGGACVVNKRLEKVNSVAIIEDTG---GFSGIIVAAHEVGH 478
            |:.|:|  .|....|.  |.|.:::.|.|..:|      |..|.||||   .|:    .|||:||
 Frog   358 TRKDIC--ASKNSPCE--TLGLSHLSGMCQPSK------SCNINEDTGLPLAFT----IAHELGH 408

  Fly   479 LLGAVHDGSPPPSYLGGPGAQRCRWEDGYIMS-DLRHTERGFRWSACTVQSFHHFLNGDTATCLH 542
            ..|..|||......:.|        .:.|||| .|::......||.|:.:....||:.....||.
 Frog   409 SFGIQHDGQGNDCEIAG--------RNPYIMSRQLQYNTSPLTWSPCSKEYITRFLDRGWGFCLD 465

  Fly   543 NAP-HEDSALGRSLPGTLLSLDAQCRRDRGTYACFKDE--RVCAQLFCFDAQTGYCVAYRPAAEG 604
            :.| .:|.......||.|..::.||:...|..|.|.:|  .||..|:| ..:.........||:|
 Frog   466 DVPAKKDLKPPIIAPGVLYDVNHQCQLQYGPNATFCEEVDNVCQTLWC-SVKNSCRSKLDSAADG 529

  Fly   605 SACGNGYHCLDGRC-----------------TPLP-----------------SNIIPDYG----- 630
            :.||....|.:|:|                 ||..                 :|..|.:|
 Frog   530 TRCGESKWCFNGKCINVGTTPQTINGGWGAWTPWSHCSRTCGAGAENAERKCNNPQPKFGGKYCT 594

  Fly   631 ---HNYRL-----------------------------------VYN--------------KIDNK 643
               ..||:                                   :||              ...||
 Frog   595 GERKRYRICNIQPCPKDYPSFREMQCTEFNTVPYKNELYQWIPIYNTENPCELHCRSSSGNFANK 659

  Fly   644 -KDAAEDVESSSEETESQ---------------EDETESVEDQ-----DEGTTSS---------- 677
             .||..|.....|..:|:               |.::.:.||:     .:|::..
 Frog   660 FLDAVIDGTPCFERNKSRDVCINGICKKVGCDYEIDSNATEDRCGICLGDGSSCQTIKKVFNQTD 724

  Fly   678 -----------EEQEDNKIEQSSAAGG-AAAQSTTTAR------------------STTTTTVRT 712
                       :...|.|||:...||. .|.:|....:                  .|.....|.
 Frog   725 GFGYVDVGLIPKGARDIKIEEVEEAGNFLALRSEDPGKYYLNGAYIIQWNGEYKVAGTIFHYQRN 789

  Fly   713 TSTTTTTAK-PKSKSFGYLHRSLPERQWMQ------DNGVLVTTRISSSVSSSSS---------- 760
            ..|...||. |.::|.           |:|      :.||.....|...|:..:.
 Frog   790 NDTENITASGPTNESI-----------WIQLLFQEHNPGVRYEYVIQKDVNLENEIESVYTWRYG 843

  Fly   761 -----GSSSGEAAATSTRRPTTTTTTQTPNLF-----QIYTHELR---KQIEYYLHMLQTQQHAT 812
                 .::.|........|..........|.|     |..|.:.:   |:......:.|.||.:|
 Frog   844 GWTDCSATCGTGVQHQISRCVNKKRGVVKNTFCDQEMQPITRQKKCNTKECPPRWWVGQWQQCST 908

  Fly   813 KFQP----------------EQQQQQSQQQQSIVEIPLVQKS------------LTNYSVTS--- 846
            ...|                :::..:|:....:.: |.|..|            ::|:|..|
 Frog   909 TCGPTGEKKRTVLCLKTSGSDEEALRSEDCHHLTK-PKVYLSCNRDILCPSDWTVSNWSECSVTC 972

  Fly   847 -------------------SSSSTSN-----GAKQ--------QPP------------SNKDENQ 867
                               .||...|     |.:|        :||            .:.|..:
 Frog   973 GGGVRTRNITCAKNNDEPCDSSKKPNSKALCGLQQCYVQKTLPKPPIKYNYRKKIIKKKSGDPKR 1037

  Fly   868 RQQQQQQQAQQQLQDGLP------DEENEATAGIQS-------NE----------------AIER 903
            |.....:..:.|...|||      ...|.::..::|       ||                .:|.
 Frog  1038 RIFLPNKNHRVQTTTGLPRVFMSTSSTNSSSPSVKSIKEDFQINEIPNSTHFNIDYKYNFVLVEN 1102

  Fly   904 QKRKFPTTPTA---ATSAAQKSATPATPATSATSARPTP----TTAKPITTSSFLDAYFKKLQAL 961
            .|||.....|:   :.|...|.....| .|.:.:.:.:|    ||.:|...:|......::.|:.
 Frog  1103 NKRKVHVNATSISPSVSNRTKVGNMET-GTESIAEKDSPPIFTTTRRPEELTSKYQLLTEQPQSQ 1166

  Fly   962 HDAGSASSSTTTTT---TTSVSSSVSS-------ATSSKQQHPQQQQQQQVQQIADGSHFLKRTP 1016
            .::|:...||....   .|.::..:.|       .|:..|.|| .....|.:...:.|..:.:||
 Frog  1167 TESGNMRGSTVDPNGDYDTDINFIIESRSKRHKGKTNQNQNHP-GTNLNQTESPTNSSILINQTP 1230

  Fly  1017 HRSSLKAYKTSSSSSNNSSSQTQQQQQQQQQQYATNYIGDTTNNQPAVLDNSGSASSTTETAKKP 1081
                |..|.|.|.|:...:|....|..:.        :..|.:.||:.|..:.|.:....|.|..
 Frog  1231 ----LSTYNTVSISNTEGNSTRNNQDWRD--------VAPTASAQPSFLQVTTSNTPENSTWKVN 1283

  Fly  1082 KIKTQKLIRRT 1092
            ....:.|:..|
 Frog  1284 NASNRYLLNYT 1294

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	64/242 (26%)
		ADAMTS_CR_2	556..619	CDD:465496	21/81 (26%)
adamts12	XP_017946319.2	Pep_M12B_propep	65..200	CDD:460254	38/205 (19%)
		ZnMc_ADAMTS_like	258..465	CDD:239801	64/242 (26%)
		ADAMTS_CR_2	480..544	CDD:465496	20/64 (31%)
		TSP1	557..609	CDD:214559	7/51 (14%)
		ADAMTS_CR_3	615..713	CDD:437068	13/97 (13%)
		ADAMTS_spacer1	715..824	CDD:461796	19/119 (16%)
		TSP1_ADAMTS	840..894	CDD:465950	7/53 (13%)
		TSP1_ADAMTS	898..952	CDD:465950	9/54 (17%)
		TSP1_ADAMTS	960..1008	CDD:465950	7/47 (15%)
		TSP1_ADAMTS	1312..1360	CDD:465950
		TSP1_ADAMTS	1363..1418	CDD:465950
		TSP1_ADAMTS	1421..1467	CDD:465950
		TSP1_ADAMTS	1470..1525	CDD:465950